Helicobacter Pylori infection in rheumatic and autoimmune diseases


  • Khalid Mohammed Al Ghamdi Department of Gastroenterology, King Fahad General Hospital, Jeddah, Saudi Arabia
  • Khalid Mohammed Aljohani College of Medicine, University of Tabuk, Tabuk, Saudi Arabia
  • Saud Sayyaf Almuawi Department of Internal Medicine, King Fahad Hospital, Al Baha, Saudi Arabia
  • Mohanad Sulaiman Alharbi College of Medicine, Wroclaw Medical University, Wroclaw, Poland
  • Yazeed Hamdan Alwabisi College of Medicine, University of Tabuk, Tabuk, Saudi Arabia
  • Yazeed Ahmed Albalawi College of Medicine, University of Tabuk, Tabuk, Saudi Arabia
  • Sarah Sayed Alrazouqi College of Medicine, University of Jordan, Amman, Jordan
  • Sultan Khalil Almaghrabi College of Medicine, Marmara University, Istanbul, Turkey
  • Arwa Eid Alshahrani University Medical Center, King Khalid University, Abha, Saudi Arabia
  • Bushra Abdullah Almohi College of Medicine, King Khalid University, Abha, Saudi Arabia
  • Tamam Zamil Alshammari Department of Internal Medicine, Dr. Sulaiman Al Habib Hospital, Riyadh, Saudi Arabia
  • Rozana Louai Bawareth Department of Gastroenterology, King Fahad General Hospital, Jeddah, Saudi Arabia




H. pylori, Infection, Autoimmune, Diseases


Helicobacter pylori (H. pylori) infection is responsible for affecting almost 50% to 80% of people worldwide thus making it quite a prevalent bacterial infection. The relationship between infection and autoimmune disease have grown more obvious over the past 20 years. Although the exact cause of autoimmune diseases is unknown, it has long been hypothesized that genetically susceptible individuals may be more likely to develop autoimmune processes as a result of exposure to specific environmental agents, such as bacterial and viral infections or chemical exposures. One important factor in the development of autoimmune disorders is H. pylori infection. Clinically, H. pylori infection is frequently linked to peptic ulcer disease, while many infected people exhibit no symptoms. Atrophic gastritis, immunological thrombocytopenic purpura, and mucosa associated lymphoid tissue lymphoma are just a few of the illnesses that immune dysregulation has been linked to and reduced by H. pylori. Rheumatoid arthritis, systemic lupus erythematosus, and Sjogren's syndrome are examples of autoimmune diseases caused by an immune system that is malfunctioning in the body and invading healthy tissues. The purpose of this research is to review the available information about H. pylori infection in rheumatic and autoimmune disease. Numerous researchers have proposed that H. pylori may have a role in the emergence of autoimmune diseases due to its frequency and capability to alter human immune function. Although the results from majority of the present study findings in literature are contrasting. Further clinical research is needed to elaborately explain the association between autoimmune diseases and H. pylori infection.


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How to Cite

Al Ghamdi, K. M., Aljohani, K. M., Almuawi, S. S., Alharbi, M. S., Alwabisi, Y. H., Albalawi, Y. A., Alrazouqi, S. S., Almaghrabi, S. K., Alshahrani, A. E., Almohi, B. A., Alshammari, T. Z., & Bawareth, R. L. (2022). Helicobacter Pylori infection in rheumatic and autoimmune diseases. International Journal Of Community Medicine And Public Health, 9(11), 4283–4288. https://doi.org/10.18203/2394-6040.ijcmph20222655



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