Effect of patient education and healthcare campaigns on medication adherence in co-morbid patients


  • Marwah Yakoop Abdullah Department of Family Medicine, East Jeddah Hospital, Jeddah, Saudi Arabia
  • Afrah Farhan Alanazi Almadinah Primary Healthcare Center, Health Defense Center for Public Health, Medina, Saudi Arabia
  • Abdulaziz Amin Alandijani Department of Pediatric Emergency, Al Aziziya Children Hospital, Jeddah, Saudi Arabia
  • Mazen Saleh Alshehri Pharmaceutical Care Department, Al Noor Specialist Hospital, Mecca, Saudi Arabia
  • Faris Saud Aljuaid Pharmaceutical Care Department, Al Noor Specialist Hospital, Mecca, Saudi Arabia
  • Noura Abdullah Bin Saab Pharmacy Department, AlQuwayiyah General Hospital, Al Quwayiyah, Saudi Arabia
  • Reem Ali Alshihri Primary Health Care, Ministry of Health, Jeddah, Saudi Arabia
  • Majed Hassan Ali Pharmacy Department, Security Forces Hospital, Riyadh, Saudi Arabia
  • Mohammed Abdullah Alghamdi College of Medicine, Albaha University, Al Baha, Saudi Arabia
  • Marwa Yusuf Hammad College of Medicine, Mansoura Manchester Programme for Medical Education, Mansoura, Egypt
  • Jameel Sami Althumali Department of Family Medicine, Taif Primary Health Care, Taif, Saudi Arabia




Medication, Adherence, Co-morbid conditions, Impact, Healthcare


Co-morbidities are characterized by the presence of multiple chronic diseases within a single individual. They pose an escalating healthcare challenge and managing this growing burden, particularly with non-communicable diseases, has become a major concern. However, a significant impediment to effective management lies in medication nonadherence. The importance of medication adherence has long been a focus of healthcare literature, yet many comorbid patients tend to underestimate its significance, leading to health deterioration. Research studies indicate alarmingly low adherence rates in comorbid patients. To address this issue, patient education and healthcare campaigns have become essential tools in enhancing adherence. The research, which commenced on October 19, 2023, was initiated after an exhaustive review of existing academic literature. Multiple databases, such as PubMed, Web of Science, and Cochrane, were employed for this comprehensive literature review, utilizing a wide array of medical terminology combinations. The study aims to shed light on potential strategies and educational approaches to enhance medication adherence in comorbid patients. Findings from this research have the potential to influence healthcare policy, the design of tailored interventions, and overall healthcare delivery improvements for co-morbid patients, ultimately leading to enhanced health outcomes, reduced costs, and an improved quality of life.



Valderas JM, Starfield B, Sibbald B, Salisbury C, Roland M. Defining comorbidity: implications for understanding health and health services. Ann Fam Med. 2009;7(4):357-63.

Sivaramakrishnan K, Parker RG. The United Nations High level meeting on the prevention and control of noncommunicable diseases: a missed opportunity? Am J Pub Heal. 2012;102(11):2010-12.

Marengoni A, Angleman S, Melis R, Francesca M, Anita K, Annika G et al. Aging with multimorbidity: a systematic review of the literature. Ageing Res Rev. 2011;10(4):430-9.

Wolff JL, Starfield B, Anderson G. Prevalence, expenditures, and complications of multiple chronic conditions in the elderly. Archives of internal medicine. 2002;162(20):2269-76.

Fortin M, Soubhi H, Hudon C, Bayliss EA, Van den Akker M. Multimorbidity's many challenges. Bri Med J. 2007;334:1016-7.

Ritchie C. Health care quality and multimorbidity: the jury is still out. LWW. 2007;45:477-9.

Rolnick SJ, Pawloski PA, Hedblom BD, Asche SE, Bruzek RJ. Patient characteristics associated with medication adherence. Clin Med Res. 2013;11(2):54-65.

Smaje A, Weston‐Clark M, Raj R, Orlu M, Davis D, Rawle M. Factors associated with medication adherence in older patients: A systematic review. Aging medicine. 2018;1(3):254-66.

Nice P. The most appropriate means of generic and specific interventions to support attitude and behaviour change at population and community levels. NICE DSU. 2007;2007(6).

