Definition, epidemiology and characterization of sepsis


  • Ahmed Amin Aljefri Department of Emergency Medicine, Al Thager Hospital, Jeddah, Saudi Arabia
  • Latifah Humoud Almutairi Department of Anesthesia, Farwaniya Hospital, Kuwait City, Kuwait
  • Manar Hassan Alraddadi Emergency Medical Services, Hera General Hospital, Mecca, Saudi Arabia
  • Shahad Ali Alahmadi College of Medicine, King Abdulaziz University, Jeddah, Saudi Arabia
  • Ali Qasem Sufyani Department of Respiratory Therapy, Jazan General Hospital, Jazan, Saudi Arabia
  • Jawad Najeeb Almarzooq Department of Emergency Medicine, Prince Saud bin Jalawi Hospital, Al Ahsa, Saudi Arabia
  • Ahmed Hassan Al Nashri Department of Internal Medicine, South Qunfudah Hospital, Al Qunfudhah, Saudi Arabia
  • Fatimah Abdulhameed Al Wosaibi College of Medicine, Arabian Gulf University, Manama, Bahrain
  • Norah Ali Boukhamssein College of Medicine, Arabian Gulf University, Manama, Bahrain
  • Mustafa Saeed Almahasnah Department of Internal Medicine, Alkhafji General Hospital, Al Khafji, Saudi Arabia
  • Saja Dhawi Alyami Department of Critical Care Unit, King Fahad Armed Forces Hospital, Khamis Mushit, Saudi Arabia



Sepsis, Systemic inflammatory response syndrome, Clinical manifestations, Multidisciplinary management, Post-sepsis syndrome


Sepsis is a condition that occurs when the body's response to infection becomes unbalanced and potentially life-threatening. In this study, there is a focus on understanding and addressing sepsis. This detailed review explores how sepsis is defined in its prevalence in populations and how it is present clinically. The development of sepsis involves a series of events triggered by infections resulting in inflammation and dysfunction in organs. The symptoms of sepsis can range from signs like fever and changes in state to more severe complications such as septic shock. Early recognition of these symptoms using criteria like Systemic inflammatory response syndrome (SIRS) is crucial for intervention, which can greatly impact patient outcomes. Various diagnostic markers, imaging techniques and a deeper understanding of the pathophysiology behind sepsis have contributed to identification and targeted treatment approaches. Managing sepsis involves a combination of therapy, support for blood circulation, respiratory interventions and careful use of agents that modulate the system. It's important to emphasize the efforts among healthcare professionals from disciplines when it comes to managing sepsis effectively. Providing follow up care is essential for survivors as they may experience long term consequences such as sepsis syndrome. Due to its impact on health ongoing research is necessary to explore therapeutic options and refine existing strategies for managing sepsis effectively. The field continues to evolve with advancements, in precision medicine host directed therapies and interdisciplinary collaboration playing roles. This review seeks to grasp the concept of sepsis, providing insights into its various aspects, including the difficulties, in diagnosis and the ever-evolving treatment strategies.


Wu AL, Wu WC. Anti-VEGF for ROP and Pediatric Retinal Diseases. Asia Pac J Ophthalmol (Phila). 2018;7(3):145-51.

Delano MJ, Ward PA. The immune system's role in sepsis progression, resolution, and long-term outcome. Immunol Rev. 2016;274(1):330-3.

Fujishima S. Organ dysfunction as a new standard for defining sepsis. Inflamm Regen. 2016;36:24.

Chen J, Wei H. Immune Intervention in Sepsis. Front Pharmacol. 2021;12:718089.

Mayr FB, Yende S, Angus DC. Epidemiology of severe sepsis. Virulence. 2014 ;5(1):4-11.

Lin GL, McGinley JP, Drysdale SB, Pollard AJ. Epidemiology and Immune Pathogenesis of Viral Sepsis. Front Immunol. 2018;9:2147.

Suleyman G, Alangaden G, Bardossy AC. The Role of Environmental Contamination in the Transmission of Nosocomial Pathogens and Healthcare-Associated Infections. Curr Infect Dis Rep. 2018;20(6):12.

Polat G, Ugan RA, Cadirci E, Halici Z. Sepsis and Septic Shock: Current Treatment Strategies and New Approaches. Eurasian J Med. 2017;49(1):53-8.

Vijayan AL, Vanimaya, Ravindran S, Saikant R, Lakshmi S, Kartik R, et al. Procalcitonin: a promising diagnostic marker for sepsis and antibiotic therapy. J Intensive Care. 2017;5:51.

Ozbay S, Ayan M, Ozsoy O, Akman C, Karcioglu O. Diagnostic and Prognostic Roles of Procalcitonin and Other Tools in Community-Acquired Pneumonia: A Narrative Review. Diagnostics (Basel). 2023;13(11):1869.

Venet F, Monneret G. Advances in the understanding and treatment of sepsis-induced immunosuppression. Nat Rev Nephrol. 2018;14(2):121-37.

Jarczak D, Kluge S, Nierhaus A. Sepsis-Pathophysiology and Therapeutic Concepts. Front Med (Lausanne). 2021;8:628302.

Arora J, Mendelson AA, Fox-Robichaud A. Sepsis: network pathophysiology and implications for early diagnosis. Am J Physiol Regul Integr Comp Physiol. 2023;324(5):R613-24.

Poll T, Opal SM. Host-pathogen interactions in sepsis. Lancet Infect Dis. 2008;8(1):32-43.

Unar A, Bertolino L, Patauner F, Gallo R, Durante-Mangoni E. Pathophysiology of Disseminated Intravascular Coagulation in Sepsis: A Clinically Focused Overview. Cells. 2023;12(17):2120.

Kim WY, Hong SB. Sepsis and Acute Respiratory Distress Syndrome: Recent Update. Tuberc Respir Dis (Seoul). 2016;79(2):53-7.

Gyawali B, Ramakrishna K, Dhamoon AS. Sepsis: The evolution in definition, pathophysiology, and management. SAGE Open Med. 2019;7:2050312119835043.

Singer M, Deutschman CS, Seymour CW, Shankar-Hari M, Annane D, Bauer M, et al T, Vincent JL, Angus DC. The Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3). JAMA. 2016;315(8):801-10.

Bein T, Grasso S, Moerer O, Quintel M, Guerin C, Deja M, et al. The standard of care of patients with ARDS: ventilatory settings and rescue therapies for refractory hypoxemia. Intensive Care Med. 2016;42(5):699-711.

Getto L, Zeserson E, Breyer M. Vomiting, diarrhea, constipation, and gastroenteritis. Emerg Med Clin North Am. 2011;29(2):211-37.

Comstedt P, Storgaard M, Lassen AT. The Systemic Inflammatory Response Syndrome (SIRS) in acutely hospitalised medical patients: a cohort study. Scand J Trauma Resusc Emerg Med. 2009;17:67.

Faix JD. Biomarkers of sepsis. Crit Rev Clin Lab Sci. 2013;50(1):23-36.




How to Cite

Aljefri, A. A., Almutairi, L. H., Alraddadi, M. H., Alahmadi, S. A., Sufyani, A. Q., Almarzooq, J. N., Nashri, A. H. A., Al Wosaibi, F. A., Boukhamssein, N. A., Almahasnah, M. S., & Alyami, S. D. (2023). Definition, epidemiology and characterization of sepsis. International Journal Of Community Medicine And Public Health, 11(1), 376–380.



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