Epidemiological investigation of congenital heart diseases among children during the years 2016 to 2021

Authors

  • Faramarz Ajri Khamesloo Department of Pediatrics, School of Medicine, Ardabil University of Medical Sciences, Ardabil, Iran
  • Mehrdad Mirzarahimi Department of Pediatrics, School of Medicine, Ardabil University of Medical Sciences, Ardabil, Iran
  • Firouz Amani Department of Community Medicine, School of Medicine, Ardabil University of Medical Sciences, Ardabil, Iran
  • Fatemeh Sadeghi Department of Medicine, School of Medicine, Ardabil University of Medical Sciences, Ardabil, Iran

DOI:

https://doi.org/10.18203/2394-6040.ijcmph20234115

Keywords:

Congenital heart disease, Diabetes, Newborns, Preterm, Prevalence

Abstract

Background: Congenital heart disease is a type of birth defect that affects about 1% of babies born each year and is the leading cause of death in infancy that is diagnosed at birth or later in life. Due to the high importance of this issue and high mortality and morbidity, the aim of this study was epidemiological investigation of congenital heart diseases in children during 2016 to 2021.

Methods: In this cross-sectional analytical study, all children admitted to Bo Ali Hospital in Ardabil with primary diagnosis of congenital heart disease or secondary diagnosis during hospitalization along with all children referred to the clinic of this hospital with diagnosis of congenital heart disease were included in the study.

Results: A total of 449 children with congenital heart disease were included in the study. 235 cases (52.33%) were boys, 35 cases (7.79%) had diabetic mothers and 12 cases (2.6%) had obese mothers. 20 cases (4.4%) were the result of multiple pregnancy and 31 cases (6.9%) were preterm. Significantly, preterm birth was more in children with cyanotic disease (p=0.036) and multiple births and maternal diabetes and aneuploidy were more in children with cyanotic disease compared to Asianotic children (p value equal to 0.008 respectively and 0.001 and 0.001).

Conclusions: The frequency of congenital heart diseases, gender composition and related risk factors such as preterm birth and maternal diabetes were aligned and similar to domestic and foreign studies. Maternal diabetes and preterm birth can be considered as risk factors for congenital heart diseases.

 

References

Mahler GJ, Butcher JT. Cardiac developmental toxicity. Birth Defects Research Part C: Embryo Today: Reviews. 2011;93(4):291-7.

Gilboa SM, Salemi JL, Nembhard WN, Fixler DE, Correa A. Mortality resulting from congenital heart disease among children and adults in the United States, 1999 to 2006. Circ. 2010;122(22):2254-63.

Richards A, Garg V. Genetics of congenital heart disease. Curr Cardiol Rev. 2010;6(2):91-7.

Bouma BJ, Mulder BJ. Changing landscape of congenital heart disease. Circ. 2017;120(6):908-22.

Jin SC, Homsy J, Zaidi S, Lu Q, Morton S, DePalma SR, et al. Contribution of rare inherited and de novo variants in 2,871 congenital heart disease probands. Nature Genetic. 2017;49(11):1593-601.

Botto LD, Lin AE, Riehle‐Colarusso T, Malik S, Correa A. Seeking causes: classifying and evaluating congenital heart defects in etiologic studies. Clin Mol Teratol. 2007;79(10):714-27.

Liu Y, Chen S, Zühlke L, Black GC, Choy M-k, Li N, et al. Global birth prevalence of congenital heart defects 1970–2017: updated systematic review and meta-analysis of 260 studies. Int J Epidemiol. 2019;48(2):455-63.

Cardiology EbtAfEP, Members ATF, Baumgartner H, Bonhoeffer P, De Groot NM, de Haan F, et al. ESC Guidelines for the management of grown-up congenital heart disease (new version 2010) The Task Force on the Management of Grown-up Congenital Heart Disease of the European Society of Cardiology (ESC). Eur Heart J. 2010;31(23):2915-57.

Crystal MA, Ing FF. Pediatric interventional cardiology: 2009. Curr Opin Pediatr. 2010;22(5):567-72.

Derakhshan R, Raeisi N, Sadeghi T. Prevalence of congenital heart disease and related factors among children admitted to the pediatric cardiac center in Rafsanjan, Southeastern Iran. Novelty Clin Med. 2022;1(3):121-6.

Mohsenzadeh A, Saket S, Ahmadipour S, Baharvand B. Prevalence and types of congenital heart disease in babies born in the city of Khorramabad (2007-2011). Yafte. 2014;15(5):23-9.

Zhao QM, Liu F, Wu L, Ma XJ, Niu C, Huang GY. Prevalence of congenital heart disease at live birth in China. J Pediatr. 2019;204:53-8.

Mat Bah MN, Sapian MH, Jamil MT, Abdullah N, Alias EY, Zahari N. The birth prevalence, severity, and temporal trends of congenital heart disease in the middle‐income country: a population‐based study. Congenit Heart Dis. 2018;13(6):1012-27.

Leirgul E, Fomina T, Brodwall K, Greve G, Holmstrøm H, Vollset SE, et al. Birth prevalence of congenital heart defects in Norway 1994-2009-A nationwide study. Am Heart J. 2014;168(6):956-64.

Yusuf MF, Icen YK, Ahmed SA, Osman AA, Hussein AM. Frequency and pattern of congenital heart diseases among children in a Tertiary Hospital in Mogadishu, Somali, 2019: a hospital-based study. Iran Heart J. 2021;22(1):10-5.

Mills JL, Troendle J, Conley MR, Carter T, Druschel CM. Maternal obesity and congenital heart defects: a population-based study. Am J Clin Nutrit. 2010;91(6):1543-9.

Chen L, Yang T, Chen L, Wang L, Wang T, Zhao L, et al. Risk of congenital heart defects in offspring exposed to maternal diabetes mellitus: an updated systematic review and meta-analysis. Arch Gynecol Obstetr. 2019;300(6):1491-506.

Richards AA, Santos LJ, Nichols HA, Crider BP, Elder FF, Hauser NS, et al. Cryptic chromosomal abnormalities identified in children with congenital heart disease. Pediatr Res. 2008;64(4):358-63.

Hoffman JI, Christianson R. Congenital heart disease in a cohort of 19,502 births with long-term follow-up. Am J Cardiol. 1978;42(4):641-7.

Sun R, Liu M, Lu L, Zheng Y, Zhang P. Congenital heart disease: causes, diagnosis, symptoms, and treatments. Cell Biochem Biophy. 2015;72(3):857-60.

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Published

2023-12-30

How to Cite

Khamesloo, F. A., Mirzarahimi, M., Amani, F., & Sadeghi, F. (2023). Epidemiological investigation of congenital heart diseases among children during the years 2016 to 2021. International Journal Of Community Medicine And Public Health, 11(1), 111–115. https://doi.org/10.18203/2394-6040.ijcmph20234115

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Original Research Articles