Celiac disease in children with failure to thrive and our experience in a tertiary care hospital of Kashmir in north India

Junaid Mehraj; Mukhtar Ahmad; Mudawar Saleem Beigh; Sheikh Nisar Ahmad; Owais Ahmad Mir; Naseer Yousuf Mir

doi:10.18203/2394-6040.ijcmph20241490

Authors

Junaid Mehraj Department of Paediatrics, SKIMS Medical College Bemina Srinagar, J&K, India
Mukhtar Ahmad Department of Paediatrics, SKIMS Medical College Bemina Srinagar, J&K, India
Mudawar Saleem Beigh Department of Paediatrics, SKIMS Medical College Bemina Srinagar, J&K, India
Sheikh Nisar Ahmad Department of Paediatrics, SKIMS Medical College Bemina Srinagar, J&K, India
Owais Ahmad Mir Department of Paediatrics, SKIMS Medical College Bemina Srinagar, J&K, India
Naseer Yousuf Mir Department of Paediatrics, Government Medical College Handwara, J&K, India Department of Paediatrics, SKIMS Medical College Bemina Srinagar, J&K, India

DOI:

https://doi.org/10.18203/2394-6040.ijcmph20241490

Keywords:

Anti-gliadin antibodies, Failure to thrive, Histopathological examination, Weight loss

Abstract

Background: Celiac disease (CD) is an autoimmune gastrointestinal disease caused by intolerance to gluten. Celiac disease is an important cause of failure to thrive in children. In addition to intestinal and extra intestinal clinical features, the diagnosis of CD is based up on histological findings in duodenal or jejunal biopsies, which may present in various forms.

Methods: The study was a prospective observational, cohort study, including all children between 2-18 yrs. of age presented with failure to thrive fulfilling criterias of study. The patients with increased levels of IgA anti tTGA were selected for upper gastrointestinal endoscopy and duodenal biopsy. The aim of study is to study the prevalence and clinical profile of CD in children with failure to thrive.

Results: A total of 66 cases of failure to thrive/short stature were enrolled, with prevalence of 24.2% of CD. Male: Female ratio was 1:1 in children with CD. Clinical features include weight loss (62.5%), irritability (37.5%), anemia (37.5%), diarrhea (37.5%). On biopsy cases 87.5% cases of failure to thrive had Marsh grading of grade 3 and 12.5% had Marsh grade 2.

Conclusions: Failure to thrive patients with diarrhea and anemia should be evaluated upfront for celiac disease.

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