Comparison of platelet to lymphocyte ratio and neutrophil to lymphocyte ratio in women with preterm premature rupture of membranes and women with preterm delivery

Authors

  • Mahsa Khodadost Department of Gynecology, School of Medicine, Ardabil University of Medical Science, Ardabil, Iran
  • Zahra Ghavami Department of Gynecology, School of Medicine, Ardabil University of Medical Science, Ardabil, Iran
  • Rogayeh Dargahi Department of Gynecology, School of Medicine, Ardabil University of Medical Science, Ardabil, Iran
  • Firouz Amani Department of Biostatistics and Community Medicine, School of Medicine, Ardabil University of Medical Science, Ardabil, Iran

DOI:

https://doi.org/10.18203/2394-6040.ijcmph20241816

Keywords:

Neutrophil to lymphocyte ratio, Preterm delivery, Preterm premature rupture of membranes

Abstract

Background: Considering the adverse effect of PROM on birth outcomes and the condition of mother and fetus, early identification of risk factors of PROM and their control can reduce the occurrence of adverse outcomes for mother and fetus and improve their health. This study was conducted with the aim of comparing PLR and NLR in women with PROM and women with preterm delivery.

Methods: This case-control study was conducted on 155 women with PPROM as case group and 155 women with preterm delivery as control group. Age, gestational age, type of delivery, baby's birth weight, gravida, parity, APGAR score, rate of hospitalization in Neonatal Intensive Care Unit (NICU), occurrence of neonatal sepsis and development of respiratory distress syndrome (RDS) were recorded from women's medical records. Also, the results of blood tests and PLR and NLR values were calculated for each pregnant woman. Collected data were analyzed by statistical methods in SPSS version 24.

Results: The average gestational age and weight of babies at birth time in the case group were significantly lower than those with preterm delivery. The mean of NLR in case group with 4.8±2.5 was significantly higher than control group with 4.2±2.2. The mean of PLR in case group with 111.5±47.6 was significantly higher than control group with 100.98±43.4.

Conclusions: The high values of PLR and NLR in the women with PROM compared to women with preterm delivery can be a marker to identify the risk of PPROM in pregnant women.

References

Zhang S, Zhang W, Luan X, Jin Z. Diagnostic value of neutrophil/ lymphocyte ratio and platelet/ lymphocyte ratio in premature rupture of membranes complicated by sepsis. J Coll Physicians Surg Pak. 2022;32(5):602-5.

Lakshmi MS, Sravani VL. Role of neutrophil-lymphocyte ratio in determining the outcomes of preterm premature rupture of membranes. Int J Reprod Contracept Obstetr Gynecol. 2021;10(4):1617-21.

Yuce E. Neutrophil-to-Lymphocyte Ratio (NLR) and Platelet-to-Lymphocyte Ratio (PLR) can predict spontaneous preterm birth? J Inflamm Res. 2023;16:2423-9.

Enjamo M, Deribew A, Semagn S, Mareg M. Determinants of Premature Rupture of Membrane (PROM) among pregnant women in southern ethiopia: a case-control study. Int J Womens Health. 2022;14:455-66.

Assefa NE, Berhe H, Girma F, Berhe K, Berhe YZ, Gebreheat G, et al. Correction to: Risk factors of premature rupture of membranes in public hospitals at Mekele city, Tigray, a case control study. BMC Pregnancy Childbirth. 2020;20(1):28.

Kalantarimoghaddam F, Karami Robati F. Evaluation of effective factors on the premature rupture of membranes in pregnant women referred to Afzalipour Hospital, Kerman. Tehran Univ Med J 2023;80(10):808-814.

Sae‐Lin P, Wanitpongpan P. Incidence and risk factors of preterm premature rupture of membranes in singleton pregnancies at Siriraj Hospital. J Obstetr Gynaecol Res. 2019;45(3):573-7.

Argaw M, Mesfin Y, Geze S, Nuriye K, Tefera B, Embiale A, et al. Preterm premature ruptures of membrane and factors associated among pregnant women admitted in Wolkite comprehensive specialized Hospital, Gurage Zone, Southern Ethiopia. Infect Dis Obstet Gynecol. 2021;2021(1):6598944.

