Sickle cell disease burden among tribal population of India: a narrative review
DOI:
https://doi.org/10.18203/2394-6040.ijcmph20243320Keywords:
Sickle cell disease, Tribal health, Prevalence, TribesAbstract
Sickle cell disease (SCD) is a serious health challenge for tribal communities in India. These groups often have limited access to healthcare, lack proper awareness of the disease, and face higher rates of illness and death due to SCD. This review looks at the impact of SCD on tribal populations and identifies the states where the burden is most significant. A review of existing literature was conducted using sources like PubMed and Google Scholar. The focus was on studies that explored the prevalence of SCD among tribal populations. Various government reports and research articles were also examined to create a well-rounded understanding of how SCD affects these communities. The findings show that Madhya Pradesh and Chhattisgarh have particularly high rates of SCD compared to other parts of India. In these states, between 10% and 30% of tribal groups carry the sickle cell trait. Other states, such as Odisha and Maharashtra, have lower rates of the disease, suggesting that specific attention is needed in regions like Madhya Pradesh and Chhattisgarh to manage the disease more effectively. SCD continues to pose a serious public health issue in India’s tribal regions, particularly in certain states. It is essential to develop strategies that focus on raising awareness, improving access to healthcare, and managing SCD effectively in these communities. Public health efforts must include community involvement, education programs, and policy changes to better address the unique challenges faced by these populations.
Metrics
References
World Health Organization. Sickle Cell Disease. Available at: https://www.afro.who.int/health-topics/ sickle-cell-disease. Accessed on 07 August 2024.
Johns Hopkins Medicine. Sickle Cell Disease. Available at: https://www.hopkinsmedicine.org/ health/conditions-and-diseases/sickle-cell-disease. Accessed on 07 August 2024.
Madegowda C, Rao CU. The Sickle Cell Anemia health problems Traditional and Modern treatment practices among the Soliga tribes at B. R. Hills, South India. Antrocom Online J Anthropol. 2013;9(2):243-51.
World Health Organization. Sickle cell anaemia. Agenda item 11.4. 59th World Health Assembly. 2006;27. Available at: https://apps.who.int/gb/ ebwha/pdf_files/wha59/a59_9-en.pdf. Accessed on 07 August 2024.
Thomson AM, McHugh TA, Oron AP, Teply C, Lonberg N, Vilchis Tella VM, et al. Global, regional, and national prevalence and mortality burden of sickle cell disease, 2000–2021: a systematic analysis from the Global Burden of Disease Study 2021. Lancet Haematol. 2023;10(8).
Rao P, Raj EA, Natesan S, Gudi N. Prevalence of Sickle cell disease, Sickle cell trait and HBS-beta-thalassemia in India: A systematic review and Meta-analysis. Clin Epidemiol Glob Health. 2024;28:101678.
Anthroencyclopedia. Tribes. Available at: https:// www.anthroencyclopedia.com/entry/tribe. Accessed on 07 August 2024.
Naheeda, Asif SM, Padma M, Paul A. Assessment of periodontal status of Konda Reddy tribe in Bhadrachalam, Khammam district, India. Journal of Clinical and Diagnostic Research. 2015;9(6):ZC23-5.
Tribal Health Report, India. Executive Summary. Available at: http://tribalhealthreport.in/executive-summary/. Accessed on 07 August 2024.
Colah RB, Mukherjee MB, Martin S, Ghosh K. Sickle cell disease in tribal populations in India. Indian J Med Res. 2015;141(5):509-15.
Ministry of Health and Family Welfare. Guidelines for national programme for prevention & management of sickle cell disease. 2023. Available at: https://sickle.nhm.gov.in/uploads/english/Operat ionalGuidelines.pdf. Accessed on 07 August 2024.
Rao VR. Genetics and epidemiology of sickle cell anemia in India. Indian J Med Sci. 1988;42(9).
NHSRC- Census Data. Demographic Status of Scheduled Tribe Population of India. 2011. Available at: https://nhsrcindia.org/sites/default/files/2021-05/ Demographic%20Status%20of%20Scheduled%20Tribe%20Population%20-%20NHSRC.pdf. Accessed on 07 August 2024.
