Role of conjunctival ultraviolet autofluorescence device, as an indicator of ocular ultraviolet radiation exposure in pterygium and pinguecula among outdoor workers in Southern India

Authors

  • Ishwarya S. Kumar Vision Research Foundation, Sankara Nethralaya, Chennai, Tamil Nadu, India http://orcid.org/0000-0001-6470-6369
  • Jaganathan S. Sundar R.S. Mehta Jain Department of Biochemistry and Cell Biology, Vision Research Foundation, Sankara Nethralaya, Chennai, Tamil Nadu, India
  • Rashima Asokan Vision Research Foundation, Sankara Nethralaya, Chennai, Tamil Nadu, India
  • Sharada Ramasubramanyan R.S. Mehta Jain Department of Biochemistry and Cell Biology, Vision Research Foundation, Sankara Nethralaya, Chennai, Tamil Nadu, India

DOI:

https://doi.org/10.18203/2394-6040.ijcmph20222577

Keywords:

Pterygium, Conjunctival ultraviolet autofluorescence, Solar radiation, Lifetime ultraviolet exposure

Abstract

Background: Objective of the study was to evaluate conjunctival ultraviolet autofluorescence (CUVAF) device, as an indicator of ocular ultraviolet (UV) radiation exposure in pterygium and pinguecula among outdoor workers.

Methods: Subjects above 21 years of age engaged in outdoor work were enrolled based on inclusion criteria. A standardized questionnaire was administered to assess the lifetime UV exposure and erythemal UV dose were noted from the tropospheric emission monitoring internet service (TEMIS). Autofluorescence photographs of the nasal and temporal conjunctiva were taken using CUVAF tool and were assessed for presence of damage with exposure to UV radiation. Logistic regression was done to estimate the risk.

Results: A total of 229 participants, among them 205 (89.5%) were males and 24 (10.4%) were females. This included 75 (32.7%) with pterygium in one or both eyes, 69 (30.3%) with pinguecula and 85 (37.1%) normal. Median conjunctival damage in pterygium was 45.3 mm2 (IQR 35.1), in pinguecula was 17.9 mm2 (IQR 16.0) and in normal was 11.1 mm2 (IQR 25.2) demonstrating significant difference between the groups (p<0.001). The conjunctival damage was positively associated with pterygium OR: 1.12 (95% CI: 1.05-1.71, p<0.001) and pinguecula OR: 1.10 (95% CI: 1.07-1.49, p=0.01). Rural location, literacy status were the significant risk factors for development of pterygium with odds of 2.97 (95% CI: 1.46-6.05, p=0.003) and 4.84 (95% CI: 1.86-12.73, p=0.001) respectively.

Conclusions: Increasing conjunctival damage was found to be associated with prevalent pterygium.

 

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References

Lucas RM, McMichael AJ, Armstrong BK, Smith WT. Estimating the global disease burden due to ultraviolet radiation exposure. Int J Epidemiol. 2008;37:654-67.

Lucas RM, Norval M, Neale RE, Young AR, De Gruijl FR, Takizawa Y, Van der Leun JC. The consequences for human health of stratospheric ozone depletion in association with other environmental factors. Photochem Photobiol Sci. 2015;14:53-87.

Asokan R, Venkatasubbu RS, Velumuri L, Lingam V, George R. Prevalence and associated factors for pterygium and pinguecula in a South Indian population. Ophthalmic Physiol Opt. 2012;32:39-44.

Ivanov IV, Mappes T, Schaupp P, Lappe C, Wahl S. Ultraviolet radiation oxidative stress affects eye health. J Biophotonics. 2018;11:e201700377.

Lucas R. Global burden of disease from solar ultraviolet radiation. Environmental burden of disease series. 2006;13.

Arenas E, Armas G, Ramirez A. Pinguecula. Pan-Am J Ophthalmol. 2019;9.

Chui J, Di Girolamo N, Wakefield D, Coroneo MT. The pathogenesis of pterygium: current concepts and their therapeutic implications. Ocul Surf. 2008;6:24-43.

Rezvan F, Khabazkhoob M, Hooshmand E, Yekta A, Saatchi M, Hashemi H. Prevalence and risk factors of pterygium: a systematic review and meta-analysis. Surv Ophthalmol. 2018;63:719-35.

