A study on household medicine wastage and disposal practices with screening of water samples for antibiotic presence in a South Indian district

Authors

  • Rosme David Department of Pharmacology, Amrita Institute of Medical Sciences, Kochi, Kerala, India
  • Mamatha Jayachandran Department of Pharmacology, Amrita Institute of Medical Sciences, Kochi, Kerala, India
  • Princy Louis Palatty Department of Pharmacology, Amrita Institute of Medical Sciences, Kochi, Kerala, India

DOI:

https://doi.org/10.18203/2394-6040.ijcmph20241839

Keywords:

Antibiotics, Antibiotic pollution, Household medicine, Medicine disposal, Surface water screening

Abstract

Background: Pharmaceuticals in the environment is known since last two decades. As hospitals and pharma industries, household medicines also need proper disposal otherwise they will gradually find their way into environment. So, we did a survey of residents in major metro city to understand their medicine wastage as well as disposal practices.

Methods: Pharmaceuticals in the environment is known since last two decades. As hospitals and pharma industries, household medicines also need proper disposal otherwise they will gradually find their way into environment. So, we did a survey of residents in major metro city to understand their medicine wastage as well as disposal practices.

Results: The water samples screened for antibiotic presence were all negative from 10 locations. A total population of 749 people, from 165 houses were included in the study. Leftover medicines were found in 75.8% houses, of which 5.36% houses had leftover antibiotics. Garbage disposal (58.2%) was the most commonly observed method of medicine disposal. Good attitude towards proper antibiotic disposal was independently significant with higher education (OR=2.5, 95% CI= 1.05-6.17), employment (OR=2.1, 95% CI= 1.05-4.3), and upper middle-class families (OR=2.4, 95% CI= 1.08-5.21).

Conclusions: Lack of proper guidelines for household medicine disposal across the country is reflected in our community too. Although this study could not detect antibiotics in the canal water, the emerging resistance pattern across the state reflects it could be there. Therefore, immediate action on medicine waste collections needs to be implemented.

References

Maharana S, Paul B, Dasgupta A, Garg S. Storage, reuse, and disposal of unused medications: A cross-sectional study among rural households of Singur, West Bengal. Int J Med Sci Public Heal. 2017;3(1):11-15

Amlund H, Berntssen MHG, Lunestad BT, Lundebye AK. Aquaculture feed contamination by persistent organic pollutants, heavy metals, additives and drug residues. Anim Feed Contam Eff Livest Food Saf. 2012;205-29.

Baudoin F, Hogeveen H, Wauters E. Reducing antimicrobial use and dependence in livestock production systems: a social and economic sciences perspective on an interdisciplinary approach. Front Vet Sci. 2021;8:584593.

Diwan V, Purohit M, Chandran S, Parashar V, Shah H, Mahadik VK, et al. A three-year follow-up study of antibiotic and metal residues, antibiotic resistance and resistance genes, focusing on Kshipra-A river associated with holy religious mass-bathing in India: Protocol paper. Int J Environ Res Public Health. 2017;14(6).

Foster HR, Burton GA, Basu N, Werner EE. Chronic exposure to fluoxetine (Prozac) causes developmental delays in Rana pipiens larvae. Environ Toxicol Chem. 2010;29(12):2845-50.

Zuccato E, Castiglioni S, Fanelli R, Bagnati R, Reitano G, Calamari D. Risks related to the discharge of pharmaceuticals in the environment: further research is needed. Pharm Environ. 2004;431-7.

Oaks JL, Gilbert M, Virani MZ, Watson RT, Meteyer CU, Rideout BA, et al. Diclofenac residues as the cause of vulture population decline in Pakistan. Nature. 2004;427(6975):630-3.

Kalasseril SG, Krishnan R, Vattiringal RK, Paul R, Mathew P, Pillai D. Detection of New Delhi Metallo-β-lactamase 1 and cephalosporin resistance genes among carbapenem-resistant enterobacteriaceae in water bodies adjacent to hospitals in India. Curr Microbiol. 2020;77(10):2886-95.

