Diabetes and the retinal changes in the eye: a threat to the sight

Authors

  • Namrata Srivastava Department of Optometry, ERA University of Allied Health Science, Lucknow, Uttar Pradesh, India https://orcid.org/0000-0003-1798-2891
  • Mahesh Chandra Dr. Shushila Tiwari Hospital and Government Medical College, Haldwani, Uttarakhand, India
  • Nitesh Department of Ophthalmology, Satya Eye Hospital and Research Institute, Kanpur, Uttar Pradesh, India

DOI:

https://doi.org/10.18203/2394-6040.ijcmph20240301

Keywords:

Diabetic retinopathy, Glucose level, Vision loss, Laser surgery, Injections, Vitrectomy

Abstract

This article discusses the importance of diabetic retinopathy, an eye disease associated with diabetes, which is a systemic disease. The research question addresses the impact of diabetes on the retina of the eye through infection and clinical features. This approach is designed to improve the relationship between early diagnosis and treatment of disease, including laser surgery, corticosteroid injections, and vitrectomy. This article focuses on chronic diabetic retinopathy and eye examination recommendations in the United States and the United Kingdom. To prevent and manage diabetic retinopathy, it is recommended that diabetic patients have regular eye examinations. The results of this study include the importance of good glycaemic control, injections, photocoagulation, and vitrectomy as treatment options. Intravitreal long-acting steroids may also temporarily improve visual acuity by reducing macular oedema. However, long-term use of the drug may cause side effects and may lead to cataracts, steroid glaucoma, and endophthalmitis. It may cause reasons. A recent study of the disease in India shows that the incidence of high blood sugar and its effects on the eye is mainly diabetic retinopathy, including cataracts, neovascular glaucoma and even retinal detachment, which are very dangerous for eye health. Therefore, it is important to inform patients about this disease and perform timely screening because patients need to be informed carefully.

References

National Eye Institute, National Institutes of Health. Diabetic Retinopathy: What You Should Know. 2019. Available at: https://www.nei.nih.gov/learn-about-eye-health/eye-conditions-and-diseases/ diabetic-retinopathy#:~:text=Diabetic%20retino pathy%20is%20an%20eye,the%20back%20of%20your%20eye). Accessed on 24 November 2023.

National Eye Institute, National Institutes of Health. Facts about Diabetic Eye Disease. Available at: https://www.nei.nih.gov/learn-about-eye-health/out reach-resources/diabetic-eye-disease-resources#: ~:text=Diabetic%20eye%20disease%20at%20a%20glance&text=Having%20diabetes%20increases%20the%20risk,)%2C%20cataract%2C%20and%20glaucoma. Accessed on 24 November 2023.

Forrest IS, Chaudhary K, Paranjpe I, Vy HMT, Marquez-Luna C, Rocheleau G, et al. Genome-wide polygenic risk score for retinopathy of type 2 diabetes. Hum Mol Genet. 2021;30(10):952-60.

NHS Choices. Diabetic eye screening. 2016. Available at: https://www.nhs.uk/conditions/ diabetic-eye-screening/. Accessed on 24 November 2023.

Solomon SD, Chew E, Duh EJ, Sobrin L, Sun JK, Vander Beek BL, et al. Diabetic Retinopathy: A Position Statement by the American Diabetes Association. Diabetes Care. 2017;40(3):412-8.

Liu Y, Swearingen R. Diabetic Eye Screening: Knowledge and Perspectives from Providers and Patients. Curr Diab Rep. 2017;17(10):94.

Nsiah-Kumi P, Ortmeier SR, Brown AE. Disparities in diabetic retinopathy screening and disease for racial and ethnic minority populations--a literature review. J Natl Med Assoc. 2009;101(5):430-7.

Lawrenson JG, Graham-Rowe E, Lorencatto F, Burr J, Bunce C, Francis JJ, et al. Interventions to increase attendance for diabetic retinopathy screening. Cochrane Database Syst Rev. 2018;1(1):CD012054.

Masharani U. Diabetes Ocular complications. Chronic Complications of Diabetes. Armenian Medical Network. 2006.

News-Medical Life Sciences. Diabetes and Vision. Available at: https://www.news-medical.net/health/ Diabetes-and-Vision.aspx. Accessed on 24 November 2023.

