Exploring the impact of early-term labor induction on cesarean section risk in gestational diabetes mellitus: insights from a tertiary care hospital study in Pakistan
DOI:
https://doi.org/10.18203/2394-6040.ijcmph20240254Keywords:
Gestational diabetes mellitus, Labour, Outcome of pregnancy, Cesarean sectionAbstract
Background: Gestational diabetes mellitus (GDM) is the most common endocrine disorder in pregnancy. It is associated with significant perinatal morbidity and mortality, therefore, an early-term delivery by routine induction of labor is proposed by some societies, to prevent/reduce these complications.
Methods: This cross-sectional study was conducted between 1st January 2019 and 30th June 2020 at Aga Khan University Hospital, Pakistan to compare the pregnancy outcomes of patients with GDM when induced at 37, 38, and 39 weeks in comparison to women with GDM managed expectantly. The study included all women with singleton pregnancy and vertex presentation. Women induced after 41 weeks, previous cesarean delivery, placenta previa, major fetal anomalies, chronic maternal medical conditions that necessitate delivery, and those women presenting with spontaneous onset of labor were excluded. Data was analyzed in SPSS v.19.
Results: A total of 293 women were included. The mean age of women was 27 years, and the mean BMI was 27.8 kg/m2. We found that women who were induced at earlier gestational weeks were managed with a combination of diet and pharmacological therapy in comparison to those induced at later gestational weeks and achieved glycemic control with diet and lifestyle modifications only. Around 77% of women required pharmacological therapy. The mode of delivery was not significantly different for women induced at different gestational weeks after 37 completed weeks. For neonatal outcomes, the birth weight was significantly greater for women induced at later gestational weeks.
Conclusions: In women with gestational diabetes induced after 37 weeks at various gestational weeks, the mode of delivery is not significantly different.
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References
Sweeting A, Wong J, Murphy HR, Ross GP. A clinical update on gestational diabetes mellitus. Endocr Rev. 2022;43(5):763-93.
Federation ID. IDF diabetes atlas 8th edn. International diabetes federation. 2017:905-911.
Sheikh A, Sheikh L. Changing prevalence of gestational diabetes mellitus during pregnancy over more than a decade. Aga Khan University. 2020.
Choudhury AA, Rajeswari VD. Gestational diabetes mellitus- a metabolic and reproductive disorder. Biomed Pharmacother. 2021;143:112183.
Association AD. 14. Management of diabetes in pregnancy: standards of medical care in diabetes- 2020. Diabetes Care. 2020;43(Supplement_1):S183-92.
Gestational diabetes mellitus. Practice bulletin number 190. American College of Obstetricians and Gynecologists. Available from: https://www.acog.org/clinical/clinical-guidance/practice-bulletin/articles/2018/02/ gestational-diabetes-mellitus. Accessed on 28 August 2023.
Webber J, Charlton M, Johns N. Diabetes in pregnancy: management of diabetes and its complications from preconception to the postnatal period (NG3). Br J Diabetes. 2015;15(3):107-11.
Brown J. Screening, diagnosis and management of gestational diabetes in New Zealand A clinical practice guideline. University of Aukland. 2014.
Kalra B, Gupta Y, Kalra S. Timing of delivery in gestational diabetes mellitus: need for person-centered, shared decision-making. Diabetes Ther. 2016;7:169-74.
Yin Z, Li T, Zhou L, Fei J, Su J, Li D. Optimal delivery time for patients with diet-controlled gestational diabetes mellitus: a single-center real-world study. BMC Pregnancy Childbirth. 2022;22(1):356.
Li X, Li TT, Tian RX, Fei JJ, Wang XX, Yu HH, et al. Gestational diabetes mellitus: the optimal time of delivery. World J Diabetes. 2023;14(3):179.
Johns EC, Denison FC, Norman JE, Reynolds RM. Gestational diabetes mellitus: mechanisms, treatment, and complications. Trends Endocrinol Metab. 2018;29(11):743-54.
