A descriptive comparative study on COVID-19 impact among people living with human immunodeficiency virus at tertiary care hospital: Bengaluru urban
Keywords:PLHIV, Adherence, COVID-19, Impact, ART
Introduction: The SARS-CoV-2 virus is the infectious disease known as coronavirus disease (COVID-19). A lockdown was implemented across the nation in response to escalating infections and community transmission. Patients Living with Human Immunodeficiency Virus (PLHIV) must get therapy for the rest of their lives. Anti-Retroviral Therapy (ART) must be available and strictly adhered to in order to lower HIV-related morbidity and mortality and stop HIV transmission. ART continuity in PLHIV has been compromised globally by the COVID-19 epidemic. This research was done to find out how the pandemic affected PLHIV patient’s adherence to their ART regimens.
Methods: For nine months, PLHIV visiting the ART centre in a tertiary care hospital in Bengaluru urban participated in this a prospective comparative study. Through systematic random sampling, 470 patients were chosen for the study. Data were gathered by one-on-one interviews using a standardised semi-structured questionnaire. The statistics used were mean, median, and z test for proportion.
Results: The bulk of the study participants were male and between the ages of 41 and 50. The most frequent means of HIV transmission risk was heterosexual interaction. Before and during the COVID-19 pandemic, there was a large difference in the number of PLHIV/day visits. Opportunistic infections and first-line failures were more common and statistically significant during the COVID-19 pandemic. Prior to the pandemic, there was an average 94.84% adherence to ART, which dropped to 80.55% during the pandemic. The variation was substantial.
Conclusion: The COVID-19 pandemic has impacted PLHIV medication adherence, and opportunistic infections have increased during this time.
Coronavirus. Available at: https://www.who.int/ health-topics/coronavirus#tab=tab_1. Accessed on 30 January 2023.
Mirzaei H, McFarland W, Karamouzian M, Sharifi H. COVID-19 Among People Living with HIV: A Systematic Review. AIDS Behav. 2021;25(1):85-92.
Weerasuria M, Ko C, Ehm A, O’bryan J, Mcmahon J, Woolley I, et al. The Impact of the COVID-19 Pandemic on People Living with HIV in Victoria, Australia. AIDS Res Hum Retroviruses. 2021;37(4):322-8
Sun Y, Zhan Y, Li H, Yuan T, Gao Y, Liang B, et al. Stakeholder efforts to mitigate antiretroviral therapy interruption among people living with HIV during the COVID-19 pandemic in China: a qualitative study. J Int AIDS Soc. 2021;24:25781.
Sun Y, Li H, Luo G, Meng X, Guo W, Fitzpatrick T, et al. Antiretroviral treatment interruption among people living with HIV during COVID-19 outbreak in China: a nationwide cross-sectional study. J Int AIDS Soc. 2020;23(11):e25637.
Lee D, Chow EPF, Aguirre I, Fairley CK, Ong JJ, Lee D, et al. Access to HIV Antiretroviral Therapy among People Living with HIV in Melbourne during the COVID-19 Pandemic. Pandemic Int J Environ Res Public Heal. 2021;18:12765.
Rodriguez A, Carballo N, Río-No L, Perez C, González-Colominas E, Monfort J, et al. Non-adherence in rheumatological immune mediated diseases. Eur J Hosp Pharm. 2021;28(1):2021.
Wagner Z, Mukasa B, Nakakande J, Stecher C, Saya U, Linnemayr S. Impact of the COVID-19 Pandemic on Use of HIV Care, Antiretroviral Therapy Adherence, and Viral Suppression: An Observational Cohort Study From Uganda. J Acquir Immune Defic Syndr. 2021;88(5):448-56.
Boulle A, Davies MA, Hussey H, Ismail M, Morden E, Vundle Z, et al. Risk Factors for Coronavirus Disease 2019 (COVID-19) Death in a Population Cohort Study from the Western Cape Province, South Africa. Clin Infect Dis. 2021;73(7):E2005-15.
Nyogea D, Mtenga S, Henning L, Franzeck FC, Glass TR, Letang E, et al. Determinants of antiretroviral adherence among HIV positive children and teenagers in rural Tanzania: A mixed methods study. BMC Infect Dis. 2015;15(1):1-13.
Zewude SB, Ajebe TM. Magnitude of optimal adherence and predictors for a low level of adherence among HIV/AIDS-infected adults in South Gondar zone, Northwest Ethiopia: a multifacility cross-sectional study. BMJ Open. 2022;12(1):1-7.
Campbell LS, Masquillier C, Knight L, Delport A, Sematlane N, Dube LT, et al. Stay-at-Home: The Impact of the COVID-19 Lockdown on Household Functioning and ART Adherence for People Living with HIV in Three Sub-districts of Cape Town, South Africa. AIDS Behav. 2022;26(6):1905-22.
Ray I, Hasan MM, Shah PA, Sahito AM, Sarkar A, Ghosh D, et al. HIV epidemic amidst COVID-19 pandemic in India: A conundrum for the country’s healthcare system. Epidemiol Infect. 2022;150:19-21.
Rick F, Odoke W, van den Hombergh J, Benzaken AS, Avelino-Silva VI. Impact of coronavirus disease (COVID-19) on HIV testing and care provision across four continents. HIV Med. 2022;23(2):169-77.
Prevailing against pandemics by putting people at the centre-World AIDS Day report 2020 | UNAIDS. Available at: https://www.unaids.org/en/resources/ documents/2020/prevailing-against-pandemics. Accessed on 10 April 2023.
Van Staden Q, Laurenzi CA, Toska E. Two years after lockdown: reviewing the effects of COVID-19 on health services and support for adolescents living with HIV in South Africa. J Int AIDS Soc. 2022;25(4):1-6.
Kumar S. AIDS and COVID-19 infections: impact on vulnerable Indian population. New Microbes New Infect. 2021;42:100903.
Hung CC, Banerjee S, Gilada I, Green K, Inoue Y, Kamarulzaman A, et al. Impact of COVID-19 on the HIV care continuum in Asia: Insights from people living with HIV, key populations, and HIV healthcare providers. PLoS One. 2022;17(7):1-18.
Pollard R, Gopinath U, Reddy YA, Kumar BR, Mugundu P, Vasudevan CK, et al. HIV service delivery in the time of COVID-19: focus group discussions with key populations in India. J Int AIDS Soc. 2021;24(S6):59-66.