Sultana N, Karim F, Rahman MK. Platelet to Lymphocyte Ratio as a New Inflammation Marker for the Preterm PROM. Sch Int J Obstet Gynec. 2023;6(10):394-9.

Peng L, Cao B, Hou F, Xu B, Zhou H, Liang L, et al. Relationship between platelet-to-lymphocyte ratio and lymphocyte-to-monocyte ratio with spontaneous preterm birth: a systematic review and meta-analysis. J Immunol Res. 2023;2023:6841344.

Balciuniene G, Kvederaite-Budre G, Gulbiniene V, Dumalakiene I, Viliene R, Pilypiene I, et al. Neutrophil-lymphocyte ratio for the prediction of histological chorioamnionitis in cases of preterm premature rupture of membranes: a case-control study. BMC Pregn Childb. 2021;21(1):656.

Lakshmi MS, Sravani VL. Role of neutrophil-lymphocyte ratio in determining the outcomes of preterm premature rupture of membranes. Int J Reprod Contracep Obstetr Gynecol. 2021;10(4):1617-21.

Sharami SH, Biazar G, Farzi F, Atrkarroushan Z, Ahmadi M, Chaibakhsh Y, et al. The association between platelets/lymphocyte ratio and premature rupture of membranes. Int J Women’s Heal Reproduct Sci. 2021;9(1):80-3.

Eriç Horasanlı J, Alp EC, Bülbül R. Evaluation of complete blood cell count parameters in the diagnosis of threatened preterm labor and premature rupture of membranes. Dubai Med J. 2022;5(3):157-62.

Uçkan K, Başkıran Y, Çeleğen İ. Association of subclinical markers of inflammation with preterm premature rupture of membranes and adverse neonatal results: a case control study. Arch Gynecol Obstetr. 2022;306(6):2063-8.

Kurban Y, Alan Y, Uyar İ, Atak Z, Aydemir Ö, Öktem A. Investigation of neutrophil/lymphocyte ratio and mean platelet volume in patients diagnosed with preterm labor. Paed Respir Revi. 2021;40:39-43.

Ozel A, Alici Davutoglu E, Yurtkal A, Madazli R. How do platelet-to-lymphocyte ratio and neutrophil-to-lymphocyte ratio change in women with preterm premature rupture of membranes, and threaten preterm labour? J Obstetr Gynaecol. 2020;40(2):195-9.

Esercan A, Demir I. Neutrophil/lymphocyte and platelet/lymphocyte ratio in preterm premature rupture of membranes. Cureus. 2023;15(5).

Rehman FU, Khan A, Aziz A, Iqbal M, bin zafar Mahmood S, Ali N. Neutrophils to lymphocyte ratio: Earliest and efficacious markers of sepsis. Cureus. 2020;12(10).

Carranza Lira S, García Espinosa M. Differences in the neutrophil/lymphocyte ratio and the platelet/lymphocyte ratio in pregnant women with and without COVID-19. Int J Gynaecol Obstet. 2022;157(2):296-302.

Islamoglu MS, Borku-Uysal B, Yavuzer S, Ikitimur H, Seyhan S, Koc S, et al. The diagnostic and predictive roles of neutrophil-lymphocyte ratio for severity of disease in COVID-19 patients. Clin Lab. 2021;67(12).

Herafteh S.Z, Nouri N, Peracheh M., Kikha N, Ghasemi M. Neutrophil to lymphocytes ratio and platelets to lymphocytes ratio in pre-eclampsia and normal pregnancy: A case-control study. Iran J Obstetr Gynecol Infert. 2020;23(9):61-8.

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Published

2024-06-28

How to Cite

Khodadost, M., Ghavami, Z., Dargahi, R., & Amani, F. (2024). Comparison of platelet to lymphocyte ratio and neutrophil to lymphocyte ratio in women with preterm premature rupture of membranes and women with preterm delivery. International Journal Of Community Medicine And Public Health, 11(7), 2632–2636. https://doi.org/10.18203/2394-6040.ijcmph20241816

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Original Research Articles