Debnath A, Singh N, Gupta S, Kishore J. Burden of Tuberculosis among tribal populations of India: A systematic review and meta-analysis. Lung India. 2024;41(2):121-9.
Nair AS, Vidhya KM, Saranya TR, Sreelakshmy KR, Nair SC. Burden of Sickle Cell Diseases Among Tribes of India- a Burning Problem. Int Res J Pharm Appl Sci. 2013;3(1):60-80.
Yadav R, Lazarus M, Ghanghoria P, Singh MPSS, Gupta RB, Kumar S, et al. Sickle cell disease in Madhya Pradesh, Central India: A comparison of clinical profile of sickle cell homozygote vs. sickle-beta thalassaemia individuals. Hematology. 2016;21(9):558-63.
Gupta RB. Sickle Cell Disease in Central India - Need for Micro Level Planning. 2009. Available at: https://www.nirth.res.in/publications/nsth/15.RB.Gupta.pdf. Accessed on 07 August 2024.
Singh K, Patel KP, Singh RP, Khare AK. Study of Sickle Cell Anemia in High Incidence Tribal Area Belt in Madhya- Pradesh-Shahdol District. Neuroquantology. 2022;20(19):3974-80.
Urade BP, Bhattacharyya N, Roy CS, Das J. Haemoglobinopathies in Saharia: A particularly vulnerable tribal group of Shivpuri district of Madhya Pradesh. Indian J Appl Res. 2017;7(2):663-4.
Chakma T, Rao PV, Meshram PK, Singh SB. Health and Nutrition Profile of Tribals of Madhya Pradesh and Chhattisgarh. Proceeding of National Symposium on Tribal Health. 2006;197-209.
Debnath D. The health problems and status of the particularly vulnerable tribal groups of madhya pradesh - A case study in anthropological dimension. Man India. 2014;94(4).
Kumar R, Sahu B, Yadav R, Shanmugam R. P-043: Geographical and Ethnic Distribution of Sickle Cell Disease in Madhya Pradesh and Chhattisgarh States of India. Hemasphere. 2022;6:38-9.
Dawar A, Mujalde VS, Chopda AK, Khare AK, Ahirwar T. Study to-How Sickle Cell Anemia Affects, Tribal Area of Central India Population. J Popul Ther Clin Pharmacol. 2023;30(17):759-65.
Chourasia S, Kumar R, Singh MPSS, Vishwakarma C, Gupta AK, Shanmugam R. High Prevalence of Anemia and Inherited Hemoglobin Disorders in Tribal Populations of Madhya Pradesh State, India. Hemoglobin. 2020;44(6):391-6.
Singh MPSS, Gupta RB, Yadav R, Gadge VS, Das U, Godbole S, et al. Prevalence of Common Haemoglobinopathies among Scheduled Caste and Scheduled Tribes of Shahdol and Khandwa (East Nimar) Districts of Madhya Pradesh. Proceeding of National Symposium on Tribal Health. 2024;123-7.
Patra PK, Tripathi S, Khodiar P, Sablania P, Keshari JR, Dalla AR. Epidemiology of sickle cell disease in state of Chhattisgarh. Indian J Public Health Res Dev. 2010;1(2):64-8.
Lad H, Chandak G, Patra P. P-066: Burden and Distribution of Sickle Cell Anemia in Tribal and Non-Tribal Population of State Chhattisgarh, India. Hemasphere. 2022;16(6):48.
Patra PK, Chauhan VS, Khodiar PK, Dalla AR, Serjeant GR. Screening for the sickle cell gene in Chhattisgarh state, India: An approach to a major public health problem. J Community Genet. 2011;2(3):147-51.
Urade B. Sickle Cell Gene (HbS) Scenario in Tribal India. J Health Med Inform. 2012;03:3.
Warade J, Pandey A. Distribution of Sickle Cell Disease in Different Communities of Patient Visiting Out Patient Department. Int J Adv Res Biol Sci. 2014;1(6):226-31.
