Prevalence of SARS-CoV-2 infection in asymptomatic preoperative patients

Authors

  • Gul Bayram Vocational School of Health Services, Mersin University, Mersin, Turkiye
  • Harun Gulbudak Department of Biology, Faculty of Science, Mersin University, Mersin, Turkiye
  • Taylan Bozok Department of Medical Microbiology, Faculty of Medicine, Mersin University, Mersin, Turkiye
  • Gonul Aslan Department of Medical Microbiology, Faculty of Medicine, Mersin University, Mersin, Turkiye

DOI:

https://doi.org/10.18203/2394-6040.ijcmph20233148

Keywords:

SARS-CoV-2, Preoperative, Asymptomatic, Thoracic surgery

Abstract

Background: Surgeries were performed on emergency and trauma patients as well as oncology patients in many centres during the pandemic period. Screening of asymptomatic preoperative patients is very important not only in protecting healthcare personnel but also in preventing nosocomial infections and in protecting patients with deficient or suppressed immune systems. The aim of the current study was to retrospectively evaluate the prevalence of SARS-CoV-2 infection in asymptomatic preoperative patients during the pandemic period.

Methods: A total of 3773 asymptomatic preoperative patients among the 23385 patients were evaluated retrospectively with Rt-qPCR test. The DS CORONEX COVID-19 PCR test (Ver.2.0, DS Bio and nano technology, Turkiye) kit used for the RT-qPCR. PCR test targets the N and Orf1ab gene region specific for SARS-CoV-2.

Results: SARS-CoV-2 positivity was significantly lower in the preoperative patient group than in COVID-19 positive patients whose routine test results were positive for other reasons (2.3% vs 23.1%; p<0.0005). Distribution of preoperative SARS-CoV-2 positive patients according to clinics were 7.1% thoracic surgery, 3.7% neurosurgery, 3.5% otolaryngology, 2.6% general surgery and 2.4% urology clinic, respectively.

Conclusions: SARS-CoV-2 positivity was lower in the preoperative patients but this rate never excludes pre-screening of asymptomatic preoperative patients. Applying pre-screening tests to asymptomatic preoperative patients is significant in protecting healthcare personnel and patients with deficient or suppressed immune systems and also preventing nosocomial infections.

References

World Health Organization. Available at: https://covid19.who.int. Accessed on 10 August 2023.

T.R. Ministry of Health General Directorate of Public Health. Covid-19 (SARS-CoV-2 Infection) Guide. Scientific Committee Study. 16 March 2020. Available at: https://covid19rehberi.com/t-c-saglik-bakanligi-saglik-kurumlarina-yonelik-alinacak-uygulamalarin-belirlenmesi-16-03-2020-20-03-2020-23-03-2020. Accessed on 10 August 2023.

Yasmin F, Bin Zafar MD, Salman A, Farooque U, Asghar MS, Khan AA, et al. Exploring the impact of the COVID-19 pandemic on pediatric surgical services. Minerva Pediatr (Torino). 2021;73(5):460-6.

Al-Khersan H, Kalavar MA, Tanenbaum R, Lazzarini TA, Patel NA, Yannuzzi NA, et al. Emergent Ophthalmic Surgical Care at a Tertiary Referral Center During the COVID-19 Pandemic. Am J Ophthalmol. 2021;222:368-372.

Pujol R, Rivas E, Gracia I, Caballero A, Matute P, Cuñat T, et al. Preoperative triage to detect SARS-CoV-2 infection in surgical patients: lessons learned for resuming surgery. Surg Today. 2023;53(6):709-17.

Lippi G, Sanchis-Gomar F, Henry BM. Negative preoperative RT-PCR screening is no guaranty of no SARS-CoV-2 infection. Rev Esp Anestesiol Reanim (Engl Ed). 2023;70(2):119-20.

Duś-Ilnicka I, Szymczak A, Małodobra-Mazur M, Tokarski M. Role of Laboratory Medicine in SARS-CoV-2 Diagnostics. Lessons Learned from a Pandemic. Healthcare (Basel). 2021;9(7):915.

Randriamahazo TR, Andrianarivelo AM, Rakotoarivo AT, Raheritiana TM, Rakotovao LA, Randriamanantany ZA, et al. Evaluation of antigen-based rapid detection test for the diagnosis of SARS CoV-2 in low-income countries. J Virol Methods. 2022;300:114409.

Puylaert CAJ, Scheijmans JCG, Borgstein ABJ, Andeweg CS, Bartels-Rutten A, Beets GL, et al. Yield of Screening for COVID-19 in Asymptomatic Patients Before Elective or Emergency Surgery Using Chest CT and RT-PCR (SCOUT): Multicenter Study. Ann Surg. 2020;272(6):919-24.