Remsberg KE, McKeown RE, McFarland KF, Irwin LS. Diabetes in pregnancy and cesarean delivery. Diabetes Care. 1999;22(9):1561-7.
Melamed N, Ray JG, Geary M, Bedard D, Yang C, Sprague A, et al. Induction of labor before 40 weeks is associated with lower rate of cesarean delivery in women with gestational diabetes mellitus. Am J Obstet Gynecol. 2016;214(3):364,e1-.e8.
Masood SN, Baqai S, Naheed F, Masood Y, Sikandar R, Chaudhri R, et al. Guidelines for management of hyperglycemia in pregnancy (HIP) by Society of Obstetricians and Gynaecologists of Pakistan (SOGP). J Diabetol. 2021;12(1):83-98.
Alberico S, Erenbourg A, Hod M, Yogev Y, Hadar E, Neri F, et al. Immediate delivery or expectant management in gestational diabetes at term: the GINEXMAL randomised controlled trial. BJOG. 2017;124(4):669-77.
Metzger BE, Lowe LP, Dyer AR, Trimble ER, Chaovarindr U, Coustan DR, et al. Hyperglycemia and adverse pregnancy outcomes. Obstet Anesth Digest. 2009;29(1):39-40.
Group HSCR. Hyperglycemia and Adverse Pregnancy Outcome (HAPO) Study: associations with neonatal anthropometrics. Diabetes. 2009;58(2):453-9.
Duran A, Sáenz S, Torrejón MJ, Bordiú E, Del Valle L, Galindo M, et al. Introduction of IADPSG criteria for the screening and diagnosis of gestational diabetes mellitus results in improved pregnancy outcomes at a lower cost in a large cohort of pregnant women: the St. Carlos gestational diabetes study. Diabetes care. 2014;37(9):2442-50.
Boriboonhirunsarn D, Waiyanikorn R. Emergency cesarean section rate between women with gestational diabetes and normal pregnant women. Taiwan J Obstet Gynecol. 2016;55(1):64-7.
Sermer M, Naylor CD, Farine D, Kenshole AB. The Toronto tri-hospital gestational diabetes project: a preliminary review. Diabetes care. 1998;21:B33.
Obstetricians ACo, Gynecologists. Weight gain during pregnancy. Committee opinion no. 548. Obstet Gynecol. 2013;121(1):210-2.
Pazzagli L, Abdi L, Kieler H, Cesta CE. Metformin versus insulin use for treatment of gestational diabetes and delivery by caesarean section: a nationwide Swedish cohort study. Eur J Obstet Gynecol Reprod Biol. 2020;254:271-6.
Inocêncio G, Braga A, Lima T, Vieira B, Zulmira R, Carinhas M, et al. Which factors influence the type of delivery and cesarean section rate in women with gestational diabetes? J Reprod Med. 2015;60(11-12):529-34.
Kjos S, Berkowitz K, Xiang A. Independent predictors of cesarean delivery in women with diabetes. J Matern Fet Neonat Med. 2004;15(1):61-7.
Bashir M, Aboulfotouh M, Dabbous Z, Mokhtar M, Siddique M, Wahba R, et al. Metformin-treated-GDM has lower risk of macrosomia compared to diet-treated GDM-a retrospective cohort study. J Matern Fet Neonat Med. 2020;33(14):2366-71.
Tabrizi R, Asemi Z, Lankarani KB, Akbari M, Khatibi SR, Naghibzadeh-Tahami A, et al. Gestational diabetes mellitus in association with macrosomia in Iran: a meta-analysis. J Diabetes Metab Disord. 2019;18:41-50.
Phaloprakarn C, Tangjitgamol S. Risk score for predicting primary cesarean delivery in women with gestational diabetes mellitus. BMC Pregnancy Childbirth. 2020;20:1-8.
Teixeira C, Lunet N, Rodrigues T, Barros H. The Bishop score as a determinant of labour induction success: a systematic review and meta-analysis. Arch Gynecol Obstet. 2012;286:739-53.