Types, accuracy, and efficacy of salivary biomarkers in periodontal diagnosis

Authors

  • Maha A. Munshi Department of Periodontics, Al Thager Hospital, Jeddah, Saudi Arabia
  • Hanan A. Almozher Department of Periodontics, King Salman Hospital, Riyadh, Saudi Arabia
  • Fatimah A. Alqahtani Al-Baha Primary Healthcare Centers, Al Baha, Saudi Arabia
  • Mohamed M. Youssef King Abdulaziz University Dental Hospital, Jeddah, Saudi Arabia
  • Abeer S. Almtere North Jeddah Specialized Dental Center, Jeddah, Saudi Arabia
  • Basel K. Alsadoon Barad Clinical Center, Hail, Saudi Arabia
  • Lubna S. Alotheem Ministry of Health, Al Qassim, Saudi Arabia
  • Lama F. Alhowirini King Abdulaziz University, Jeddah, Saudi Arabia
  • Abdullah M. Alotaibi General Administration of Medical Services in Public Security, Security Forces Specialized Comprehensive Polyclinics, Riyadh, Saudi Arabia
  • Abdullah A. Almutairi College of Dentistry, King Saud bin Abdulaziz University for Health Sciences, Riyadh, Saudi Arabia
  • Ali H. Assiri Ministry of Health, Al-Jumum, Saudi Arabia

DOI:

https://doi.org/10.18203/2394-6040.ijcmph20233523

Keywords:

Accuracy, Biomarkers, Diagnosis, Efficacy, Periodontal disease

Abstract

Periodontal diseases primarily occur due, to infections and inflammation that affect the gums and bone structures supporting the teeth. In the stage, known as gingivitis the gums may become swollen turn red and bleed easily. These health issues not impact health but also have broader implications for overall well-being, including tooth loss, discomfort, bad breath and an increased vulnerability, to chronic illnesses. The main objective of this review is to examine aspects pertaining to diseases encompassing clinical indications, methods, for diagnosis, available treatment choices, and preventive strategies. This research meticulously examines the types of these diseases, their stages, and their causes. It also discusses the approaches and criteria used to diagnose these conditions. Additionally, the paper provides an evaluation of treatment alternatives and strategic frameworks, for managing pathologies. This includes both surgical approaches, well as supportive therapies. The paper emphasizes the importance of measures. Maintaining oral health through consistent dental hygiene practices, regular dental checkups, and necessary lifestyle adjustments. In conclusion, while periodontal diseases pose challenges in practice they can be controlled and prevented through collaboration, between dental practitioners, dental hygienists, and active patient participation.

 

References

Zhang Y, Kang N, Xue F, Qiao J, Duan J, Chen F, et al. Evaluation of salivary biomarkers for the diagnosis of periodontitis. BMC Oral Health. 2021;21(1):266.

Corbet E, Ho D, Lai S. Radiographs in periodontal disease diagnosis and management. Australian Dental J. 2009;54(s1):S27-43.

Assiri H, Dawasaz AA, Alahmari A, Asiri Z. Cone beam computed tomography (CBCT) in periodontal diseases: a Systematic review based on the efficacy model. BMC Oral Health. 2020;20(1):191.

Pfaffe T, Cooper-White J, Beyerlein P, Kostner K, Punyadeera C. Diagnostic Potential of Saliva: Current State and Future Applications. Clin Chem. 2011;57(5):675-87.

Sindhu S, Jagannathan N. Saliva: A Cutting Edge in Diagnostic Procedures. J Oral Dis. 2014;168584.

Arora A, Kaur D, Patiyal S, Kaur D, Tomer R, Raghava GPS. SalivaDB—a comprehensive database for salivary biomarkers in humans. Database. 2023;2023.

Al-Rawi NH, Al-Marzooq F, Al-Nuaimi AS, Hachim MY, Hamoudi R. Salivary microRNA 155, 146a/b and 203: A pilot study for potentially non-invasive diagnostic biomarkers of periodontitis and diabetes mellitus. Plos One. 2020;15(8):e0237004.

