India’s sustaining challenges to combat rabies elimination: a comprehensive review

Authors

  • Arun Krishna S. R. Department of Epidemiology, The Tamil Nadu Dr. MGR Medical University, Chennai, Tamil Nadu, India
  • Hemapriya A. S. Department of Epidemiology, The Tamil Nadu Dr. MGR Medical University, Chennai, Tamil Nadu, India
  • Jasmine S. Sundar Department of Epidemiology, The Tamil Nadu Dr. MGR Medical University, Chennai, Tamil Nadu, India

DOI:

https://doi.org/10.18203/2394-6040.ijcmph20233138

Keywords:

Rabies, Challenges, India

Abstract

Rabies is one of the fatal zoonotic diseases wreaking havoc on humanity since antiquity. India continues to suffer the greatest rabies burden of any country, both in terms of annual human deaths and disability-adjusted life years. While modern rabies management emphasizes the importance of achieving zoonotic disease control and prevention through a One Health approach, the disease remains challenging as its persistence is invariably multifaceted. Therefore, it is imperative to examine the enduring reasons for the increasing incidence of rabies in India. Between 2012- 2022, a systematic search of scientific publications, popular search engines like Google, as well as in the grey literature regarding rabies was carried out. Since rabies elimination boils down to addressing the reasons, it is first seen related to the large and unvaccinated stray dog population, where 97% of cases are by dog bites. A second finding is that many bite victims resorted to indigenous treatment practices due to insufficient awareness and knowledge about the disease. Incomplete treatment practices also led to some deaths, especially because rabies vaccines are not affordable or accessible to poverty-stricken populations. Rarely, vaccine failures were caused by a lack of vaccine potency, a wound type, or ineffective administration methods. Even with all these data incorporated, there was no information on prevalence/incidence estimates of dog bites in recent years through national data. Therefore, without intensified surveillance, sustained political commitment, enormous mobilization of resources, and rabies education, the epidemic waves of this fatal disease will continue in India. 

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References

Hankins DG, Rosekrans JA. Overview, prevention, and treatment of rabies. Mayo Clin Proc. 2004;79(5):671-6.

Rabies. Available from: https://www.who.int/news-room/fact-sheets/detail/rabies. Accessed on 20 February 2023.

Estimating the Global Burden of Endemic Canine Rabies Diseases. Available at: https://.plos.org/ plosntds?id=10.1371/.pntd.0003709. Accessed on 20 February 2023.

Rabies information for travellers Fact sheets. Available at: https://www.health.nsw.gov.au/Infectious/ fact sheets/Pages/rabies-travel.aspx. Accessed on 20 February 2023.

Rabies epidemiology and burden. Available at: https://www.who.int/activities/improving-data-on-rabies/rabies-epidemiology-and-burden. Accessed on 20 February 2023.

pp-rabies-summary-2018.pdf. Available at: https://cdn. who.int/media/docs/default-source/immunization/ position_documents/rabies/pp-rabies-summary-2018.pdf?sfvrsn=c9d92ce5_2. Accessed on 20 February 2023.

Rabies, India. Available at: https://www.who.int/ india/health-topics/rabies. Accessed on 20 February 2023.

Suraweera W, Morris SK, Kumar R, Warrell DA, Warrell MJ, Jha P. Deaths from Symptomatically Identifiable Furious Rabies in India: A Nationally Representative Mortality Survey. PLoS Negl Trop Dis. 2012;6(10):e1847.

National Rabies Control Programme.pdf. Available at: https://dghs.gov.in/WriteReadData/userfiles/file/National%20Rabies%20Control%20Programme.pdf. Accessed on 20 February 2023.

John D, Royal A, Bharti O. Epidemiological, humanistic and economic burden of dog-mediated rabies in India: a systematic review protocol. F1000 Res. 2021;10:32.

Why West Bengal, Karnataka account for half of the country’s rabies cases. Available at: https://www. financialexpress.com/health-3/why-west-bengal-karnataka-account-for-half-of-the-countrys-rabies-cases/1220440/. Accessed on 20 February 2023.

Rabies cases in Maharashtra doubled during first year of pandemic: RTI data. Available at: https://timesof india.indiatimes.com/city/pune/rabies-cases-in-maharashtra-doubled-during-first-year-of-pandemic-rti-data/articleshow/90529374.cms. Accessed on 20 February 2023.

Rabies deaths in Kerala despite vaccinations raises concerns. Available at: https://www.downtoearth.org. in/news/health/rabies-deaths-in-kerala-despite-vaccinations-raises-concerns-84895. Accessed on 20 February 2023.

Muringatheri M. Ignorance, negligence led to rabies deaths. Available at: https://www.thehindu.com/news/ national/kerala/ignorance-negligence-led-to-rabies-deaths/article65589421.ece. Accessed on 20 February 2023.

37 Cases, 37 Deaths: How The Menace of Rabies Has Gnawed at Tamil Nadu since Last Year. Available at: https://www.news18.com/news/india/37-cases-37-deaths-how-the-menace-of-rabies-has-gnawed-at-tamil-nadu-since-last-year-5756725.html. Accessed on 20 February 2023.

Health Programmes/Wellness. Available at: https:// www.nhp.gov.in/healthprogramme/national-action-plan-rabies-elimination. Accessed on 20 February 2023.

Pal P, Yawongsa A, Bhusal TN, Bashyal R, Rukkwamsuk T. Knowledge, attitude, and practice about rabies prevention and control: A community survey in Nepal. Vet World. 2021;14(4):933-42.

