Study neonate’s complications in COVID-19 infected pregnant women in early period of pandemic in Ardabil province, Iran
DOI:
https://doi.org/10.18203/2394-6040.ijcmph20231260Keywords:
Newborn, Pregnant woman, Clinical and laboratory symptoms, COVID-19Abstract
Background: Pregnant women and neonates are considered as high-risk groups of population. Due to higher risk of COVID-19 in pregnant women, the aim of this study was to determine neonates' complications in COVID-19 infected pregnant women in early period of pandemic in Ardabil province.
Methods: This prospective cross-sectional study was conducted on 21 infected pregnant women and their neonates from Feb to June 2020 in Alavi Hospital, Ardabil. Mother’s clinical and laboratory findings and their neonates were registered in a checklist. Neonates’ complications were assessed and infants 'growth and developmental disorders followed up at 28 days, 6 months, and 12 months. Collected data were analysed by statistical methods in SPSS version 24.
Results: In terms of clinical symptoms, the most prevalence symptoms were shortness of breath, fever, chills and dry cough. 15 infected mothers had a cesarean section and there was no maternal and neonatal mortality in this study. Of the 21 neonates, 13 were boys and 8 girls. Five neonates had respiratory distress and were admitted to the intensive care unit for 1 week. In these 5 neonates, arterial pH was low and neonatal CRP was high and the blood culture was negative for them. Also, all neonates were negative for COVID-19. None of the newborns had problems with feeding and poor reflexes and other symptoms. All newborns had negative PCR. 19 neonates were born over 2500 grams.
Conclusions: Results showed that suffering to COVID-19 had not relation with growth disorder in neonates and mother's clinical symptoms had not different with other symptoms. So we can use similar investigations to control of COVID-19 in all pregnant women. Also, COVID-19 infection in newborns was not associated with growth and developmental disorders in 1 year fallow up.
References
Abdollahpour S, Khadivzadeh T. Improving the quality of care in pregnancy and childbirth with coronavirus (COVID-19): a systematic review. The Journal of Maternal-Fetal Neonatal Medicine. 2022;35(8):1601-9.
Yu N, Li W, Kang Q, Xiong Z, Wang S, Lin X, et al. Clinical features and obstetric and neonatal outcomes of pregnant patients withCOVID-19 in Wuhan, China: a retrospective, single-centre, descriptive study. The Lancet Infectious Diseases. 2020;( 20):176-86.
Liu H, Wang LL, Zhao SJ, Kwak-Kim J, MorG, Liao AH. Why are pregnant women susceptible to viral infection: an immunological viewpoint? Journal of reproductive immunology. 2020;13(9):15-26.
Trevisanuto D, Cavallin F, Cavicchiolo ME, Borellini M, Calgaro S, Baraldi E. Coronavirus infection in neonates: a systematic review. Archives of Disease in Childhood-Fetal and Neonatal Edition. 2021;106(3):330-5.
Elwood C, Boucoiran I, VanSchalkwyk J, MoneyD, Yudin M, Poliquin V. SOGC CommitteeOpinion–COVID-19 in Pregnancy. Journal ofObstetrics and Gynaecology Canada. 2020;15(9):85-96.
Díaz CA, Maestro ML, Pumarega MTM, AntónBF, Alonso CP, editors. Primer caso de infecciónneonatal por SARS-CoV-2 en España. Anales dePediatría; 2020;2(4):40-49.
Qiao J. What are the risks of COVID-19infection in pregnant women? The Lancet. 2020;395(10226):760-62.
Rasmussen SA, Smulian JC, Lednicky JA, WenTS, Jamieson DJ.Coronavirus Disease 2019 (COVID-19) and Pregnancy: Whatobstetricians need to know. American Journal of Obstetrics and Gynecology. 2020;22(5):415-26.
Bellini C, Gente M. Neonatal Transportand COVID-19 outbreak. Air Medical Journal. 2020;3(6):120-36.
Luo Y, Yin K. Management of pregnant women infected with COVID-19. The Lancet Infectious Diseases. 2020;15(20):191-97.
Di Mascio D, Khalil A, Saccone G, Rizzo G, Buca D, Liberati M, et al. Outcome of Coronavirus spectrum infections (SARS, MERS, COVID-19) during pregnancy: a systematic review and meta-analysis. American Journal of Obstetrics Gynecology MFM. 2020:100(1):129-37.
Schwartz DA. 2020. An analysis of 38 pregnant women with COVID-19, their newborn infants, and maternal-fetal transmission of SARS-CoV-2: maternal coronavirus infections and pregnancy outcomes. Archives of Pathology Laboratory Medicine. 2020; 4(12):56-89.
Chen H, Guo J, Wang C, Luo F, Yu X, Zhang W, et al. Clinical characteristics and intrauterine vertical transmission potential of COVID-19 infection in ninepregnant women: a retrospective review of medical records. The Lancet. 2020;395(10226):809-15.
Liu D, Li L, Wu X, Zheng D, Wang J, Yang L, et al. Pregnancy and Perinatal Outcomes of Women with Coronavirus Disease (COVID-19) Pneumonia: A Preliminary Analysis. American Journal of Roentgenology. 2020;4(6):1-6.
Yu N, Li W, Kang Q, Xiong Z, Wang S, Lin X, et al. Clinical features and obstetric and neonatal outcomes of pregnant patients with COVID-19 in Wuhan, China: a retrospective, single-centre, descriptive study. The Lancet Infectious Diseases. 2020:15(6):206-12.
Salehzadeh F, Pourfarzi F, Ataei S. The Impact of Colchicine on the COVID-19 Patients; A Clinical Trial Study. Research square. 2020;2(6):19-28.
Kazemi Aski S, Sharami SH, Hosseinzadeh F, Hesni E, Dalil Heirati SF, Ghalandari M, et al. Risk factors, clinical symptoms, laboratory findings and imaging of pregnant women infected with COVID-19 in North of Iran. Arch Iran Med. 2020;23(12):856–63.
Gurol-Urganci I, Waite L, Webster K, Jardine J, Carroll F, Dunn G, et al. Obstetric interventions and pregnancy outcomes during the COVID-19 pandemic in England: A nationwide cohort study. PLoS medicine. 2022;19(1):e1003884.
Guan M, Johannesen E, Tang CY, Hsu AL, Barnes CL, Burnam M, et al. Intrauterine fetal demise in the third trimester of pregnancy associated with mild infection with the SARS-CoV-2 Delta variant without protection from vaccination. The Journal of infectious diseases. 2022;225(5):748-53.