World health Organization. Laboratory testing for 2019 novel coronavirus (2019-nCoV) in suspected human cases. Available at: https://www.who.int/ publications/i/item/10665-331501. Accessed on 22 August 2023.

Fiorelli S, Menna C, Piccioni F, Zuanetti G, Valenza F, Rispoli M, et al. Preoperative SARS-CoV-2 Infection Screening before Thoracic Surgery during COVID-19 Pandemic: A Multicenter Retrospective Study. Int J Clin Pract. 2023;2023:8993295.

Ota I, Asada Y. The impact of preoperative screening system on head and neck cancer surgery during the COVID-19 pandemic: Recommendations from the nationwide survey in Japan. Auris Nasus Larynx. 2020;47(4):687-91.

Arslanoğlu E, Işık ME, Kara KA, Yigit F, Çine N, Tunçer E, et al. Preoperative monocytosis is predictable at diagnosis for RT-PCR negative COVİD-19 paediatric cardiac surgery patients. Cardiol Young. 2022;32(6):883-7.

Aminian A, Safari S, Razeghian-Jahromi A, Ghorbani M, Delaney CP. COVID-19 Outbreak and Surgical Practice: Unexpected Fatality in Perioperative Period. Ann Surg. 2020;272(1):e27-9.

COVID Surg Collaborative. Elective surgery cancellations due to the COVID-19 pandemic: global predictive modelling to inform surgical recovery plans. Br J Surg. 2020;107(11):1440-49.

Albendín-Iglesias H, Mira-Bleda E, Roura-Piloto AE, Hernández-Torres A, Moral-Escudero E, Fuente-Mora C, et al. Usefulness of the epidemiological survey and RT-PCR test in pre-surgical patients for assessing the risk of COVID-19. J Hosp Infect. 2020;105(4):773-5.

Shoff HW, Huecker M, Davis H, Smith JW. Very Low Rate of Positive COVID Infections (<0.5%) on Preoperative Screening in the Elective Procedure Population. Am Surg. 2023;89(4):1216-7.

Colas AE, Azale M, Ayanmanesh F, Tran C, Papapanayotou L, Assaker R, et al. Mandatory preoperative SARS-CoV-2 infection screening policies for paediatric surgery. Br J Anaesth. 2021;126(5):e182-4.

Lin EE, Blumberg TJ, Adler AC, Fazal FZ, Talwar D, Ellingsen K, et al. Incidence of COVID-19 in Pediatric Surgical Patients Among 3 US Children’s Hospitals. JAMA Surg. 2020;155(8):775-7.

Souza CDS, Saruhashi T, Lima MFN, Oliveira Junior FI, Cumino DO. A retrospective report on the preoperative mandatory SARS-COV-2 infection screening in a single pediatric center. Is it time to stop testing our patients? Rev Col Bras Cir. 2023;49:e20223433.

De Bock E, Filipe MD, Simmermacher RKJ, Kroese AC, Vriens MR, Richir MC. Meta-analysis of COVID-19 prevalence during preoperative COVID-19 screening in asymptomatic patients. BMJ Open. 2022;12(7):e058389.

Samiul Islam M, Parvin S, Mahbubur Rahman Khan M, Hossain GMJ, Zahiruddin AKM, Alam MJ, et al. Asymptomatic RT-PCR positive COVID-19 patients in orthopaedic pre-operative evaluation during the peak of the second wave. Clin Infect Pract. 2022;13:100131.

Muhammad RC, Bisiriyu OE. Prevalence of COVID-19 Infection Among Asymptomatic Ophthalmic Surgical Patients Undergoing Ophthalmic Procedures at University of Abuja Teaching Hospital, Gwagwalada, Abuja. J West Afr Coll Surg. 2021;11(2):14-8.

Hou J, Wan X, Shen Q, Zhu J, Leng Y, Zhao B, et al. COVID-19 infection, a potential threat to surgical patients and staff? A retrospective cohort study. Int J Surg. 2020;82:172-8.

Liang W, Guan W, Chen R, Wang W, Li J, Xu K, et al. Cancer patients in SARS-CoV-2 infection: a nationwide analysis in China. Lancet Oncol. 2020;21(3):335-7.

Downloads

Published

2023-10-06

How to Cite

Bayram, G., Gulbudak, H., Bozok, T., & Aslan, G. (2023). Prevalence of SARS-CoV-2 infection in asymptomatic preoperative patients. International Journal Of Community Medicine And Public Health, 10(11), 3979–3983. https://doi.org/10.18203/2394-6040.ijcmph20233148

Issue

Section

Original Research Articles