Kate SL, Lingojwar DP. Epidemiology of Sickle Cell Disorder in the State of Maharashtra. Int J Hum Genet. 2002;2(3):161-7.
Mahajan AR, Zade VS, Chede SM, Sreenath J. Magnitude of Sickle Cell Disease in Pardhan, Gond, Kolam, Madgi, Gowari and Banjara Individuals of Yavatmal District, Maharashtra, India. Int J Curr Res. 2015;7(2):12769-74.
Garg B, Garg N, Prajapati N, Bharambe M, Deshmukh P. Prevalence of sickle cell disorders in rural Wardha. Indian J Comm Med. 2006;31(1).
Ministry of Health and Family Welfare-Government of India. Guidelines for National Programme for Prevention & Management of Sickle Cell Disease. 2023. Available at: https://sickle.nhm.gov.in /uploads/english/OperationalGuidelines.pdf. Accessed on 07 August 2024.
Deore AU, Zade SB. Epidemiology of sickle cell disorder : The urban scenario in Maharashtra , India. Int J Public Health Epidemiol. 2013;2(5).
Saxena D, Yasobant S, Golechha M. Situational analysis of sickle cell disease in Gujarat, India. Indian J Comm Med. 2017;42(4):218-21.
Mistry S, Shah K, Patel J. Prevalence of sickle cell disease in tribal peoples of Valsad district region in Gujarat, India. Trop J Pathol Microbiol. 2018;4(1):109-12.
Vasava B, Chudasama R, Godara N, Srivastava R. Prevalence of sickle cell disease in tribal adolescents of the South Gujarat region, India. Int J Trop Med. 2012;6(1).
Gupte S, Patel A, Shah A, Sorathiya S. Hemoglobinopathies in South Gujarat population and incidence of anemia in them. Indian J Hum Genet. 2012;18(3):294.
Rupani MP, Vasava BC, Mallick KH, Gharat VV, Bansal R. Reaching community through school going children for sickle cell disease in Zankhvav Village of Surat District, Western India. Online J Health All Sci. 2012;11(2).
Sharma RS, Parckh JG, Shah KM. Hemoglobinopathies in Western India. J Assoc Physicians India. 1963;11:969-73.
Balgir RS. The spectrum of haemoglobin variants in two scheduled tribes of Sundargarh district in north-western Orissa, India. Ann Hum Biol. 2005;32(5):560-73.
Purohit P, Dehury S, Patel S, Patel DK. Prevalence of Deletional Alpha Thalassemia and Sickle Gene in a Tribal Dominated Malaria Endemic Area of Eastern India. ISRN Hematol. 2014;2014:745245.
Sahu T, Sahani NC, Das S, Sahu SK. Sickle Cell Anaemia in Tribal Children of Gajapati District in South Orissa. Indian J Comm Med. 2003;28(4):180-3.
Das A, Dixit S, Kumar Barik M, Ghosal J, Babu B, Bal M, et al. Knowledge and perception related to sickle cell disease among tribal community, India: A mixed-method study. J Natl Med Assoc. 2023;115(4):441-53.
Dunlop KJ, Mozumder UK. The occurrence of sickle cell anaemia among a group of tea garden labourers in Upper Assam. Ind Med Gaz. 1952;87(9):387-91.
Teli AB, Deori R, Saikia SP. Haemoglobinopathies and β-thalassaemia among the tribals working in the tea gardens of Assam, India. J Clin Diagn Res. 2016;10(12):LC19-22.
Pathak MS, Borah MS. Genetic Hemoglobin Disorders Among the People of Assam-A Tertiary Care Hospital Based Study. Int J Med Res Health Sci. 2023;12(1):65-70.
Shah A, Hussain R, Fareed M, Afzal M. Gene frequency of sickle cell trait among Muslim populations in a malarial belt of India, i.e., Manipur. Egypt J Med Human Genet. 2012;13(3):323-30.
Urade BP. Haemoglobinopathies – HbE and HbS among the Gallong Tribe of West Siang District of Arunachal Pradesh, India. Med Sci. 2014;7(26):83-9.
