Relevance of copper/zinc ratio and its association with redox status in chronic obstructive pulmonary disease

Authors

  • Sonu Das Department of Zoology, St. Thomas College, Kottayam, Kerala, India
  • Mathew John Department of Biochemistry and Phytochemistry, Jubilee Centre for Research, Jubilee Mission Medical College, Thrissur, Kerala, India
  • Supriya Adiody Department of Pulmonology, Jubilee Mission Medical College, Thrissur, Kerala, India

DOI:

https://doi.org/10.18203/2394-6040.ijcmph20241487

Keywords:

Copper/zinc ratio, COPD exacerbation, Occupational exposure, Oxidative stress index

Abstract

Background: Chronic obstructive pulmonary disease is a progressive and persistent inflammatory condition associated with significant morbidity and mortality. Increased oxidative stress amongst others, plays an important role in the pathogenesis of this disease. The objective of the present study was to conduct a preliminary yet comprehensive examination of metal exposure specifically copper and zinc levels and their association with overall oxidative stress in COPD.

Methods: A cross sectional study was carried out in a tertiary care hospital in South India. Two groups were included in the study. One group with 20 COPD patients and the other group of 20 healthy controls. Plasma samples were obtained from both the groups and serum levels of copper and zinc were studied by atomic absorption spectrometry. Cu/Zn ratio obtained from the results was further correlated with oxidative stress index calculated from total oxidant status and total antioxidant status in COPD with respect to controls.

Results: The copper levels were significantly higher and the zinc levels lower in the COPD group as compared to the control group. The copper/zinc ratio was higher in COPD as compared to control population. The correlation between Cu/Zn ratio and oxidative stress index showed a positive correlation with a regression coefficient of 0.7.

Conclusions: The study throws light on the trace element imbalance in COPD and how these could induce oxidative stress, contributing to persistent inflammation in COPD. In the clinical perspective, monitoring Cu/Zn ratio in COPD patients may lead to better risk mitigation and thereby better therapeutic management of the disease.

Metrics

Metrics Loading ...

References

Yang IA, Jenkins CR, Salvi SS. Chronic obstructive pulmonary disease in never-smokers: risk factors, pathogenesis, and implications for prevention and treatment. Lancet Respi Medi. 2022;10(5):497-511.

Orozco-Levi M, Garcia-Aymerich J, Villar J, Ramirez-Sarmiento A, Anto JM, Gea J. Wood smoke exposure and risk of chronic obstructive pulmonary disease. Euro Resp J. 2006;27(3):542-6.

3. Kunutsor SK, Voutilainen A, Laukkanen JA. Serum copper-to-zinc ratio and risk of chronic obstructive pulmonary disease: a cohort study. Lung. 2023;201(1):79-84.

Valkova E, Atanasov V, Vlaykova T, Tacheva T, Zhelyazkova Y, Dimov D, et al. The serum levels of the heavy metals Cu, Zn, Cd, and Pb and progression of COPD-a preliminary study. Int J Environm Res Publ Heal. 2023;20(2):1427.

Erel O. A new automated colorimetric method for measuring total oxidant status. Clin Biochem. 2005;38(12):1103-11.

Pham AN, Xing G, Miller CJ, Waite TD. Fenton-like copper redox chemistry revisited: Hydrogen peroxide and superoxide mediation of copper-catalyzed oxidant production. J Catalys. 2013;301:54-64.

Lloyd DR, Phillips DH. Oxidative DNA damage mediated by copper (II), iron (II) and nickel (II) Fenton reactions: evidence for site-specific mechanisms in the formation of double-strand breaks, 8-hydroxydeoxyguanosine and putative intrastrand cross-links. Mut Res/Fundam Molecul Mecha Mutagen. 1999;424(1-2):23-36.

Uriu-Adams JY, Keen CL. Copper, oxidative stress, and human health. Molec Asp Medi. 2005;26(4-5):268-98.

Wen X, Liu Y, Bai Y, Li M, Fu Q, Zheng Y. LOXL2, a copper-dependent monoamine oxidase, activates lung fibroblasts through the TGF-β/Smad pathway. Int J Mole Medic. 2018;42(6):3530-41.

Behtash F, Abedini F, Ahmadi H, Mosavi SB, Aghaee A, Morshedloo MR, Lorenzo JM. Zinc application mitigates copper toxicity by regulating Cu uptake, activity of antioxidant enzymes, and improving physiological characteristics in summer squash. Antioxidants. 2022;11(9):1688.

Kırkıl G, Muz MH, Seçkin D, Şahin K, Küçük Ö. Antioxidant effect of zinc picolinate in patients with chronic obstructive pulmonary disease. Res Medi. 2008;102(6):840-4.

Luan R, Ding D, Xue Q, Li H, Wang Y, Yang J. Protective role of zinc in the pathogenesis of respiratory diseases. Euro J Clin Nutrit. 2023;77(4):427-35.

Ivanova ID, Pal A, Simonelli I, Atanasova B, Ventriglia M, Rongioletti M, et al. Evaluation of zinc, copper, and Cu: Zn ratio in serum, and their implications in the course of COVID-19. J Trace Elem Medic Biol. 2022;71:126944.

Heller RA, Sun Q, Hackler J, Seelig J, Seibert L, Cherkezov A, et al. Prediction of survival odds in COVID-19 by zinc, age and selenoprotein P as composite biomarker. Redox Biol. 2021;38:101764.

Mezzetti A, Pierdomenico SD, Costantini F, Romano F, De Cesare D, Cuccurullo F, et al. Copper/zinc ratio and systemic oxidant load: effect of aging and aging-related degenerative diseases. Free Radi Biol Medi. 1998;25(6):676-81.

Zinellu E, Zinellu A, Fois AG, Carru C, Pirina P. Circulating biomarkers of oxidative stress in chronic obstructive pulmonary disease: a systematic review. Respir Res. 2016;17:1-1.

Maury J, Gouzi F, De Rigal P, Heraud N, Pincemail J, Molinari N, et al. Heterogeneity of systemic oxidative stress profiles in COPD: a potential role of gender. Oxidat Medi Cell Long. 2015;2015.

Downloads

Published

2024-05-30

How to Cite

Das, S., John, M., & Adiody, S. (2024). Relevance of copper/zinc ratio and its association with redox status in chronic obstructive pulmonary disease. International Journal Of Community Medicine And Public Health, 11(6), 2291–2295. https://doi.org/10.18203/2394-6040.ijcmph20241487

Issue

Section

Original Research Articles