Incidence of human rabies following bite or exposure to laboratory confirmed rabid animals

Authors

  • Kanwarpreet S. Sandhu Department of Public Health, Guru Angad Dev Veterinary and Animal Sciences University, Ludhiana, Punjab, India
  • Pahul K. Bawa Sri Guru Ramdas University of Health Sciences, Amritsar, Punjab, India
  • Bhupinder S. Sandhu Department of Veterinary Pathology, Guru Angad Dev Veterinary and Animal Sciences University, Ludhiana, Punjab, India

DOI:

https://doi.org/10.18203/2394-6040.ijcmph20241312

Keywords:

Epidemiology, Dog bite, dFAT, Incidence, India, Rabies

Abstract

Background: Rabies is one of the important endemic fatal zoonotic viral disease afflicting humans and animals in Punjab, India. The present study investigated the incidence of rabies in humans bitten/exposed to laboratory confirmed rabid animals, as well as incidence after use of vaccine or rabies immunoglobulin (RIG) and clinico-epidemiological studies.

Methods: A study was conducted during August 2021 to September 2022 on forty (40) rabies suspected animals presented to diagnose rabies by direct fluorescent antibody test (dFAT) at rabies diagnostic laboratory (RDL), Guru Angad Dev Veterinary and Animal Sciences University (GADVASU), Punjab, India. A detailed questionnaire was prepared for obtaining information about exposure/bite of humans by rabid animals, death of humans, demographic and epidemiological information of victims.

Results: Out of total forty (40) suspected rabies cases, 30(75%) were found positive for rabies by dFAT. Laboratory confirmed rabies (LCR) incidence was 60.80% and 21.73% in stray and pet dogs, respectively. All pet dogs were vaccinated but no stray dog was vaccinated. The LCR incidence in buffaloes and cattle was 77.77% and 100%, respectively. Further in humans exposed to rabid animals (59), males were at more risk than females. The human rabies incidence was 3.38% (2/59). Highest incidence of dog bites in adult males on lower limb was observed from urban stray dogs (60.80%) followed by children. Post exposure vaccination was given to 98.3% humans exposed to rabid animals. Human’s rabies in two cases was due to no vaccination or RIG.

Conclusions: Vaccination is an important step in controlling rabies in India. There is a need for integrated and comprehensive management of street dogs and bite management.

 

References

Ma X, Bonaparte S, Toro M, Orciari LA, Gigante CM, Kirby JD, et al. Rabies surveillance in the United States during 2020. J Am Vet Med Assoc. 2022;260(10):1157-65.

Pringle CR. The Order Mononegavirales. Arch Virol. 1991;117:137-40.

Hampson K, Coudeville L, Lembo T, Sambo M, Kieffer A, Attlan M, et al. Estimating the global burden of endemic canine rabies. PLOS Negl Trop Dis. 2015;9(4):e0003709.

World Health Organization (WHO). World Survey of Rabies, No. 35 for the year 1999. Available at: https://www.who.int/news-room/fact-sheets/detail/ rabies/?gad_source=1&gclid=CjwKCAjwupGyBhBBEiwA0UcqaEvKwBGgZ5CJXl4uEPPX0bC-rKdPqz6oPjcQPsKUHlJIw3c_8uvUSBoCfL8QAvD_BwE. Accessed on 03 January 2024.

MacBean CE, Taylor DM, Ashby K. Animal and human bite injuries in Victoria, 1998-2004. Med J Aust. 2007;186(1):38.

Satapathy DM, Behera TR. Rabies and current concepts in its prevention. Assoc Prev Control Rabies India J. 2005;6:38-41.

Joseph J, Sangeetha N, Khan AM, Rajoura O. Determinants of delay in initiating post-exposure prophylaxis for rabies prevention among animal bite cases: hospital-based study. Vaccine. 2013;32:74-8.

World Health Organization. Expert Consultation on Rabies met in Bangkok, Thailand, on 2005. World Health Organ Tech Rep Ser. 2005;931:1-88.

Taylor LH, Hampson K, Fahrion A, Abela Ridder B, Nel LH. Difficulties in estimating the human burden of canine rabies. Acta Tropica. 2017;165:133-40.

Gill GS, Singh BB, Dhand NK, Aulakh RS, Sandhu BS, Ward MP, et al. Estimation of the incidence of animal rabies in Punjab, India. PLoS One. 2019;4(9):e0222198.

Meslin FX, Kaplan, Martin M, Koprowski H. Laboratory techniques in rabies, 4th Edition. Geneva: World Health Organization. 1996. Available at: http://www.who.int/iris/handle/10665/38286. Accessed on 03 January 2024.

Luna LG. Manual of histologic staining methods, 3rd, Armed Forces Institute of Pathology, McGraw-Hill Toronto. 1968.