Mohanty SS, Purohit A, Anand PK, Huda RK, Sharma AK. Burden of sickle cell disease in tribal students in Maa-Baadi institutions in southern Rajasthan - A pilot study. Indian J Med Res. 2022;156(2):269-74.
Mandot S, Khurana VL, Sonesh JK. Sickle cell anemia in garasia tribals of Rajasthan. Indian Pediatr. 2009;46(3):239-40.
Nayudu NV. Field survey for sickle cell disease in the tribal population of East Godavari District, Andhra Pradesh. J Assoc Physicians India. 1990;38(7):479-81.
Babu BV, Leela BLK, Kusuma YS. Sickle cell disease among tribes of Andhra Pradesh and Orissa, India. Anthropol Anz. 2002;60(2):169-74.
Haritha P, Lakshmi V, Veerraju P, Sarkar BN, Rao VR. Prevalence of Hemoglobinopathies among the Konda Kammaras of Visakhapatnam District, Andhra Pradesh. IOSR J Pharm Biol Sci. 2012;2(4):6-8.
Haritha P, Lakshmi V, Veerraju P. Research of Sickle Cell Trait in Four Tribal Communities of Visakhapatnam District. Asian J Sci Technol. 2014;5(5).
Devi. Sickle cell trait among Bagatha and Porangi Porja tribes of Visakhapatnam district, Waltair. In: UGC National Seminar on Anthropological Perspectives of man and environment. 1986.
Elizabeth AM, Saraswathy KN, Sachdeva MP, Kalla AK. Incidence of Sickle Cell Haemoglobin among the Thotis of District Adilabad, Andhra Pradesh. The Anthropologist. 2001;3(3):201-5.
Babu MS, Veerraju P, Naidu JM. A note on the sickle cell trait in a tribal population on coastal Andhra Pradesh. Indian Anthropologist. 1980;10(2):125-9.
Feroz M, Aravindan KP. Sickle Cell Disease Among Tribals of Attappady. Integrated Rural Technology Centre, Palakkad. Supported by Kerala Research Programme on Local Level Development (KRPLLD). 2017.
Ajmera S, Banoth B, Ramkishan R, Rao R. Prevalence of Sickle Cell Anaemia and Thalassaemia in Tribal Lambada (Banjara) Community in Warangal District, Telangana, India. J Evol Med Dent Sci. 2017;6(36).
Feroze M, Aravindan KP. Sickle cell disease in Wayanad, Kerala: Gene frequencies and disease characteristics. Natl Med J India. 2001;14(5):267-70.
Kaur M, Das GP, Verma IC. Sickle cell trait and disease among tribal communities in Orissa, Madhya Pradesh and Kerala. Indian J Med Res. 1997;105:111-6.
Verma IC, Saxena R, Kohli S. Hemoglobinopathies in India-Clinical and Laboratory Aspects. Clin Lab Med. 2012;32(2):249-62.
Rao P, Raj EA, Natesan S, Gudi N. Prevalence of Sickle cell disease, Sickle cell trait and HBS-beta-thalassemia in India: A systematic review and Meta-analysis. Clin Epidemiol Glob Health. 2024;28:101678.
Narayanasamy K, Catherine M, Kalpana S, Sunder JS, Valarmathi S, Srinivas G. Sickle Cell Disease and Maternal Health in Tribal Populations: A Comprehensive Review. Int J Sci Res. 2024;13(10):1-3.
Aggarwal P, Bhat D. Genetic counseling in sickle cell disease: Insights from the Indian tribal population. J Community Genet. 2023;14(4):345-53.
Kumar MM, Pathak V, Ruikar M. Tribal population in India: A public health challenge and road to future. J Family Med Prim Care. 2020;9(2):508-12.
Babu BV, Sridevi P, Surti SB, Ranjit M, Bhat D, Sarmah J, et al. Improving the Capacity of Health System and Community for Sickle Cell Disease Screening and Management Among Tribal Population in India: Protocol of an Intervention Study. Curr Health Sci J. 2020;46(3):270-9.