Cleveland Clinic. Diabetes. Available at: my.clevelandclinic.org/health/diseases/7104-diabetes-mellitus-an-overview. Accessed on 24 November 2023.

World Health Organization. Diabetes. Available at: who.int/news-room/fact-sheets/detail/diabetes. Accessed on 24 November 2023.

Centers for Disease Control and Prevention. What is Diabetes? Available at: https://www.cdc.gov/ diabetes/basics/diabetes.html#:~:text=Diabetes%20is%20a%20chronic%20(long,your%20pancreas%20to%20release%20insulin. Accessed on 24 November 2023.

World Health Organization. Diabetes. Available at: who.int/news-room/fact-sheets/detail/diabetes. Accessed on 24 November 2023.

Non-proliferative Diabetic Retinopathy (Includes Macular Edema). Available at: https://www.healthline.com/health/diabetes/non-proliferative-diabetic-retinopathy. Accessed on 24 November 2023.

Xu H, Curtis T, Stitt A. Pathophysiology and Pathogenesis of Diabetic Retinopathy. Diapedia, The Living Textbook of Diabetes. 2014.

Pardianto G. Understanding diabetic retinopathy. Mimbar Ilmiah Oftalmologi Indonesia. 2005;2:65-6.

Bek T. Experimental Approaches to Diabetic Retinopathy – Front Diabetes. In Hammes HP, Porta M, editors. Clinical Presentations and Pathological Correlates of Retinopathy. 2010;20:1-19.

Brownlee et al. 2020, "Clinical features of diabetic retinopathy". Available at: https://www.nejm.org/doi/full/10.1056/NEJMra1005073. Accessed on 24 November 2023.

Centers for Disease Control and Prevention. Vision Loss. Available at: https://www.cdc.gov/vision health/basic_information/vision_loss.htm. Accessed on 24 November 2023.

Macular Edema. National Eye Institute. Available at: https://www.nei.nih.gov/learn-about-eye-health/eye-conditions-and-diseases/macular-edema. Accessed on 24 November 2023.

Kulkarni AD, Michael S. Diabetic macular edema: therapeutic options. Diabetes Ther. 2012;3(1):1-14.

Future Learn. Stages of Diabetic Retinopathy: The ICO Classification. Available at: futurelearn. com/info/courses/diabetic-eye-disease/0/steps/ 47627. Accessed on 24 November 2023.

Goldberg MF, Jampol LM. Knowledge of diabetic retinopathy before and 18 years after the Airlie House Symposium on Treatment of Diabetic Retinopathy. Ophthalmology. 1987;94:741-6.

Diabetic retinopathy study. Report Number 6. Design, methods, and baseline results. Report Number 7. A modification of the Airlie House classification of diabetic retinopathy. Prepared by the Diabetic Retinopathy. Invest Ophthalmol Vis Sci. 1981;21:1-226.

Grading diabetic retinopathy from stereoscopic color fundus photographs--an extension of the modified Airlie House classification. ETDRS report number 10. Early Treatment Diabetic Retinopathy Study Research Group. Ophthalmology. 1991;98:786-806.

Bresnick GH. Diabetic macular edema. A review. Ophthalmology. 1986;93:989-97.

Classification of diabetic retinopathy from fluorescein angiograms. ETDRS report number 11. Early Treatment Diabetic Retinopathy Study Research Group. Ophthalmology. 1991;98:807-22.

Huang D, Swanson EA, Lin CP, Schuman JS, Stinson WG, Chang W, et al. Optical coherence tomography. Science. 1991;254:1178-81.

Kim BY, Smith SD, Kaiser PK. Optical coherence tomographic patterns of diabetic macular edema. Am J Ophthalmol. 2006;142:405-12.

Wilkinson CP, Ferris FL, Klein RE, Lee PP, Agardh CD, Davis M, et al. Proposed international clinical diabetic retinopathy and diabetic macular edema disease severity scales. Ophthalmology. 2003;110:1677-82.

Ferris F. Early photocoagulation in patients with either type I or type II diabetes. Trans Am Ophthalmol Soc. 1996;94:505-37.

Murphy RP. Management of diabetic retinopathy. Am Fam Physician. 1995;51:785-96.