Hithesh I, Nisha B TJ. Practice of storage, reuse and disposal of unused medications among semi-urban households of Northern Tamil Nadu – a community based cross-sectional study. Int J Res Pharm Sci. 2020;11(2):1902-7.

Li N, Zhang X, Wu W, Zhao X. Occurrence, seasonal variation and risk assessment of antibiotics in the reservoirs in North China. Chemosphere. 2014;111(9):327-35.

Azanu D, Styrishave B, Darko G, Weisser JJ, Abaidoo RC. Occurrence and risk assessment of antibiotics in water and lettuce in Ghana. Sci Total Env. 2018;622:293-305.

Ding H, Wu Y, Zhang W, Zhong J, Lou Q, Yang P, et al. Occurrence, distribution, and risk assessment of antibiotics in the surface water of Poyang Lake, the largest freshwater lake in China. Chemosphere. 2017;184:137-47.

Castrignanò E, Kannan AM, Feil EJ, Kasprzyk-Hordern B. Enantioselective fractionation of fluoroquinolones in the aqueous environment using chiral liquid chromatography coupled with tandem mass spectrometry. Chemosphere. 2018;206:376-86.

Diwan V, Tamhankar AJ, Khandal RK, Sen S, Aggarwal M, Marothi Y, et al. Antibiotics and antibiotic-resistant bacteria in waters associated with a hospital in Ujjain, India. BMC Public Health. 2010;10.

Auta A, Omale S, Shalkur D, Abiodun AH. Unused medicines in Nigerian households: Types and disposal practices. J Pharmacol Pharmacother. 2011;2(3):195-6.

16. Zalpuri R, Singh R, Rawat L, Sharma JK. Review on the status of disposal practices of unused and expired medicines in India. Int J Innov Sci Eng Technol. 2021;8(3).

Sonowal S, Desai C, Kapadia J, Desai M. A survey of knowledge, attitude, and practice of consumers at a tertiary care hospital regarding the disposal of unused medicines. J Basic Clin Pharm. 2017;8(1):4.

Narwat A, Sindhu A. Practice towards disposal of medicines (unused/expired drugs) among the patients visiting tertiary care teaching hospital in Haryana, India. Int J Res Med Sci. 2019;7(8):3050.

Alkhalifah HM, Alkhalifah KM, Alharthi AF, Elzahrany YR, Aljuhani MA. Knowledge, attitude and practices towards antibiotic use among patients attending Al Wazarat health center. J Fam Med Prim Care. 2022;11(4):1299-307.

Karuniawati H, Hassali MAA, Suryawati S, Ismail WI, Taufik T, Hossain MS. Assessment of knowledge, attitude, and practice of antibiotic use among the population of boyolali, indonesia: A cross-sectional study. Int J Environ Res Public Health. 2021;18(16).

Awad AI, Aboud EA. Knowledge, attitude and practice towards antibiotic use among the public in Kuwait. PLoS One. 2015;10(2):1-15.

Bhardwaj K, M SS, Baliga S, Unnikrishnan B, Baliga BS. Knowledge, attitude, and practices related to antibiotic use and resistance among the general public of coastal south Karnataka, India – A cross-sectional survey. Clin Epidemiol Glob Heal. 2021;11(October 2020):100717.

Raupach-Rosin H, Rübsamen N, Schütte G, Raschpichler G, Chaw PS, Mikolajczyk R. Knowledge on antibiotic use, self-reported adherence to antibiotic intake, and knowledge on multi-drug resistant pathogens -results of a population-based survey in lower saxony, Germany. Front Microbiol. 2019;10(APR):1-8.

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Published

2024-06-28

How to Cite

David, R., Jayachandran, M., & Palatty, P. L. (2024). A study on household medicine wastage and disposal practices with screening of water samples for antibiotic presence in a South Indian district. International Journal Of Community Medicine And Public Health, 11(7), 2787–2793. https://doi.org/10.18203/2394-6040.ijcmph20241839

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Original Research Articles