Dental stem cells and their applications in pediatric dentistry
DOI:
https://doi.org/10.18203/2394-6040.ijcmph20233550Keywords:
Dental stem cells, Regenerative medicine, Pediatric dentistry, Stem cell regenerationAbstract
Regenerative medicine has garnered significant attention due to its transformative impact on disease management and the restoration of optimal bodily functions. Stem cells, a cornerstone of regenerative medicine, are particularly renowned for their remarkable capacity to facilitate tissue regeneration and repair, revolutionizing modern healthcare by offering diverse treatment avenues for multiple conditions. Dental pulp stem cells (DPSCs), a subset of postnatal stem cells, are especially noteworthy for their extensive proliferation and ability to differentiate into various specialized cell types. In the realm of pediatric dentistry, there exists a pressing need for advancements in regenerative medicine. Thorough research in this domain has the potential to propel evidence-based pediatric dentistry, ensuring that children receive tailored, high-quality care. Stem cells hold immense promise in pediatric dentistry by offering less invasive and regenerative solutions for a range of childhood dental issues and congenital anomalies. This research, initiated on 04 October 2023, was instigated following an exhaustive review of existing literature utilizing databases like PubMed, Web of Science, and Cochrane. The literature search encompassed a wide array of medical terminologies. Dental stem cells are categorized into four major types: DPSCs, stem cells from human exfoliated deciduous teeth (SHED), stem cells of the apical papilla (SCAP), and periodontal ligament stem cells (PDLSCs). Pediatric dentistry, encompassing endodontics, orthodontics, periodontics, and the treatment of craniofacial defects, stands to benefit significantly from the potential of dental stem cells. The preservation of dental pulp stem cells extracted from deciduous and permanent teeth through tooth banking offers a source for future regenerative therapies. The preservation process involves multiple comprehensive steps. In summary, dental stem cells present a promising avenue within pediatric dentistry, offering multifaceted applications ranging from pulpal regeneration and dentin repair to orthodontic support and the treatment of craniofacial anomalies.
References
Clinic M. About regenerative medicine. 2023. Available at: mayo.edu/research/centers-programs/ center-regenerative-biotherapeutics/about/about-regenerative-medicine. Accessed on 24 September 2023.
Yang B, Qiu Y, Zhou N, Ouyang H, Ding J, Cheng B, Sun J. Application of Stem Cells in Oral Disease Therapy: Progresses and Perspectives. Front Physiol. 2017;8:197.
Chopra H, Hans MK, Shetty S. Stem cells-the hidden treasure: A strategic review. Dent Res J. 2013;10(4):421.
Tammannavar P. Dental pulp stem cells scope in dentistry: A review. IOSR J Dent Med Sci. 2013;8:38-41.
Sloan AJ, Waddington RJ. Dental pulp stem cells: what, where, how? Int J Paediatric Dentistry. 2009;19(1):61-70.
Iglesias-Linares A, Yáñez-Vico R-M, Sánchez-Borrego E, Moreno-Fernández AM, Solano-Reina E, Mendoza-Mendoza A. Stem cells in current paediatric dentistry practice. Arch Oral Biol. 2013;58(3):227-38.
Popuri SK. Concerns of a pediatric dentist in dental stem cells: an overview. Open Dentistry J. 2018;12:596.
Petrovic V, Stefanovic V. Dental Tissue — New Source for Stem Cells. Scientific World J. 2009;9:849637.
Chang J, Zhang C, Tani-Ishii N, Shi S, Wang C-Y. NF-κB activation in human dental pulp stem cells by TNF and LPS. J Dent Res. 2005;84(11):994-8.
Pattanaik S, Govind S, Mishra L, Jena D, Jena SP. Role of Stem Cells in Dentistry: A Review. Indian J Forensic Med Toxicol. 2020;14(4):8448-55.
Nadig RR. Stem cell therapy–Hype or hope? A review. J Conserv Dent. 2009;12(4):131.
Dali M, Rajbanshi L. Regenerative endodontics: changes, chances, and challenges of revascularization in pediatric dentistry. SRM J Res Dent Sci. 2014;5(3):186-9.
Gay IC, Chen S, MacDougall M. Isolation and characterization of multipotent human periodontal ligament stem cells. Orthodont Craniofac Res. 2007;10(3):149-60.
Arora V, Arora P, Munshi A. Banking stem cells from human exfoliated deciduous teeth (SHED): saving for the future. J Clin Pediatric Dentistry. 2009;33(4):289-94.
Zhang W, Walboomers XF, Shi S, Fan M, Jansen JA. Multilineage differentiation potential of stem cells derived from human dental pulp after cryopreservation. Tissue Engineer. 2006;12(10):2813-23.
Safari S, Mahdian A, Motamedian SR. Applications of stem cells in orthodontics and dentofacial orthopedics: Current trends and future perspectives. World J Stem Cells. 2018;10(6):66.
Weltman B, Vig KW, Fields HW, Shanker S, Kaizar EE. Root resorption associated with orthodontic tooth movement: a systematic review. Am J Orthodont Dentofac Orthop. 2010;137(4):462-76.
Risbud M, Shapiro I. Stem cells in craniofacial and dental tissue engineering. Orthodont Craniofac Res. 2005;8(2):54-9.
Sanchez-Lara PA, Zhao H, Bajpai R, Abdelhamid AI, Warburton D. Impact of stem cells in craniofacial regenerative medicine. Front Physiol. 2012;3:188.
Huang Y-H, Yang J-C, Wang C-W, Lee S-Y. Dental Stem Cells and Tooth Banking for Regenerative Medicine. J Exp Clin Med. 2010;2(3):111-7.
Hegde MN, Hegde P, D’Souza CM. Tooth stem cell banking-A review. Conserv Endodont Soc Kerala. 2012;45:423-8.
Chen Y, Wang X, Wu Z, Jia S, Wan M. Epigenetic regulation of dental-derived stem cells and their application in pulp and periodontal regeneration. Peer J. 2023;11:e14550.
Zeitlin BD. Banking on teeth - Stem cells and the dental office. Biomed J. 2020;43(2):124-33.