Cerón JJ. Acute phase proteins, saliva and education in laboratory science: an update and some reflections. BMC Vet Res. 2019;15(1):197.

Ryznar R, Wong C, Onat E, Towne F, LaPorta A, Payton M. Principal component analysis of salivary cytokines and hormones in the acute stress response. Front Psychiatry. 2022;13.

Yoshizawa JM, Schafer CA, Schafer JJ, Farrell JJ, Paster BJ, Wong DT. Salivary biomarkers: toward future clinical and diagnostic utilities. Clin Microbiol Rev. 2013;26(4):781-91.

Löfgren CD, Wickström C, Sonesson M, Lagunas PT, Christersson C. A systematic review of methods to diagnose oral dryness and salivary gland function. BMC Oral Health. 2012;12:29.

Reddahi S, Bouziane A, Rida S, Tligui H, Ennibi O. Salivary Biomarkers in Periodontitis Patients: A Pilot Study. Int J Dentistry. 2022;3664516.

Shukla H, Mason JL, Sabyah A. Identifying genetic markers associated with susceptibility to cardiovascular diseases. Future Sci OA. 2019;5(1):Fso350.

Mohammed HA, Abdulkareem AA, Zardawi FM, Gul SS. Determination of the Accuracy of Salivary Biomarkers for Periodontal Diagnosis. Diagnostics (Basel). 2022;12(10).

Hirai K, Yamaguchi-Tomikawa T, Eguchi T, Maeda H, Takashiba S. Identification and Modification of Porphyromonas gingivalis Cysteine Protease, Gingipain, Ideal for Screening Periodontitis. Front Immunol. 2020;11.

Gul SS, Abdulkareem AA, Sha AM, Rawlinson A. Diagnostic Accuracy of Oral Fluids Biomarker Profile to Determine the Current and Future Status of Periodontal and Peri-Implant Diseases. Diagnostics (Basel). 2020;10(10).

Fan W, Liu C, Zhang Y, Yang Z, Li J, Huang S. Epidemiology and associated factors of gingivitis in adolescents in Guangdong Province, Southern China: a cross-sectional study. BMC Oral Health. 2021;21(1):311.

Könönen E, Gursoy M, Gursoy UK. Periodontitis: A Multifaceted Disease of Tooth-Supporting Tissues. J Clin Med. 2019;8(8).

Lim G, Janu U, Chiou L-L, Gandhi KK, Palomo L, John V. Periodontal Health and Systemic Conditions. Dentistry J. 2020;8(4):130.

Tariq M, Iqbal Z, Ali J, Baboota S, Talegaonkar S, Ahmad Z, et al. Treatment modalities and evaluation models for periodontitis. Int J Pharm Investig. 2012;2(3):106-22.

Darby I. Non-surgical management of periodontal disease. Aust Dent J. 2009;54(s1):S86-95.

Salvi GE, Stähli A, Schmidt JC, Ramseier CA, Sculean A, Walter C. Adjunctive laser or antimicrobial photodynamic therapy to non-surgical mechanical instrumentation in patients with untreated periodontitis: A systematic review and meta-analysis. J Clin Periodontol. 2020;47(S22):176-98.

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Published

2023-11-08

How to Cite

Munshi, M. A., Almozher, H. A., Alqahtani, F. A., Youssef, M. M., Almtere, A. S., Alsadoon, B. K., Alotheem, L. S., Alhowirini, L. F., Alotaibi, A. M., Almutairi, A. A., & Assiri, A. H. (2023). Types, accuracy, and efficacy of salivary biomarkers in periodontal diagnosis. International Journal Of Community Medicine And Public Health, 10(12), 4988–4992. https://doi.org/10.18203/2394-6040.ijcmph20233523

Issue

Section

Review Articles