Re-emergence of human monkeypox 2022: its ecology and public health significance-short review article


  • Rahama Sanusi Karama Department of Public Health, School of Allied Health Sciences, Noida International University-Gautam Budh Nagar Delhi-NCR, India
  • Ajoke Akinola Department of Public Health, School of Allied Health Sciences, Noida International University-Gautam Budh Nagar Delhi-NCR, India
  • John Kama Department of Internal Medicine, Ivanofrankivsk National Medical University, Ivanofrankivsk, Ukraine



Human monkeypox, Re-emergence, Ecology, Public health


Monkeypox virus (MPXV) is one of Orthopoxvirus subfamily, it’s refers to a zoonotic disease caused by MPXV. Human monkeypox, on the other hand, has a much lower morbidity and fatality rate than smallpox. Reference to the current resurgence, monkeypox outbreaks have been reported over the past 5 decades, 10 countries in Africa was initially discovered to be affected by the outbreak and subsequently 4 countries apart from Africa. Additionally, re-emergence of monkeypox in African countries, especially Nigeria about forty 40 years of the initial outbreak, midst 2010-2019. Climate change, deforestation, lack of proper health and research advance infrastructure among the society and uncontrol intake of bush meat in the African countries could have been the reason for the recent re-emergence of monkeypox within the communities. Public health significance of monkeypox outbreak could be the factors related to the vulnerability of the population towards MPXV when smallpox vaccination was stopped. Due to the rapid global outreach of monkeypox endemic, it should be therefore considered as a very serious re-surging pathogen in the world. However, detail and proper observational research could bring more light on the influence of MPXV on overall human population, together with the advancement in qualitative and quantitative of outbreak data collection, research in the current situation is crucial and need an emergency treat in order to encourage the researchers to improve more findings on the monkeypox outbreak, which will subsequently enhances appropriate case management and public health response.



Guagliardo SA, Reynolds MG, Kabamba J, Nguete B, Shongo Lushima R, Wemakoy OE et al. Sounding the alarm: Defining thresholds to trigger a public health response to monkeypox. PLoS Neglected Trop Dis. 2018;12(12):e0007034.

Ogoina D, Izibewule JH, Ogunleye A, Ederiane E, Anebonam U, Neni A et al. The 2017 human monkeypox outbreak in Nigeria-report of outbreak experience and response in the Niger Delta University Teaching Hospital, Bayelsa State, Nigeria. PLoS One. 2019;14(4):e0214229.

Tumewu J, Wardiana M, Ervianty E, Anggraeni S, Widia Y, Amin M et al. An adult patient with suspected of monkeypox infection differential diagnosed to chickenpox. Infectious Dis Rep. 2020;12(S1):33-5.

Doshi RH, Guagliardo SA, Doty JB, Babeaux AD, Matheny A, Burgado J et al. Epidemiologic and ecologic investigations of monkeypox, Likouala Department, Republic of the Congo, 2017. Emerging Infect Dis. 2019;25(2):273.

Khodakevich L, Ježek Z, Messinger D. Monkeypox virus: ecology and public health significance. Bull World Heal Organiz. 1988;66(6):747.

Moore MJ, Rathish B, Zahra F. Mpox (monkeypox). Treasure Island (FL): StatPearls Publishing; 2022. Available at: Accessed on 10 January, 2023.

Sklenovska N, Van Ranst M. Emergence of monkeypox as the most important orthopoxvirus infection in humans. Frontiers Publ Heal. 2018;6:241.

Multi-country monkeypox outbreak in non-endemic countries. Available at: Accessed on 10 January, 2023.

Jenewari FO. Monkey Pox in Nigeria: Epidemiology and Prevention. In Proceedings of the Problems and Prospects for the Development of Modern Medicine, GomSMU, Kharkiv, Ukrainian. 2019;194-5.

Brown K, Leggat PA. Human monkeypox: Current state of knowledge and implications for the future. Trop Med Infect Dis. 2016;1-8.

Alakunle E, Moens U, Nchinda G, Okeke MI. Monkeypox Virus in Nigeria: Infection Biology, Epidemiology, and Evolution. Viruses. 2020;12(11):1257.

Ugorji CV, Nworuh Ibe SNO, Iwuoha G, Abanobi OC. Factors associated with the practice of monkey pox preventive behaviors among health workers in Yenagoa LGA, Bayelsa state, Nigeria. IOSR J. Nurs Health Sci. 2019;8:75-85.

Sklenovská N, Van Ranst M. Emergence of Monkeypox as the Most Important Orthopoxvirus Infection in Humans. Frontiers Publ Heal. 2018;6:241.

Jezek Z, Grab B, Szczeniowski MV, Paluku KM, Mutombo M. Human monkeypox: secondary attack rates. Bull World Health Organ. 1988;66(4):465-70.

Nolen LD, Osadebe L, Katomba J, Likofata J, Mukadi D, Monroe B et al. Introduction of monkeypox into a community and household: Risk factors and zoonotic reservoirs in the Democratic Republic of the Congo. Am J Trop Med Hyg. 2015;93(2):410-5.

