Association between serum uric acid level and microalbuminuria among type 2 diabetic patients: a cross-sectional study

Ahmed Mumtaz; Abdul Hadi Hasan; Ramsha Hassan; Muhammad Hassan; Tayyab Mumtaz Khan; Bismah Imtiaz Warrarich; Alizay Tauqeer; Syeda Ammara Fatima; Marryam Amer; Jehanzeb Akram

doi:10.18203/2394-6040.ijcmph20232666

Authors

Ahmed Mumtaz Rahbar Medical and Dental College, Lahore, Pakistan
Abdul Hadi Hasan Rahbar Medical and Dental College, Lahore, Pakistan
Ramsha Hassan Rahbar Medical and Dental College, Lahore, Pakistan
Muhammad Hassan Allama Iqbal Medical College, Lahore, Pakistan.
Tayyab Mumtaz Khan Allama Iqbal Medical College, Lahore, Pakistan
Bismah Imtiaz Warrarich Rahbar Medical and Dental College, Lahore, Pakistan
Alizay Tauqeer Rahbar Medical and Dental College, Lahore, Pakistan
Syeda Ammara Fatima Rahbar Medical and Dental College, Lahore, Pakistan
Marryam Amer Rahbar Medical and Dental College, Lahore, Pakistan
Jehanzeb Akram Rahbar Medical and Dental College, Lahore, Pakistan

DOI:

https://doi.org/10.18203/2394-6040.ijcmph20232666

Keywords:

Association, Serum, Uric acid, Microalbuminuria, Type 2, Diabetic, Patients, Cross-sectional

Abstract

Background: Diabetic nephropathy is common and its advancement is affected by different factors and one of them, serum uric acid has crucial role in the progression of kidney injury. The objective of this study is the determination of the association of serum uric acid level with the microalbuminuria among type 2 diabetic patients.

Methods: This cross-sectional study was performed in a tertiary care hospital of Rawalpindi, among 108 patients for 8 months from March 2021 to October 2021. Patients’ recruitment was done by the inclusion and exclusion criteria and convenient sampling technique. Data was obtained via a self-designed proforma. Descriptive and inferential statistics were applied for data analysis. P<0.05 was taken as statistically significant Data analysis was performed by SPSS version 25.0.

Results: From total study population, 60 (55.55%) were females, whereas, 48 (44.45%) were males. The means of age for the study population and serum uric acid were 48.98±15.67 years and 7.12±0.91 respectively. The overall frequencies of hyperuricemia and microalbuminuria were 41 (37.96%) and 33 (30.55%) respectively. The frequency of hyperuricemia was higher among older age group, women, and patients with microalbuminuria. The associations of serum uric acid level with the age group, gender, and albuminuria were significant statistically.

Conclusions: Correlation between the serum uric acid levels and albuminuria is statistically significant. Serum uric acid levels have statistically significant relationship with age and gender as well. Serum uric acid level was higher among older age group, females, and patients with microalbuminuria.

Metrics

Metrics Loading ...

References

Hou L, Shi Y, Wang S, Chen Q, Li Q, Zhao M, et al. Associations of serum uric acid level with diabetic retinopathy and albuminuria in patients with type 2 diabetes mellitus. J Int Med Res. 2020;48(12):0300060520963980.

Sadeeqa S, Fatima M, Latif S, Afzal H, Nazir SU, Saeed H. Prevelance of metformin-induced gastrointestinal problems. Acta Poloniae Pharmaceutica-Drug Res. 2019;76(6):1073-7.

Iftikhar R, Qadir A, Iqbal Z, Usman H. Prevalence of vitamin B12 deficiency in patients of type 2 diabetes mellitus on metformin: a case control study from Pakistan. Pan African Med J. 2014;16(1).

Bilal M, Haseeb A, Rehman A, Arshad MH, Aslam A, Godil S, et al. Knowledge, attitudes, and practices among nurses in Pakistan towards diabetic foot. Cureus. 2018;10(7).

Sana MA, Chaudhry M, Malik A, Iqbal N, Zakiuddin A, Abdullah M. Prevalence of microalbuminuria in type 2 diabetes mellitus. Cureus. 2020;12(12).

Viswanathan V, Tilak P, Kumpatla S. Risk factors associated with the development of overt nephropathy in type 2 diabetes patients: A 12 years observational study. Indian J Med Res. 2012;136(1):46.

Leung WK, Gao L, Siu PM, Lai CW. Diabetic nephropathy and endothelial dysfunction: Current and future therapies, and emerging of vascular imaging for preclinical renal-kinetic study. Life Sci. 2016;166:121-30.

Cai W, Duan XM, Liu Y, Yu J, Tang YL, Liu ZL, et al. Uric acid induces endothelial dysfunction by activating the HMGB1/RAGE signaling pathway. BioMed Res Int. 2017;2017.

Zoppini G, Targher G, Chonchol M, Ortalda V, Abaterusso C, Pichiri I, et al. Serum uric acid levels and incident chronic kidney disease in patients with type 2 diabetes and preserved kidney function. Diabetes care. 2012;35(1):99-104.

Jalal DI, Maahs DM, Hovind P, Nakagawa T. Uric acid as a mediator of diabetic nephropathy. InSeminars in Nephrol. 2011;31(5):459-65.

Qudwai W, Jawaid M. Frequency of uric acid levels symptomatic and asymptomatic hyperuricemia among the Pakistani population. Mid East J Fam Med. 2017;15:52-7.

Khan TM, Nawaz FK, Karim MS, Shafique Z, Anwar MS, Usman O. Incidence of microalbuminuria and factors affecting it in patients with type 2 diabetes mellitus. Cureus. 2022;14(7).

Warjukar P, Jain P, Kute P, Anjankar A, Ghangale SS. Study of microalbuminuria and uric acid in type 2 diabetes mellitus. Int J Cur Res Rev. 2020;2020.

Latif H, Iqbal A, Rathore R, Butt NF. Correlation between serum uric acid level and microalbuminuria in type-2 diabetic nephropathy. Pak J Med Sci. 2017;33(6):1371.