Clarkesmith DE, Pattison HM, Khaing PH, Lane DA. Educational and behavioural interventions for anticoagulant therapy in patients with atrial fibrillation. Cochrane Database of Syst Rev. 2017(4).

Haynes R, Ackloo E, Sahota N, McDonald HP, Yao X. Interventions for enhancing medication adherence systematic review. Cochrane Database Syst Rev. 2008:(2):CD000011.

Nieuwlaat R, Wilczynski N, Navarro T. Interventions for enhancing medication adherence. Cochrane Database Syst Rev. 2014(11).

Glouberman S, Mintzberg H. Managing the care of health and the cure of disease—Part I: Differentiation. Health Care Management Rev. 2001:56-69.

Richard AA, Shea K. Delineation of self‐care and associated concepts. J Nursing Scholarship. 2011;43(3):255-64.

Lehane E, McCarthy G, Collender V, Deasy A, O’Sullivan K. The reasoning and regulating medication adherence instrument for patients with coronary artery disease: development and psychometric evaluation. J Nursing Measurem. 2013;21(1):64-79.

Shreck E, Gonzalez JS, Cohen HW, Walker EA. Risk perception and self-management in urban, diverse adults with type 2 diabetes: the improving diabetes outcomes study. International journal of behavioral medicine. 2014;21:88-98.

Schedlbauer A, Davies P, Fahey T. Interventions to improve adherence to lipid lowering medication. Cochrane Database Syst Rev. 2010.

Briesacher BA, Andrade SE, Fouayzi H, Chan KA. Comparison of Drug Adherence Rates Among Patients with Seven Different Medical Conditions. Pharmacotherapy: J Human Pharmacol Drug Therap. 2008;28(4):437-43.

Solomon DH, Avorn J, Katz JN, Joel SF, Marilyn A, Jennifer MP et al. Compliance with osteoporosis medications. Arch Intern Med. 2005;165(20):2414-9.

Brookhart MA, Patrick AR, Dormuth C, Jerry A, William S, Suzanne MC et al. Adherence to lipid-lowering therapy and the use of preventive health services: an investigation of the healthy user effect. Am J Epidemiol. 2007;166(3):348-54.

Ho PM, Rumsfeld JS, Masoudi FA, David LM, Mary EP, John FS et al. Effect of medication nonadherence on hospitalization and mortality among patients with diabetes mellitus. Arch Internal Med. 2006;166(17):1836-41.

Nau DP. Recommendations for improving adherence to type 2 diabetes mellitus therapy-focus on optimizing oral and non-insulin therapies. Am J Managed Care. 2012;18(3):S49.

Osterberg L, Blaschke T. Adherence to Medication. N Engl J Med. 2005;353(5):487-97.

Taibanguay N, Chaiamnuay S, Asavatanabodee P, Narongroeknawin P. Effect of patient education on medication adherence of patients with rheumatoid arthritis: a randomized controlled trial. Patient Preference Adherence. 2019:119-29.

Ayodapo A, Elegbede O, Omosanya O, Monsudi K. Patient education and medication adherence among hypertensives in a tertiary hospital, South Western Nigeria. Ethiop J Heal Sci. 2020;30(2).

Edworthy SM, Devins GM. Improving medication adherence through patient education distinguishing between appropriate and inappropriate utilization. Patient Education Study Group. J Rheumatol. 1999;26(8):1793-801.

Wilhelmsen NC, Eriksson T. Medication adherence interventions and outcomes: an overview of systematic reviews. Eur J Hospital Pharmacy. 2019;26(4):187-92.

Bosworth HB, Granger BB, Mendys P, Ralph B, Rebecca B, Susan MC et al. Medication adherence: A call for action. Am Heart J. 2011;162(3):412-24.




How to Cite

Abdullah, M. Y., Alanazi, A. F., Alandijani, A. A., Alshehri, M. S., Aljuaid, F. S., Saab, N. A. B., Alshihri, R. A., Ali, M. H., Alghamdi, M. A., Hammad, M. Y., & Althumali, J. S. (2023). Effect of patient education and healthcare campaigns on medication adherence in co-morbid patients. International Journal Of Community Medicine And Public Health, 10(12), 5009–5013. https://doi.org/10.18203/2394-6040.ijcmph20233807



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