Fuller T, Thomassen HA, Mulembakani PM, Johnston SC, Lloyd-Smith JO, Kisalu NK et al. Using remote sensing to map the risk of human monkeypox virus in the Congo Basin. Ecohealth. 2011;8(1):14-25.

Guagliardo SAJ, Doshi RH, Reynolds MG, Dzabatou-Babeaux A, Ndakala N, Moses C et al. Do mon- keypox exposures vary by ethnicity? Comparison of Aka and Bantu suspected monkeypox cases. Am J Trop Med Hyg. 2020;102(1):202-5.

Reynolds MG, Davidson WB, Curns AT, Conover CS, Huhn G, Davis JP et al. Spectrum of infection and risk factors for human monkeypox, United States, 2003. Emerg Infect Dis. 2007;13(9):1332-9.

Brown K, Leggat PA. Human monkeypox: Current state of knowledge and implications for the future. Trop. Med. Infect. Dis. 2016;1:8.

Nasir IA, Dangana A, Ojeamiren I, Emeribe AU. Reminiscing the recent incidence of monkeypox in Nigeria: Its ecologic-epidemiology and literature review. Port Harcourt Med J. 2018;11:1-9.

Fowotade A, Fasuyi TO, Bakare RA. Re-emergence of monkeypox in Nigeria: A cause for concern and public enlightenment. Afr J Clin Exp Microbiol. 2018;19:307.

Wilson ME, Hughes JM, McCollum AM, Damon IK. Human monkeypox. Clin Infect Dis. 2014;58:260-7.

Delaune D, Iseni F. Drugdevelopment against small pox: Present and future. Antimicrob. Agents Chemother. 2020;64:1-22.

Centers for Disease Control and Prevention. Update: multistate out- break of monkeypox-Illinois, Indiana, Kansas, Missouri, Ohio, and Wisconsin, 2003. MMWR Morb Mortal Wkly Rep. 2003;52:642-6.

Reed KD, Melski JW, Graham MB. The detection of monkeypox in humans in the Western Hemisphere. N Engl J Med. 2004;350:342-50.

Centers for Disease Control and Prevention. Monkeypox. Available at: poxvirus/monkeypox/index.html. Accessed on 10 January, 2023.

Erez N, Achdout H, Milrot E, Schwartz Y, Wiener-Well Y, Paran N et al. Diagnosis of imported monkey- pox, Israel, 2018. Emerg Infect Dis. 2019;25(5):980-3.

Public Health England. Monkeypox case confirmed in England 2019. Available at: Accessed on 10 January, 2023.

Public Health England. Monkeypox case confirmed in England 2019. Available from: Accessed on 10 January, 2023.

Monkeypox-United Kingdom of Great Britain and Northern Ireland (Nigeria). 2021. Available at: Accessed on 10 January, 2023.

Yong SEF, Ng OT, Ho ZJM, Mak TM, Marimuthu K, Vasoo S et al. Imported monkeypox, Singapore. Emerg Infect Dis. 2020;26(8):1826-30.

CDC Newsroom. CDC and Texas Confirm Monkeypox In U.S. Traveler. 2021. Available at: Accessed on 10 January, 2023.

Reynolds MG, Carroll DS, Karem KL. Factors affecting the likelihood of monkeypox’s emergence and spread in the post-smallpox era. Curr Opin Virol. 2012;2(3):335-43.

Fine PE, Jezek Z, Grab B, Dixon H. The transmission potential of monkeypox virus in human populations. Int J Epidemiol. 1988;17(3):643-50.

Rimoin AW, Mulembakani PM, Johnston SC, Lloyd Smith JO, Kisalu NK, Kinkela TL et al. Major increase in human monkeypox incidence 30 years after smallpox vaccination campaigns cease in the Democratic Republic of Congo. Proc Natl Acad Sci USA. 2010;107(37):16262-7.

Rimoin AW, Kisalu N, Kebela-Ilunga B, Mukaba T, Wright LL, Formenty P et al. Endemic human monkeypox, Democratic Republic of Congo, 2001-2004. Emerg Infect Dis. 2007;13:934-7.

Durski KN, McCollum AM, Nakazawa Y, Petersen BW, Reynolds MG, Briand S et al. Emergence of Monkeypox - West and Central Africa, 1970-2017. Morbidity Mortality Weekly Rep. 2018;67(10):306-10.

Karama RS, Simon NH, Chatterjee A, Aswasthi S, Akinola A, Acharya S et al. Effectiveness of video-based teaching program to assess the knowledge of young mothers in identifying developmental milestones in Delhi NCR, India. Int J Heal Sci. 2022;6(S1):12194-04.

Akinola A, Karama R, Rajput M. Awareness of natural breastfeeding milk among mothers and the importance of colostrum within the first hour of birth in India. Int J Community Med Publ Heal. 2022;9(7):2992-7.




How to Cite

Sanusi Karama, R., Akinola, A., & Kama, J. (2023). Re-emergence of human monkeypox 2022: its ecology and public health significance-short review article. International Journal Of Community Medicine And Public Health, 10(4), 1609–1615.



Review Articles