Uncommon Salmonella osteomyelitis in a previously healthy adult: a rare case report


  • Drishti Sagar Department of Laboratory Services, Aakash Healthcare Super Specialty Hospital, Delhi, India




Adults, Osteomyelitis, Salmonella typhi, Stewardship


Salmonella osteomyelitis (OM) is more common in individuals with hemoglobinopathies like sickle cell anemia or thalassemia. The cardinal symptoms of OM such as fever, pain, and soft tissue swelling do not point towards a specific etiological agent. Since a preceding history of gastrointestinal infections is usually absent it causes a diagnostic challenge for Salmonella OM which is often overlooked causing a delay in diagnosis. In cases of fluoroquinolone resistance, third generation cephalosporins become the drug of choice. Due to absence of standardized guidelines, management is usually on a case-to-case basis. Previous studies have been focused mostly on children. Here, we present a rare case of Salmonella typhi OM in a 25-year male without any common predisposing factors.


McAnearney S, McCall D. Salmonella osteomyelitis. Ulster Med J. 2015;84(3):171.

Arora A, Singh S, Aggarwal A, Aggarwal PK. Salmonella osteomyelitis in an otherwise healthy adult male—successful management with conservative treatment: a case report. J Orthop Surg. 2003;11(2):217-20.

Huang ZD, Wang CX, Shi TB, Wu BJ, Chen Y, Li WB, et al. Salmonella osteomyelitis in adults: a systematic review. Orthop Surg. 2021;13(4):1135-40.

Vynichakis G, Chandrinos M, Angelis S, Bogris E, Michelarakis JΝ. Salmonella Osteomyelitis of the Proximal Tibia in a Previously Healthy Adolescent: A Case Report. Cureus. 2019;11(9):e5672.

CLSI. Performance Standards for Antimicrobial Susceptibility Testing. 33rd edition. Wayne PA: CLSI supplement M100. 2023.

Fritz JM, McDonald JR. Osteomyelitis: approach to diagnosis and treatment. Phys Sportsmed. 2008;36(1):50-4.

Irshad M, Mahmood SF. Extended drug-resistant Salmonella typhi osteomyelitis: a case report and literature review. Egypt J Int Med. 2022;34(1):1-6.

Declercq J, Verhaegan J, Verbist L, Lammens J, Stuyck J, Fabry G. Salmonella typhi osteomyelitis. Arch Orthop Trauma Surg. 1994;113(4):232-4.

Ispahani P, Slack RC. Enteric fever and other extraintestinal salmonellosis in University Hospital, Nottingham, UK, between 1980 and 1997. Eur J Clin Microbiol Infect Dis. 2000;19(6):679-87.

Banky JP, Ostergaard L, Spelman D. Chronic relapsing salmonella osteomyelitis in an immunocomptent patient: case report literature review. J Infect. 2002:44(1):44-7.

Santos EM, Sapico FL. Vertebral osteomyelitis due to salmonellae: report of two cases and review. Clin Infect Dis. 1998;27(2):287-95.

Stephanie S, Schmalzle SA. Salmonella enterica serovar typhi osteomyelitis in a young adult with sickle cell and thalassemia traits: a possible association. ID Cases. 2019;15:e00478.

Saha SK, Talukder SY, Islam M, Saha S. A highly ceftriaxone-resistant Salmonella typhi in Bangladesh. Pediatr Infect Dis J. 1999;18(4):387.

Hassings RJ, Goessens WH, van Pelt W, Mevius DJ, Stricker BH, Molhoek N, et al. Salmonella subtypes with increased MICs for azithromycin in travelers returned to The Netherlands. Emerg Infect Dis. 2014;20(4):705-8.




How to Cite

Sagar, D. (2024). Uncommon Salmonella osteomyelitis in a previously healthy adult: a rare case report. International Journal Of Community Medicine And Public Health, 11(2), 963–966. https://doi.org/10.18203/2394-6040.ijcmph20240292



Case Reports