Risk factors and screening benefits in pregestational and early gestation diabetes


  • Amaal Abdo Dahab
  • Taghreed Mohamed Aljohani Tayiba Primary Healthcare Center, Ministry of Health, Medina, Saudi Arabia
  • Roaa Ali Heameed Department of Family Medicine, King Fahad General Hospital, Jeddah, Saudi Arabia
  • Faisal Abdullah Alshehri Department of Family Medicine, King Fahad General Hospital, Jeddah, Saudi Arabia
  • Maha Zaidan Alrasheedi Primary Health Care, Almanar Primary Healthcare Clinic, Riyadh, Saudi Arabia
  • Amna Ismaeel Alsaegh College of Medicine, Sechenov University, Moscow, Russia
  • Safa Metahr Yahya College of Medicine, Jazan University, Jazan, Saudi Arabia
  • Deema Faleh Alanazi Department of Cardiology, Prince Abdullah Bin Abdulaziz Bin Musa’ed Cardiac Centre (PAAMCC), Arar, Saudi Arabia
  • Abdullah Jama Alsomali College of Medicine, Prince Sattam Bin Abdulaziz University, Riyadh, Saudi Arabia
  • Amani Mohammed Al Zainaldeen General Physician, Jubail General Hospital, Saihat, Saudi Arabia
  • Zainab Adel Slais Department of Ophthalmology, Qatif Central Hospital, Saihat, Saudi Arabia




Gestational, Diabetes, Risk, Screening


Gestational diabetes is one of the most widespread complications of pregnancy posing a serious clinical and public health challenge. Globally, 16.5% of pregnancies are affected by the gestational diabetes, and this percentage is expected to rise as the obesity pandemic spreads. It has severe short-term and long-term negative health effects on both the mother and the child, which emphasizes the importance of identifying the risk factors for gestational diabetes and taking steps to prevent the illness. Gestational diabetes occurs when pregnant women who have never been diagnosed with diabetes experience chronic hyperglycaemia caused by impaired glucose tolerance. Obesity, physical inactivity, multiparity, family history of diabetes mellitus, certain ethnicities, birth of a previous macrocosmic child are all risk factors for gestational diabetes. Maternal cardiovascular disease, type 2 diabetes, macrosomia, and difficulties in delivery are all some of the complications of gestational diabetes. Additionally, there is a longer-term risk for the child to develop obesity, type 2 diabetes, and cardiovascular disease. Screening and diagnostic tests for gestational diabetes are essential to identify the women who are at risk for developing gestational diabetes and thereafter reduce or eliminate the risk of unfavourable outcomes for both mother and child associated with gestational diabetes. Oral glucose tolerance test is the widely accepted screening test conducted between 24-28 weeks of pregnancy for the diagnosis of gestational diabetes. The purpose of this research is to review the available information about risk factors and screening benefits in pregestational and early gestational diabetes.


Santos Martín MT, Gómez Santos E, Torres del Pino M, Muñoz-Cobo GT, Pérez Hernández A. Gestational and pregestational diabetes: Perinatal characteristics and neonatal morbidity. Anales de Pediatría (English Edition). 2022;96(2):158-60.

Hannah W, Bhavadharini B, Beks H. Global burden of early pregnancy gestational diabetes mellitus (eGDM): A systematic review. Acta diabetologica. 2022;59(3):403-27.

Wang H, Li N, Chivese T. IDF Diabetes Atlas: Estimation of Global and Regional Gestational Diabetes Mellitus Prevalence for 2021 by International Association of Diabetes in Pregnancy Study Group's Criteria. Diabetes Res Clin Pract. 2022;183:109050.

Hanson E, Ringmets I, Kirss A, Laan M, Rull K. Screening of Gestational Diabetes and Its Risk Factors: Pregnancy Outcome of Women with Gestational Diabetes Risk Factors According to Glycose Tolerance Test Results. J Clin Med. 2022;11(17).

Kouhkan A, Najafi L, Malek M. Gestational diabetes mellitus: Major risk factors and pregnancy-related outcomes: A cohort study. Int J Reproduct Biomed. 2021;19(9):827-36.

Szmuilowicz ED, Josefson JL, Metzger BE. Gestational Diabetes Mellitus. Endocrinol Metabol Clin N Am. 2019;48(3):479-93.

Amiri FN, Faramarzi M, Bakhtiari A, Omidvar S. Risk Factors for Gestational Diabetes Mellitus: A Case-Control Study. Am J Lifestyle Med. 2021;15(2):184-90.

Farahvar S, Walfisch A, Sheiner E. Gestational diabetes risk factors and long-term consequences for both mother and offspring: a literature review. Expert Rev Endocrinol Metabol. 2019;14(1):63-74.

Lin PC, Hung CH, Chan TF, Lin KC, Hsu YY, Ya-Ling T. The risk factors for gestational diabetes mellitus: A retrospective study. Midwifery. 2016;42:16-20.

Teh WT, Teede HJ, Paul E, Harrison CL, Wallace EM, Allan C. Risk factors for gestational diabetes mellitus: implications for the application of screening guidelines. Aust N Zealand J Obstetr Gynaecol. 2011;51(1):26-30.

Lee KW, Ching SM, Ramachandran V. Prevalence and risk factors of gestational diabetes mellitus in Asia: a systematic review and meta-analysis. BMC Pregnancy Childbirth. 2018;18(1):494.

Kampmann U, Madsen LR, Skajaa GO, Iversen DS, Moeller N, Ovesen P. Gestational diabetes: A clinical update. World J Diabet. 2015;6(8):1065-72.

Petrović O. How should we screen for gestational diabetes? Curr Opinion Obstetr Gynecol. 2014;26(2):54-60.

Hong WY, Biggio JR, Tita A, Harper LM. Impact of Early Screening for Gestational Diabetes on Perinatal Outcomes in High-Risk Women. Am J Perinatol. 2016;33(8):758-64.

McLaren RA, Ruymann KR, Ramos GA, Osmundson SS, Jauk V, Berghella V. Early screening for gestational diabetes mellitus: a meta-analysis of randomized controlled trials. Am J Obstetr Gynecol MFM. 2022;4(6):100737.

Hillier TA, Pedula KL, Ogasawara KK, Vesco KK, Oshiro C, Van Marter JL. Impact of earlier gestational diabetes screening for pregnant people with obesity on maternal and perinatal outcomes. J Perinatal Med. 2022;50(8):1036-44.

Benhalima K, Van Crombrugge P, Devlieger R. Screening for pregestational and gestational diabetes in pregnancy: a survey of obstetrical centers in the northern part of Belgium. Diabetol Metabol Syndr. 2013;5(1):66.

Hiéronimus S, Le Meaux JP. Relevance of gestational diabetes mellitus screening and comparison of selective with universal strategies. Diabet Metabol. 2010;36(6 Pt 2):575-86.

Huhn EA, Rossi SW, Hoesli I, Göbl CS. Controversies in Screening and Diagnostic Criteria for Gestational Diabetes in Early and Late Pregnancy. Frontiers Endocrinol. 2018;9:696.




How to Cite

Dahab, A. A., Aljohani, T. M., Heameed, R. A., Alshehri, F. A., Alrasheedi, M. Z., Alsaegh, A. I., Yahya, S. M., Alanazi, D. F., Alsomali, A. J., Zainaldeen, A. M. A., & Slais, Z. A. (2022). Risk factors and screening benefits in pregestational and early gestation diabetes. International Journal Of Community Medicine And Public Health, 10(1), 346–350. https://doi.org/10.18203/2394-6040.ijcmph20223275



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