Jain P, Jain G. Study of General Awareness, Attitude, Behavior, and Practice Study on Dog Bites and its Management in the Context of Prevention of Rabies Among the Victims of Dog Bite Attending the OPD Services of CHC Muradnagar. J Fam Med Prim Care. 2014;3(4):355-8.

Kumar P, Domple V, Khakse G. Case report on fatal human rabies infection in central India. Int J Community Med Public Health. 2021;9(1):324-6.

Re: Rabies: beware of the dog. Available at: https://www.bmj.com/content/347/bmj.f5912/rr/667751. Accessed on 20 February 2023.

Population of India 2013-PopulationPyramid.net. Available at: https://www.populationpyramid.net/ india/2013/. Accessed on 20 February 2023.

Livestock Census. Available at: https://dahd.nic.in/ documents/statistics/livestock-census. Accessed on 20 February 2023.

King TB Ritchie. The Dog Economy Is Global & mdash; but What Is the World’s True Canine Capital?. Available at: https://www.theatlantic.com/business/ archive/2012/11/the-dog-economy-is-global-but-what-is-the-worlds-true-canine-capital/265155/. Accessed on 20 February 2023.

Haselbeck AH, Rietmann S, Tadesse BT, Kling K, Kaschubat-Dieudonné ME, Marks F, et al. Challenges to the Fight against Rabies-The Landscape of Policy and Prevention Strategies in Africa. Int J Environ Res Public Health. 2021;18(4):1736.

Fitzpatrick MC, Shah HA, Pandey A, Bilinski AM, Kakkar M, Clark AD, et al. One Health approach to cost-effective rabies control in India. Proc Natl Acad Sci USA. 2016;113(51):14574-81.

Abbas SS, Venkataramanan V, Pathak G, Kakkar M, on behalf of the Roadmap to Combat Zoonoses in India (RCZI) Initiative. Rabies control initiative in Tamil Nadu, India: A test case for the ‘One Health’ approach. Int Health. 2011;3(4):231-9.

Open Government Data Platform India. Available at: https://data.gov.in. Accessed on 20 February 2023.

Adopt One Health, Stop Rabies: India launches new national action plan for dog mediated rabies elimination by 2030. Available at: https://www.who. int/news/item/25-10-2021-adopt-one-health-stop-rabies-india-launches-new-national-action-plan-for-dog-mediated-rabies-elimination-by-2030. Accessed on 20 February 2023.

Changalucha J, Steenson R, Grieve E, Cleaveland S, Lembo T, Lushasi K, et al. The need to improve access to rabies post-exposure vaccines: Lessons from Tanzania. Vaccine. 2019;37(1):A45-53.

Hampson K, Ventura F, Steenson R, Mancy R, Trotter C, Cooper L, et al. The potential effect of improved provision of rabies post-exposure prophylaxis in Gavi-eligible countries: a modelling study. Lancet Infect Dis. 2019;19(1):102-11.

Rahman SA, Isloor S. Rabies on the Indian subcontinent. Rev Sci Tech Int Off Epizoot. 2018; 37(2):529-42.

WHO Expert Consultation on Rabies: second report. Available at: https://apps.who.int/iris/handle/10665/ 85346. Accessed on 20 February 2023.

Chomchay P, Khawplod P, Wilde H. Neutralizing antibodies to rabies following injection of rabies immune globulin into gluteal fat or deltoid muscle. J Travel Med. 2000;7(4):187-8.

Bharti OK, Sharma V. Failure of Postexposure Prophylaxis in a Patient Given Rabies Vaccine Intramuscularly in the Gluteus Muscle, Himachal Pradesh, India. Indian J Crit Care Med. 2018; 22(3):189-90.

Kerala: Two die after taking full course of anti-rabies vaccine; health authorities probing cause. Available at: https://www.indiatvnews.com/news/india/kerala-anti-rabies-vaccine-deaths-hospitals-health-authorities-rabies-dose-2022-08-22-801937. Accessed on 20 February 2023.

Rabies: Bite to head cause of death, antibodies detected; Abhirami cremated. Available at: https://www.onmanorama.com/news/kerala/2022/09/07/kerala-dog-bite-death-abhirami-niv-test-report-antibody-rabies-vaccination.html. Accessed on 20 February 2023.

Rabies vaccine fails, boy bitten by dog dies after 23 days. Available at: https://www.newindianexpress. com/states/kerala/2021/oct/08/rabies-vaccine-fails-boy-bitten-by-dog-dies-after-23-days-2368995.html. Accessed on 20 February 2023.

Deaths post jabs put rabies vaccine under cloud. Available at: https://www.newindianexpress.com/ states/kerala/2022/jul/02/deaths-post-jabs-put-rabies-vaccine-under-cloud-2471952.html. Accessed on 20 February 2023.

Dhane-Sarkar J. Study Says No Human Rabies in Goa for Four Years, Mission Claims Success The Wire Science. Available at: https://science.thewire.in/ health/goa-mission-eliminate-human-rabies/. Accessed on 20 February 2023.

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Published

2023-09-30

How to Cite

S. R., A. K., A. S., H., & S. Sundar, J. (2023). India’s sustaining challenges to combat rabies elimination: a comprehensive review. International Journal Of Community Medicine And Public Health, 10(10), 3952–3957. https://doi.org/10.18203/2394-6040.ijcmph20233138

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Review Articles