Mandecka A, Dawczynski J, Vilser W, Blum M, Müller N, Kloos C, et al. Abnormal retinal autoregulation is detected by provoked stimulation with flicker light in well-controlled patients with type 1 diabetes without retinopathy. Diabetes Res Clin Pract. 2009;86(1):51-5.

Bettermann K, Slocomb J, Shivkumar V, Quillen D, Gardner TW, Lott ME. Impaired Retinal Vasoreactivity: An Early Marker of Stroke Risk in Diabetes. J Neuroimaging. 2017;27(1):78-84.

NHS. Diabetic retinopathy. Available at: nhs.uk/conditions/diabetic-retinopathy/treatment. Accessed on 24 November 2023.

Virgili G, Parravano M, Evans JR, Gordon I, Lucenteforte E. Anti-vascular endothelial growth factor for diabetic macular oedema: A network meta-analysis. Cochrane Database Systematic Rev. 2018;10(10):CD007419.

Rittiphairoj T, Mir TA, Li T, Virgili G. Intravitreal steroids for macular edema in diabetes. Cochrane Database Syst Rev. 2020;11(11):CD005656.

Kertes PJ, Johnson TM. Evidence based eye care. Lippincott Williams & Wilkins. 2007.

Amoroso F, Pedinielli A, Astroz P, Semoun O, Capuano V, Miere A, et al. Comparison of pain experience and time required for pre-planned navigated peripheral laser versus conventional multispot laser in the treatment of diabetic retinopathy. Acta Diabetologica. 2019;57(5):535-41.

Chhablani J, Mathai A, Rani P, Gupta V, Arevalo JF, Kozak I. Comparison of conventional pattern and novel navigated panretinal photocoagulation in proliferative diabetic retinopathy. Invest Ophthalmol Vis Sci. 2014;55(6):3432-8.

Mayo Clinic. Diabetic retinopathy. Available at: http://mayoclinic.org/diseases-conditions/diabetic-retinopathy/doctors-departments/ddc-20371618. Accessed on 24 November 2023.

Noctura. Sleep Mask for diabetic retinopathy. NIHR innovation observatory. Retrieved 2022/2/15 p. 400.

Powell, S. No long-term therapeutic benefit. Available at: https://www.nice.org.uk/advice/ mib144. Accessed on 24 November 2023.

Bhatt MP, Lim YC, Ha KS. C-peptide replacement therapy as an emerging strategy for preventing diabetic vasculopathy. Cardiovasc Res. 2014;104(2):234-44.

AdisInsight. C-peptide – Creative peptides. Available at: https://adisinsight.springer.com/drugs/8000104 30. Accessed on 24 November 2023.

Kramerov AA, Ljubimov AV. Stem cell therapies in the treatment of diabetic retinopathy and keratopathy. Exp Biol Med (Maywood). 2016;241(6):559-68.

Sivaprasad S, Arden G. Spare the rods and spoil the retina: Revisited. Eye. 2016;30(2):189-92.

Noctura. Sleep Mask for diabetic retinopathy. NIHR innovation observatory. Available at: https://www. nice.org.uk/advice/mib144. Accessed on 24 November 2023.

Powell S. No long-term therapeutic benefit from £250 mask. Available at: https://www.aop. org.uk/ot/science-and-vision/research/2018/03/ 16/no-long-term-therapeutic-benefit-from-250-mask. Accessed on 24 November 2023.

Amoroso F, Pedinielli A, Astroz P, Semoun O, Capuano V, Miere A, et al. Comparison of pain experience and time required for pre-planned navigated peripheral laser versus conventional multispot laser in the treatment of diabetic retinopathy. Acta Diabetologica. 2019;57(5):535-41.

Antoszyk AN, Glassman AR, Beaulieu WT, Jampol LM, Jhaveri CD, Punjabi OS, et al. Effect of Intravitreous Aflibercept vs Vitrectomy With Panretinal Photocoagulation on Visual Acuity in Patients With Vitreous Hemorrhage From Proliferative Diabetic Retinopathy: A Randomized Clinical Trial. JAMA. 2020;324(23):2383-95.

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Published

2024-01-31

How to Cite

Srivastava, N., Chandra, M., & Nitesh. (2024). Diabetes and the retinal changes in the eye: a threat to the sight. International Journal Of Community Medicine And Public Health, 11(2), 1030–1037. https://doi.org/10.18203/2394-6040.ijcmph20240301

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Section

Review Articles