Compliance to post-exposure prophylaxis among patients attending anti-rabies vaccination clinic in a tertiary health care centre in central India: a cross sectional study
DOI:
https://doi.org/10.18203/2394-6040.ijcmph20232384Keywords:
Anti-rabies vaccine, Compliance, Post-exposure prophylaxis, Rabies, Rabies immunoglobulinAbstract
Background: Rabies is a fatal but vaccine-preventable disease. Prevention of rabies in exposed individuals is possible by providing them with the proper post-exposure prophylaxis. This study aims to assess the compliance to post-exposure prophylaxis in animal bite cases and factors associated with it.
Methods: A cross sectional study was conducted between September 2022 to November 2022 using a predesigned, pretested proforma to interview 300 patients attending anti-rabies vaccination clinic in a tertiary health care centre in central India.
Results: Majority of the patients 268 (89.3%) suffered category 3 animal bite and 32 (10.7%) patients suffered category 2 animal bite. 125 (41.7%) patients washed the wound with water, soap and applied antiseptic. 234 (78%) patients completed their last dose of anti-rabies vaccine (ARV) while compliance to Rabies Immunoglobulin (RIG) was seen in 167 (63.3%) patients of all cases requiring it. Out of all the patients who took Equine RIG, 7 (4.5%) showed hypersensitivity reactions. Significant association was found between compliance to ARV with type of animal and status of animal after 10 days; and compliance to RIG with gender, socio-economic status, type of animal and type of wound.
Conclusions: Compliance to ARV and RIG in our study was 78% and 63.3% respectively. Major reason for poor compliance to RIG was the price of immunoglobulin. Health education regarding significance of post-exposure prophylaxis is needed among the population.
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References
World Health Organization. Rabies Fact sheets, 2023. Available at: https://www.who.int/news-room/fact-sheets/detail/rabies#:~:text=Key%20facts%201%20Rabies%20is%20a%20vaccine-preventable%20viral,all%20rabies%20transmissions%20to%20humans.%20...%20More%20items. Accessed on 19 January 2023.
Centers for Disease Control and Prevention. Rabies, 2022. Available at https://www.cdc.gov/rabies/ index.html. Accessed on 08 December 2022.
World Health Organization. Rabies in India. Available at: https://www.who.int/india/health-topics/rabies. Accessed 12 September 2022.
Ministry of Health and Family Welfare 2021: National Action Plan for Dog Mediated Rabies Elimination from India by 2030. Available at: https://pib.gov.in/PressReleaseIframePage.aspx?PRID=1758964. Accessed 21 January 2023.
Gudegowda K, Shivalingamurthy R,Vengatesan S, Sobagiah R ,Krishnappa A. Compliance to post exposure rabies vaccination among patients attending anti - rabies clinic in a tertiary care hospital, Bengaluru. Nat J Comm Med. 2016;7(10):811-15.
Lilare R, Rathod N, Narlawar U. Compliance of post exposure rabies vaccination among patients attending anti-rabies OPD in the Government Medical College, Nagpur. Inter J Comm Med Public Heal. 2018;5(7):3045-8.
Sharma A, Bhuyar P, Bhawalkar J, Pawar S. Profile of management of animal bite cases among rural population in district Pune, Maharashtra. Ind J Pub Heal. 2007;51(1).
Karmakar A, Bhattacharya A. Epidemiology of animal bites with special reference to post-exposure prophylaxis of rabies in and around Malda, West Bengal: A hospital-based study. Int J Cur Res Rev. 2017;9(10):19-22.
Nishant N, Sankhe L Rajguru C. Anti Rabies Vaccination compliance: A longitudinal study amongst patients attending Anti Rabies Vaccination OPD in a tertiary care hospital. J Med Sci Clin Res. 2018;6(1):32671-6.
Gadapani B, Rahini S, Manapurath R. Noncompliance of the post exposure prophylactic vaccination following animal bites reporting to a rural primary health center. J Fam Medi Prim Care. 2019;8(10):3258-62.
Domple V, Doibale MK, Sonkar VK, Aswar N, Khadilkar H, Jain S. Treatment compliance of self-reported dog bite cases attending outpatient department of Tertiary Care Hospital, Maharashtra. Int J Medi Pub Hea. 2015;5(4):297-300.
Kawale S, Giri P, Pandve H. Clinico-social profile of animal bite cases attending tertiary care teaching hospital in Maharashtra, India. Ind J Pub Heal Res Develop. 2020;11(7):885-90.
Jena D, Tripathi R, Pradhan S, Mahapatra D. A study of treatment compliance of dog bite cases reporting to anti rabies clinic of M.K.C.G Medical College, Odisha, India. Int J Comm Med Pub Heal. 2017;4(10):3757-61.
Titoria R, Gupta G. Adherence to recommended antirabies vaccine schedule: a rabies clinic based study. Inter J Prevent Curat Comm Med. 2018;4(4):9-12.
Praveen G, Subhashini K, Metri S,Sundar M. Assessment of compliance to anti-rabies vaccination of post exposure prophylaxis among animal bite cases reporting to dedicated anti rabies clinic of a tertiary care hospital, Hassan, Karnataka. Int J Comm Medi. 2019;11(3):48-53.
Datta M. Epidemiology and trend of rabies post exposure prophylaxis at anti rabies clinic of a tertiary care hospital in India. Science Rise: Med Sci. 2021;6(45):20-4.
Shivasakthimani R, Chellaiyan D, Ravivarman G, Murali R. Compliance of anti-rabies vaccine among dog bite victims in an urban slum of Chennai: a cross sectional study. Int J Commu Med Pub Heal. 2018;5(4):1487-91.
Wadde SK, Edake S, Dixit J, Nagaonkar A. Non-compliance of post exposure prophylaxis amongst dog bite cases attending anti rabies clinic of a tertiary care hospital – a record based study. Nat J Commu Med. 2018;9(9):643-6.
Sahu D, Bhatia V, Singh A. Anti-rabies vaccine compliance and knowledge of community health worker regarding animal bite management in rural area of eastern India. Cureus. 2021;13(3).
Gaikwad L, Pawar S. Compliance to rabies immunoglobulin in post-exposure prophylaxis of category III animal bite cases attending anti rabies clinic of government tertiary care hospital, Solapur, Maharashtra, India. Int J Commu Med Pub Heal. 2016;3(11):3166-9.