Sex selection drug and congenital malformations in North India
DOI:
https://doi.org/10.18203/2394-6040.ijcmph20233097Keywords:
Antenatal care, Child health, Congenital malformations, Reproductive health, Sex selectionAbstract
Background: An increasing incidence of congenital malformations (CMF) has been reported in North India in cases use of traditional drug by Mothers to have male child. Aim was to ascertain the association of Sex selection drug (SSD) and congenital malformations.
Methods: This hospital-based age-sex matched pair case control study was done at Advanced Pediatric Centre, Obstretics and Gynaecology department (ANC clinic, Maternity ward, labor room etc.) and Special Clinics, PGIMER, Chandigarh, India in 2019. The mothers were interviewed to collect information about risk factors.
Results: Two hundred three CMF (under five children and gestational CMF) cases and same number of controls were studied. Significant association of CMF was observed with the use of sex selection drugs by mothers (OR= 4.35).
Conclusions: The use of sex selection drugs is an avoidable risk factor of CMF and is of high public health importance. People need to be educated about this.
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References
Suresh S, Thanga VG, Sujatha J, Indrani S. Methodological issues in setting up a surveillance system for birth defects in India. Natl Med J India. 2005;18(5):259-62.
Dimes M. The Hidden Toll of Dying and Disabled Children, The March of Dimes Global Report on Birth Defects. 2008. Available at: www.marchofdimes.com/phnec/phnec.asp. Accessed on 7 June 2019.
Choudhery A, Talukdar G, Sharma A. Neonatal Congenital Malformation in Calcutta. Indian Pediatr. 1984;21:399-405.
Kumar V, Singh AJ, Marwaha RK. An epidemiological study of congenital malformations in rural children. Indian Pediatr. 1994;31:909-14.
Merchant SM. Indian Council of Medical Research Center. Mumbai, Annual Report. 1989:27.
Kulshreshtha R, Nath LM, Upadhyay P. Congenital malformations in live born infants in a rural community. Indian Pediatr. 1983;20(1):45-9.
Chaturvedi P, Banerjee KS. Spectrum of congenital malformations in newborns from rural Maharashtra. Indian J Pediatr. 1989;56:501-7.
Indicators and measures of quality of life. Available at: www.bigcities.govt.nz/natural. Accessed on 10 June 2019.
Patel ZM, Adhia RA. Birth defect surveillance study. Indian J Pediatr. 2005;72:489-91.
Congenital disorder. Available at: http://en.wikipedia.org/wiki/congenital_disorder. Accessed on 10 June 2019.
Altman DG, Royston P. What Do We Mean by Validating a Prognostic Model? Stat Med. 2000;19(4):453-73.
Ericson K. Birth Defects, Medical Encyclopedia. Available at: www.answers.com/library/medicalencyclopedia. Accessed on 16 June 2019.
Singh M, Jawadi MH, Arya LS, Fatima. Congenital malformations at birth among live born infants in Afghanistan: A prospective study. Indian J Pediatr. 1982;49:331-5.
Ananijevic-Pandey J, Jarebinski M, Kastratovic B, Vlajinac H, Radojkovic Z, Brankovic D. Case-control study of congenital malformations. Euro J Epidemiol. 1992;8:871-4.
Savitz DA, Schwingl PJ, Keels MA. Influence of paternal age, smoking, and alcohol consumption on congenital anomalies. Teratol. 1991;44(4):429-40.
Agarwal SS, Singh US, Singh PS, Singh SS, Das VI, Sharma A, et al. Prevalence & spectrum of congenital malformations in a prospective study at a teaching hospital. Ind J Med Res. 1991;94:413-9.
Chaturvedi P, Banerjee KS. An epidemiological study of congenital malformations in newborn. Indian J Pediatr. 1993;60:645-53.
Ronya R, Gupta D, Ghosh SK, Narang R, Jain KB. Spectrum of congenital surgical malformations in newborns. J I M A. 2002;100(9):565-6.
Henry PY, Varma KK. Relationship between threatened abortion and congenital malformations. J Ind Associat Pedia Surg. 1996;1(1):13.
Hansen D, Lou HC, Olsen J. Serious life events and congenital malformations: a national study with complete follow-up. Lancet. 2000;356(9233):875-80.
Brandt LP, Nielsen CV. Job stress and adverse outcome of pregnancy: a causal link or recall bias?. Am J Epidemiol. 1992;135(3):302-11.
Stephen JG. Fielding a current idea: exploring the public health impact of electromagnetic radiation, Public Health. 2008;122(2):113-24.
Grover N. Congenital malformations in Shimla. In J Pediat. 2000;67:249-51.
Roy Choudhury A, Mukherjee M, Sharma A, Talukdar G, Ghosh PK. Study of 1,26,266 consecutive births for major congenital defects. Ind J Pediatr. 1989;56:493-9.
Simpson JL, Phillips OP. Spermicides, hormonal contraception and congenital malformations. Advances in contraception. 1990;6(3):141-67.
Bandopadhyaya S, Singh AJ. Sex selection drugs in rural North India. IJCM. 2007;32:32-4.
Chuang CH, Doyle P, Wang JD, Chang PJ, Lai JN, Chen PC. Herbal medicines used during the first trimester and major congenital malformations: an analysis of data from a pregnancy cohort study. Drug safety. 2006;29:537-48.
