Metabolomic insights into plant-derived cyclolinopeptides as natural therapeutics for management of paroxysmal hypertension: an in-silico approach

Akanksha Mishra; Rahul Shrivastava; Ruchi Khare

doi:10.18203/2394-6040.ijcmph20242187

Authors

Akanksha Mishra Department of Biotechnology, Madhya Pradesh Council of Science and Technology, Vigyan Bhawan, Nehru Nagar, Bhopal, Madhya Pradesh, India
Rahul Shrivastava Department of Biological Science and Engineering, Maulana Azad National Institute of Technology, Bhopal, India
Ruchi Khare Department of Biological Science and Engineering, Maulana Azad National Institute of Technology, Bhopal, India

DOI:

https://doi.org/10.18203/2394-6040.ijcmph20242187

Keywords:

Cyclolinopeptides, Metabolic pathway, Molecular docking, Na /K pumps, Paroxysmal hypertension

Abstract

Paroxysmal hypertension is a type of response exerted by the body towards external stimulus like physical, mental, or emotional stress which leads to chemical changes in the body that accelerates the physiological parameters like stress hyper-glycemia, obesity, stress cardiomyopathy, hemorrhagic stroke etc. Due to ill effects of chemical drugs administered by the clinicians, there is need of natural anti-depressant products which may serve as an alternative medicine. Compounds like cyclolinopeptides, cyclosporin A, and curcacyclines have exhibited potential immunosuppressive activity. With objective of drug discovery, this study investigates the role of sub-types of cyclolinopeptides as potential drugs against paroxysmal hypertension and predict their mode of action in biochemical pathways and their role in mitigation of stress induced hyper response.

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