Warner CK, Whitfield SG, Fekadu M, Ho H. Procedures for reproducible detection of rabies virus antigen mRNA and genome in situ in formalin-fixed tissues. J Virol Methods. 1997;67:5-12.

Sambo MB. Epidemiological dynamics of rabies in Tanzania and its impacts on local communities: University of Glasgow. 2012.

Zoonotic Disease Unit (ZDU) Kenya. In: Ministry of Health and Ministry of Agriculture LaF, editor. Strategic Plan for the Elimination of Human Rabies in Kenya 2014–2030. 2014.

Goel K, Sen A, Satapathy P, Kumar P, Aggarwal A K, Sah R, et al. Emergence of rabies among vaccinated humans in India: a public health concern. The Lancet Regional Health - Southeast Asia. 2023;9:100109.

Jemberu WT, Molla W, Almaw G, Alemu S. Incidence of rabies in humans and domestic animals and people’s awareness in North Gondar zone, Ethiopia. PLOS Negl Trop Dis. 2013;7(5):e2216.

Kayali U, Mindekemb R, Ye´madji N, Oussigue´re´ A, Na¨ıssengar S, Ndoutamia AG, et al. Incidence of canine rabies in N’Djame´na, Chad. Prev Vet Med. 2003;61:227-33.

John D, Royal A, Bharti O. Burden of illness of dog-mediated rabies in India: A systematic review. Clin Epidemiol Glob Health. 2021;12:100804.

Brookes VJ, Gill GS, Singh BB, Sandhu BS, Dhand NK, Aulakh RS, et al. Challenges to human rabies elimination highlighted following a rabies outbreak in bovines and a human in Punjab, India. Zoonoses Public Health. 2019;66(3):325-36.

Singh CK, Sandhu BS. Epidemiological investigation of Rabies in Punjab. Indian J Anim Sci. 2007;77(8):653-8.

Sudarshan MK, Madhusudan SN, Mahendra BJ, Rao NSN, Ashwath Narayana DH, Abdul Rahman S, et al. Assessing the burden of human rabies in India: results of a national multi-center epidemiological survey. Int J Infect Dis. 2007;11:29-35.

Paulos A, Eshetu Y, Bethelhem N, Abebe B, Badeg Z, et al. A study on the prevalence of animal rabies in Addis Ababa during 1999–2002: Ethiop Vet J. 2002;7:69-77.

Centre for food security and public health (CFSPH) Rabies. Centre for food security and public health. College of veterinary medicine, Iowa state university; Ames, Iowa. 2009. Available at: http:// www.cfsph. iastate.edu/Factsheets/pdfs/rabies.pdf. Accessed on 03 January 2024.

Sudarshan MK, Nagaraj S, Savitha B, Veena SG. An epidemiological study of rabies in Bangalore city. J Indian Med Assoc. 1995;93:14-6.

Gohil HK, Dhillon R, Tiwari KN. Human rabies situation in and around Delhi. J Assoc Prev Control Rabies India. 2003;182:11-5.

Simani S, Fayaz A, Rahimi P, Eslami N, Howeizi N, Biglari P. Six fatal cases of classical rabies virus without biting incidents, Iran 1990-2010. J Clin Virol. 2012;54:251-4.

DandaleM, Singh C K, RamneekV, Deka D, Sandhu B S, Bansal K, et al. Nested RT-PCR for ante mortem diagnosis of rabies from body secretion/excretion of animals suspected for rabies. Vet World. 2012;5(11):690-3.

Singh CK, Sandhu BS. Rabies in South Asia: epidemiological investigations and clinical perspective. Dev Biol (Basel). 2008;131:133-6.

Daniels DM, Ritzi RBS, O’Neil J, Scherer LRT. Analysis of nonfatal dog bites in children. J Trauma Inj Infect Crit Care. 2008;66:S17-22.

Tenzin, Dhand NK, Gyeltshen T, Firestone S, Zangmo C, et al. Dog Bites in Humans and Estimating Human Rabies Mortality in Rabies Endemic Areas of Bhutan. PLoS Negl Trop Dis. 2011;5(11):e1391.

Sriaroon C, Sriaroon P, Daviratanasilpa S, Khawplod P, Wilde H. Retrospective: animal attacks and rabies exposures in Thai children. Travel Med Infect Dis. 2006;4(5):270-4.

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Published

2024-05-21

How to Cite

Sandhu, K. S., Bawa, P. K., & Sandhu, B. S. (2024). Incidence of human rabies following bite or exposure to laboratory confirmed rabid animals. International Journal Of Community Medicine And Public Health, 11(6), 2254–2261. https://doi.org/10.18203/2394-6040.ijcmph20241312

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Original Research Articles