Published: 2021-05-25

Esophageal carcinoma with acro-metastasis: a rare case report

Mohammad Saad Ahmed, Hina Pathan, Sheeza Imtiaz, Jawaid Mallick, Shabbir Hussain, Saifullah Ubaidullah


The aim of this case report was to present a rare case of bony metastases originated from squamous cell carcinoma of the mid esophagus, thus, underline the need for early diagnosis and possible treatment of suspicious bony lesions among patients with esophageal malignancy. A 35-year-old man with esophageal carcinoma underwent esophagectomy whose pathology revealed stage III-C disease. During follow up, he was diagnosed to have bony hand metastasis. The patient died after some time. Therefore, follow-up of patients who are diagnosed with esophageal malignancy and underwent esophagectomy is mandatory in order to reveal early surgical stages as esophageal cancer is emerging as leading cause of cancer mortality worldwide. Complete resection of esophageal cancer and adjacent malignant lymph nodes is the only potentially curative treatment. Accurate preoperative staging and assessment of therapeutic response after neoadjuvant therapy are crucial in determining the most suitable therapy and avoiding inappropriate attempts at curative surgery.



Esophagectomy, Metastasis, Squamous cell carcinoma, Oncology

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Enzinger PC, Mayer RJ. Esophageal cancer. N Engl J Med. 2003;349(23):2241-52.

Blot WJ, Devesa SS, Fraumeni JF. Continuing climb in rates of esophageal adenocarcinoma: an update. JAMA. 1993;270(11):1320.

Onofrio V, Bovero E, Iaquinto G. Characterization of acid and alkaline reflux in patients with Barrett's esophagus. G.O.S.P.E. Operative Group for the study of Esophageal Precancer. Dis Esophagus. 1997;10(1):16-22.

Guanrei Y, Songliang Q. Endoscopic surveys in high-risk and low-risk populations for esophageal cancer in China with special reference to precursors of esophageal cancer. Endoscopy. 1987;19(3):91-5.

Tilanus HW. Changing patterns in the treatment of carcinoma of the esophagus. Scand J Gastroenterol. 1995;212:38-42.

Jankowski JA, Wright NA, Meltzer SJ, Triadafilopoulos G, Geboes K, Casson AG, et al. Molecular evolution of the metaplasia-dysplasia-adenocarcinoma sequence in the esophagus. Am J Pathol. 1999;154(4):965-73.

Koppert LB, Wijnhoven BP, Dekken H, Tilanus HW, Dinjens WN. The molecular biology of esophageal adenocarcinoma. J Surg Oncol. 2005;92(3):169-90.

Casson AG, Manolopoulos B, Troster M, Kerkvliet N, Malley F, Inculet R, et al. Clinical implications of p53 gene mutation in the progression of Barrett's epithelium to invasive esophageal cancer. Am J Surg. 1994;167(1):52-7.