Efficacy and safety of carbamide peroxide tooth-whitening gels


  • Yasmin M. Asaad North Jeddah Specialist Dental Center, King Abdullah Medical Complex, Jeddah, Saudi Arabia
  • Sultan T. Alshammari General Dentist, Hail Dental Center, Hail, Saudi Arabia
  • Ahlam M. S. Faloudah Riyadh Specialized Dental Center, Ministry of Health, Riyadh, Saudi Arabia
  • Taghreed M. Alwabel Dental Department, Prince Sultan Military Medical City, Riyadh, Saudi Arabia
  • Maryam S. Alhazmi Riyadh Specialized Dental Center, Ministry of Health, Riyadh, Saudi Arabia
  • Nadiyah H. Almalki Riyadh Specialized Dental Center, Ministry of Health, Riyadh, Saudi Arabia
  • Hussam E. Almalki College of Dentistry, King Saud University, Riyadh, Saudi Arabia
  • Moayad W. Alturki College of Dentistry, Imam Abdulrahman Bin Faisal University, Dammam, Saudi Arabia
  • Faten A. Alnasser Eastern Riyadh Dental Center, Ministry of Health, Riyadh, Saudi Arabia
  • Abdulaziz K. Subayt College of Dentistry, King Saud University, Riyadh, Saudi Arabia




Tooth bleaching, Whitening, Aesthetic dentistry, Carbamide peroxide, Over the counter, At-home, In-office


Carbamide and hydrogen peroxide are the most frequently utilized compounds for various whitening techniques, that differ as per peroxide level, method of administration, and exposure period, when it comes to the active solutions accessible for important tooth whitening. The 10±1% carbamide peroxide dosage was the only level to date to acquire the American Dental Association's stamp of approval, ensuring its safety and effectiveness for at-home tooth whitening with customized trays. There has been a noticeable growth in the range of in-office tooth whitening compounds commercially available, which typically use elevated carbamide peroxide levels (30 to 37%) with or without an additional illumination. Even though tooth sensitivity appears to be the most frequent side effect of carbamide peroxide bleaching, discomfort goes away when the plan of care is finished. Sensitivity is typically linked to a background of sensitive teeth, greater administration rate, or use of greater carbamide peroxide levels. Additionally, studies have showed that using 10% carbamide peroxide at home to lighten teeth had comparable effectiveness to other methods (over the counter or in-office whitening). Patients generally prefer home vital bleaching with 10% carbamide peroxide to office procedures with 35% hydrogen peroxide. When comparing the safety utilizing 16% carbamide peroxide for nightguard vital bleaching to a placebo or 10% carbamide peroxide, patients receiving 16% reported higher gingival soreness than those administered a 10% carbamide peroxide or a placebo.


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How to Cite

M. Asaad, Y., T. Alshammari, S., M. S. Faloudah, A., M. Alwabel, T., S. Alhazmi, M., H. Almalki, N., E. Almalki, H., W. Alturki, M., A. Alnasser, F., & K. Subayt, A. (2023). Efficacy and safety of carbamide peroxide tooth-whitening gels. International Journal Of Community Medicine And Public Health, 10(2), 869–874. https://doi.org/10.18203/2394-6040.ijcmph20230019



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