Pulp stones and its relation with co-morbid diseases
Keywords:Pulp, Stone, Systemic, Disease
Pulp stones are nodular, calcified masses that can develop in the pulp of healthy, damaged or even developing teeth. In addition to a number of other factors and idiopathic factors, a number of theories have been put forward about the etiological factors behind the occurrence of pulp stones. These include age, genetic susceptibility, pulp degeneration, pulp circulatory disturbances, inductive interactions between pulp tissue and epithelium, and orthodontic tooth movements. Recently, pulp stones development has been linked to a number of systemic disorders, including diabetes, renal diseases, autoimmune diseases, and coronary artery disease. Osteopontin appears to contribute to plaque calcification and is a component of atheromatous plaques. Calcifications have also been noted in renal and carotid arteries with osteopontin, and numerous studies have shown a relationship between atheromatous plaques in arteries and the development of pulp stones. The development of pulp stones, kidney stones, joint calcification, and atheromatous plaques in arteries are thought to share the same mechanism of apatite formation. It has been hypothesized that the biological apatite that nanobacteria produce on their cell walls, which is comparable to kidney stones and calcified tissue, may be a common cause of both pulp stones and atheromatous plaques seen in coronary artery disease. As per the findings of several studies, pulp stones are more severe in coronary artery disease patients. The purpose of this research is to review the available information about pulp stones and its relation with co-morbid diseases.
Jannati R, Afshari M, Moosazadeh M, Allahgholipour SZ, Eidy M, Hajihoseini M. Prevalence of pulp stones: A systematic review and meta-analysis. J Evid-Based Med. 2019;12(2):133-9.
Goga R, Chandler NP, Oginni AO. Pulp stones: a review. Int Endodont J. 2008;41(6):457-68.
Patil S, Sinha N. Pulp Stone, Haemodialysis, End-stage Renal Disease, Carotid Atherosclerosis. J Clin Diagnost Res. 2013;7(6):1228-31.
Srivastava KC, Shrivastava D, Nagarajappa AK, et al. Assessing the Prevalence and Association of Pulp Stones with Cardiovascular Diseases and Diabetes Mellitus in the Saudi Arabian Population-A CBCT Based Study. Int J Env Res Public Health. 2020;17(24).
Araya P, Vega-Marcich M, Olivares Boksamy K, et al. Pulp calcifications in patients with diabetes mellitus. Revista Cubana de Estomatología. 2020;57.
Nachiappan N, Chandran A, Swathika B, Ganesan S, Mahaprasad A, Muddebihal F, Nayyar AS. Pulp Stones: Diagnostic Significance in Early Diagnosis and Radiographic Correlation with Ischemic Heart Diseases. Indian J Radiol Imaging. 2021;31(2):277-83.
Patil SR. Prevalence of and relationship between pulp and renal stones: A radiographic study. J Oral Biol Craniofac Res. 2015;5(3):189-92.
Tarim Ertas E, Inci M, Demirtas A, et al. A Radiographic Correlation between Renal and Pulp Stones. West Indian Med J. 2014;63(6):620-5.
Horsophonphong S, Kitkumthorn N, Sritanaudomchai H, Nakornchai S, Surarit R. High Glucose Affects Proliferation, Reactive Oxygen Species and Mineralization of Human Dental Pulp Cells. Braz Dent J. 2020;31(3):298-303.
Jawahar G, Rao GN, Vennila AA, Fathima SD, Lawanya MKK, Doss DM, et al. Clinicopathological Correlation of Pulp Stones and Its Association with Hypertension and Hyperlipidemia: An Hospital-based Prevalence Study. J Pharm Bioallied Sci. 2021;13(2):S1268-74.
Babu SJ, Swarnalatha C, Rao AP, Kumar BB, Tilak BP, Naidu RB, Nayyar AS. Pulp Stones as Risk Predictors for Coronary Artery Disease. Int J Prev Med. 2020;11:7.
Edds AC, Walden JE, Scheetz JP, Goldsmith LJ, Drisko CL, Eleazer PD. Pilot study of correlation of pulp stones with cardiovascular disease. J Endodont. 2005;31(7):504-6.
Almutlaq M, Mathew S, Al-Eidan R, Alkhraisi D, Adam H. Prevalence of pulp stones and its relation with cardiovascular diseases and diabetes mellitus using digital radiographs: a retrospective study. Ann Dent Specialty. 2019;7(4).
Nayak M, Kumar J, Prasad LK. A radiographic correlation between systemic disorders and pulp stones. Indian J Dent Res. 2010;21(3):369-73.
Almadhoon HW, Al-Kafarna M, Asla MM, Gbreel MI, Abd Allah MAE, Almotairy N. The Association of Dental Pulp Stones to Cardiovascular and Renal Diseases: A Systematic Review and Meta-Analysis. J Endodont. 2022;48(7):845-54.
Khojastepour L, Bronoosh P, Khosropanah S, Rahimi E. Can dental pulp calcification predict the risk of ischemic cardiovascular disease? J Dentistry (Tehran, Iran). 2013;10(5):456-60.
Alsweed A, Farah R, Ps S, Farah R. The Prevalence and Correlation of Carotid Artery Calcifications and Dental Pulp Stones in a Saudi Arabian Population. Diseases (Basel, Switzerland). 2019;7(3).