Neurological complications of COVID-19 in children and its effect on the quality of life
Keywords:Neurological, Complication, Coronavirus, Disease
Coronavirus disease 2019, a pandemic that recently enveloped the world is a highly transmissible respiratory disease leading to 2,409,011 deaths in 2021. The most prevalent clinical symptoms in coronavirus disease 2019 patients are fever, cough, shortness of breath, and other respiratory issues. Coronavirus disease 2019 exhibits various neurological manifestations and complications which are quite rare in children. The purpose of this research is to review the available information about neurological complications of Coronavirus disease 2019 in children. Coronavirus disease 2019 is linked to neurological complications in children, including headaches, encephalopathy, and certain other neurological disorders. Involvement of the nervous system in coronavirus infection is either immediate, during the progression of the disease, after recovery, or as part of multisystem inflammatory syndrome in children. The clinical manifestations of coronavirus disease in new-borns and infants with neurological complications vary and can affect the whole neuraxis, affecting the central nervous system, peripheral nervous system, or both. In addition, children with multisystem inflammatory syndrome and coronavirus had severe neurological complications such as encephalitis, epilepsy, coma, dementia, dysgeusia or ageusia, aseptic meningitis, stroke, dysarthria, dysphagia, cerebellar ataxia, axial hypotonia, and drowsiness. Seizures in children are normally reported when they are suffering from fever due to viral infection. Neurological complications in children are rare and limited literature is available in this regard. More comprehensive, clinical follow-up studies can significantly contribute to understanding the relationship among coronavirus disease effects and neurological complications among children.
Rahman S, Montero MTV, Rowe K, Kirton R, Kunik F. Epidemiology, pathogenesis, clinical presentations, diagnosis and treatment of COVID-19: a review of current evidence. Expert Rev Clin Pharmacol. 2021;14(5):601-21.
Halaji M, Heiat M, Faraji N, Ranjbar R. Epidemiology of COVID-19: An updated review. J Res Med Sci. 2021;26:82.
Govil-Dalela T, Sivaswamy L. Neurological Effects of COVID-19 in Children. Pediatr Clin North Am. 2021;68(5):1081-91.
Zimmermann P, Pittet LF, Curtis N. How Common is Long COVID in Children and Adolescents? Pediatr Infect Disease J. 2021;40(12):e482-7.
Ellul MA, Benjamin L, Singh B. Neurological associations of COVID-19. Lancet Neurol. 2020;19(9):767-83.
Fan S, Xiao M, Han F. Neurological manifestations in critically ill patients with COVID-19: a retrospective study. Frontiers Neurol. 2020;806.
Molloy EJ, Bearer CF. COVID-19 in children and altered inflammatory responses. In. Vol 88: Nature Publishing Group. 2020;340-41.
Diorio C, Henrickson SE, Vella LA. Multisystem inflammatory syndrome in children and COVID-19 are distinct presentations of SARS–CoV-2. J Clin Investigation. 2020;130(11):5967-75.
Schober ME, Pavia AT, Bohnsack JF. Neurologic Manifestations of COVID-19 in Children: Emerging Pathophysiologic Insights. Pediatr Crit Care Med. 2021;22(7).
Siddique R, Khan S, Shabana. Neurological complications of COVID-19 in children and the associated immunological responses. J King Saud University Sci. 2022;34(3):101884.
Ahmad I, Rathore FA. Neurological manifestations and complications of COVID-19: A literature review. J Clin Neurosci. 2020;77:8-12.
Principi N, Esposito S. Are we sure that the neurological impact of COVID 19 in childhood has not been underestimated? Ital J Pediatr. 2021;47(1):191.
Panda PK, Sharawat IK, Panda P, Natarajan V, Bhakat R, Dawman L. Neurological Complications of SARS-CoV-2 Infection in Children: A Systematic Review and Meta-Analysis. J Trop Pediatr. 2020;67(3).
Stafstrom CE. Neurological effects of COVID-19 in infants and children. Develop Med Child Neurol. 2022;64(7):818-29.
LaRovere KL, Riggs BJ, Poussaint TY. Neurologic Involvement in Children and Adolescents Hospitalized in the United States for COVID-19 or Multisystem Inflammatory Syndrome. JAMA Neurol. 2021;78(5):536-47.
Ray STJ, Abdel-Mannan O, Sa M. Neurological manifestations of SARS-CoV-2 infection in hospitalised children and adolescents in the UK: a prospective national cohort study. Lancet Child Adolescent Heal. 2021;5(9):631-41.
Abdel-Mannan O, Eyre M, Löbel U. Neurologic and Radiographic Findings Associated With COVID-19 Infection in Children. JAMA Neurol. 2020;77(11):1440-45.
Boronat S. Neurologic Care of COVID-19 in Children. Frontiers in Neurol. 2021;11.
Lin JE, Asfour A, Sewell TB. Neurological issues in children with COVID-19. Neurosci Lett. 2021;743:135567.
Dilber B, Aydın ZGG, Yeşilbaş O. Neurological Manifestations of Pediatric Acute COVID Infections: A Single Center Experience. J Trop Pediatr. 2021;67(3).
Siracusa L, Cascio A, Giordano S. Neurological complications in pediatric patients with SARS-CoV-2 infection: a systematic review of the literature. Ital J Pediatr. 2021;47(1):123.
Aljomah L, Almedlej S, Baarmah D. Pediatrics COVID-19 and neurological manifestations: Single tertiary centre experience. e Neurological Sci. 2021;24:100355.