Marmamula S, Khanna RC, Rao GN. Population-based assessment of prevalence and risk factors for pterygium in the South Indian state of Andhra Pradesh: the Andhra Pradesh Eye Disease Study. Invest Ophthalmol Vis Sci. 2013;54:5359-66.

McCarty CA, Fu CL, Taylor HR. Epidemiology of pterygium in Victoria, Australia. Br J Ophthalmol. 2000;84:289-92.

Zhou WP, Zhu YF, Zhang B, Qiu WY, Yao YF.. The role of ultraviolet radiation in the pathogenesis of pterygia (Review). Mol Med Rep. 2016;14:3-15.

Chao SC, Hu DN, Yang PY, Lin CY, Nien CW, Yang SF, et al. Ultraviolet-A irradiation upregulated urokinase-type plasminogen activator in pterygium fibroblasts through ERK and JNK pathways. Invest Ophthalmol Vis Sci. 2013;54:999-1007.

McCarty CA, Lee SE, Livingston PM, Bissinella M, Taylor HR. Ocular exposure to UV-B in sunlight: the Melbourne visual impairment project model. Bull World Health Organ. 1996;74:353-60.

Taylor HR. The biological effects of UV-B on the eye. Photochem Photobiol. 1989;50:489-92.

Asawanonda P, Taylor CR. Wood’s light in dermatology. Int J Dermatol. 1999;38:801-7.

Kearney S, O'donoghue L, Pourshahidi LK, Richardson P, Laird E, Healy M, et al. Conjunctival ultraviolet autofluorescence area, but not intensity, is associated with myopia. Clin Exp Optom. 2019;102:43-50.

Ooi JL, Sharma NS, Papalkar D, Sharma S, Oakey M, Dawes P, et al. Ultraviolet fluorescence photography to detect early sun damage in the eyes of school-aged children. Am J Ophthalmol. 2006;141:294-8.

Wolffsohn JS, Drew T, Sulley A. Conjunctival UV autofluorescence--prevalence and risk factors. Cont Lens Anterior Eye. 2014;37:427-30.

Asokan R, Vijaya L, Kapur SG, George R. Estimation of lifetime ocular ultraviolet (UV) exposure levels in the rural and urban South Indian population using meteorological data from Tropospheric Emission Monitoring Internet Service. Int J Engineer Res Technol. 2016;5:374-7.

McKnight CM, Sherwin JC, Yazar S, Forward H, Tan AX, Hewitt AW, et al. Pterygium and conjunctival ultraviolet autofluorescence in young Australian adults: the Raine study. Clin Exp Ophthalmol. 2015;43:300-7.

Sherwin JC, Hewitt AW, Kearns LS, Griffiths LR, Mackey DA, Coroneo MT. The association between pterygium and conjunctival ultraviolet autofluorescence: the Norfolk Island Eye Study. Acta Ophthalmol. 2013;91:363-70.

Kearney S, O'Donoghue L, Pourshahidi LK, Richardson PM, Saunders KJ. The use of conjunctival ultraviolet autofluorescence (CUVAF) as a biomarker of time spent outdoors. Ophthalmic Physiol Opt. 2016;36:359-69.

Cajucom-Uy H, Tong L, Wong TY, Tay WT, Saw SM. The prevalence of and risk factors for pterygium in an urban Malay population: the Singapore Malay Eye Study (SiMES). Br J Ophthalmol. 2010;94:977-81.

Detorakis ET, Spandidos DA. Pathogenetic mechanisms and treatment options for ophthalmic pterygium: trends and perspectives (Review). Int J Mol Med. 2009;23:439-47.

Coroneo MT. Albedo concentration in the anterior eye: a phenomenon that locates some solar diseases. Ophthalmic Surg. 1990;21:60-6.

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Published

2022-09-28

How to Cite

Kumar, I. S., Sundar, J. S., Asokan, R., & Ramasubramanyan, S. (2022). Role of conjunctival ultraviolet autofluorescence device, as an indicator of ocular ultraviolet radiation exposure in pterygium and pinguecula among outdoor workers in Southern India. International Journal Of Community Medicine And Public Health, 9(10), 3816–3823. https://doi.org/10.18203/2394-6040.ijcmph20222577

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Original Research Articles