Multi-center study to analyse outcome of integrated treatment approach in COVID-19 patients

Suraj Purushothaman; Prasant Kumar Dhotre; Kamlesh Prakash Vanarase; Gajanan Kisan Jadhao; Abhay Gyanchand Maurya; Sanjay Mohanlal Gupta; Vijaykumar Gawali

doi:10.18203/2394-6040.ijcmph20230228

Authors

Suraj Purushothaman Department of Critical Care, Bhaktivedanta Hospital and Research Institute, Mira Road, Maharashtra, India
Prasant Kumar Dhotre Department of Critical Care, Bhaktivedanta Hospital and Research Institute, Mira Road, Maharashtra, India
Kamlesh Prakash Vanarase Medical Officer, Bhaktivedanta Hospital and Research Institute, Mira Road, Maharashtra, India
Gajanan Kisan Jadhao Medical Officer, Bhaktivedanta Hospital and Research Institute, Mira Road, Maharashtra, India
Abhay Gyanchand Maurya Medical Officer, Bhaktivedanta Hospital and Research Institute, Mira Road, Maharashtra, India
Sanjay Mohanlal Gupta Medical Officer, Bhaktivedanta Hospital and Research Institute, Mira Road, Maharashtra, India
Vijaykumar Gawali Department of Medical Research and Education, Bhaktivedanta Hospital and Research Institute, Mira Road, Maharashtra, India

DOI:

https://doi.org/10.18203/2394-6040.ijcmph20230228

Keywords:

COVID-19, Limited resource setting, Minimal use of oxygen, Mortality, Patient outcome, Progesterone as immunomodulator, Treatment strategy

Abstract

Background: This study presents the outcome of integrated treatment approach based on government mandated standard allopathic treatment along with alternatives in COVID-19 patients. The aim of our study was to investigate the outcome of treatment strategy, co-morbid status, recovery and mortality rate of COVID-19 patients at Bhaktivedanta Hospital and Research Institute.

Methods: Post ethics committee approval for multiple centers, data for 1049 COVID-19 patients (RTPCR confirmed cases) of all age groups and genders which were admitted in a dedicated covid hospital from March 2020 to November 2020 was analysed retrospectively.

Results: This study highlights the management of COVID-19 patients with an integrated approach. In our cohort with 36.7%, 44.70 %, 18.58% of mild, moderate and severe cases respectively, mortality rate was only 3.43% of total positive patients admitted at our hospital.

Conclusions: We emphasize that even in healthcare facilities with limited resource and poor infrastructure and lack of ICU facilities, clinical observation-based management can help to reduce mortality considerably. Unique features of our study include use of progesterone as an immune modulator, use of dual antiviral agents and use of age-related lower limit of oxygen saturation.

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