Healing the chronic wounds in diabetes using old drugs

Authors

  • Khaled M. Hassan Department of Medicine, Consultant Family Medicine, Saudi Arabia
  • Abdullah A. Hamdi Department of Medicine, Prince Sattam Bin Abdulaziz University, Saudi Arabia
  • Suhail A. Alhamad Department of Medicine, Imam Muhammad Bin Saud Islamic University, Saudi Arabia
  • Reem Q. Alanzi Department of Medicine, Al-Farabi College of Medicine, Saudi Arabia
  • Yousef A. Aleid Department of Medicine, Al-Farabi College of Medicine, Saudi Arabia
  • Abdullah S. Aldarwish Department of Medicine, Al-Farabi College of Medicine, Saudi Arabia
  • Abdullah H. Almuntashiri Department of Medicine, King Khalid University, Saudi Arabia
  • Khalid Y. Almudawi Department of Medicine, King Khalid University, Saudi Arabia
  • Abdullah A. Alkhalifah Department of Medicine, Alqassim University, Saudi Arabia
  • Alaa F. Banjabi Department of Medicine, King Abdulaziz University, Saudi Arabia
  • Sarah H. Al-matar Department of Medicine, Dar Al-uloom University, Saudi Arabia
  • Turki S. Al-ayash Department of Medicine, Imam Abdulrahman Bin Faisal University, Saudi Arabia
  • Duaa J. Basrawi Department of Medicine, Batterjee Medical Colleage, Saudi Arabia
  • Mashael I. Aleidan Department of Medicine, Majmmah University, Saudi Arabia
  • Muataz I. Alnami Department of Medicine, Jazan University, Saudi Arabia
  • Mohammed A. Aljumaiah Department of Medicine, King Saud Bin Abdulaziz University for Health Sciences, Saudi Arabia

DOI:

https://doi.org/10.18203/2394-6040.ijcmph20203981

Keywords:

Chronic wounds, Wound closure, Diabetic foot ulcer, Dipeptidylpeptidase-4 inhibitor, Metformin, Phenytoin, Statins, Drug repurposing

Abstract

People with uncontrolled diabetes may develop poor circulation. As circulation slows down, blood moves more slowly, which makes it more difficult for the body to deliver nutrients to wounds. As a result, the injuries heal slowly, or may not heal at all. Due to the effects of diabetes on the nerves and blood vessels, diabetic patients might also experience other complications. These include heart disease, kidney disease, and eye problems. Hence, the need for therapeutic drugs is a must. In this review we analyze some drugs that have been used in diabetes wound healing including antiglycemic agents like dipeptidylpeptidase-4 (DPP4) inhibitors and metformin, statins and phenytoin. These drugs showed satisfying results giving the diabetes patients a glimmer of hop regarding their wound healing.

 

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Published

2020-09-25

How to Cite

Hassan, K. M., Hamdi, A. A., Alhamad, S. A., Alanzi, R. Q., Aleid, Y. A., Aldarwish, A. S., Almuntashiri, A. H., Almudawi, K. Y., Alkhalifah, A. A., Banjabi, A. F., Al-matar, S. H., Al-ayash, T. S., Basrawi, D. J., Aleidan, M. I., Alnami, M. I., & Aljumaiah, M. A. (2020). Healing the chronic wounds in diabetes using old drugs. International Journal Of Community Medicine And Public Health, 7(10), 4185–4188. https://doi.org/10.18203/2394-6040.ijcmph20203981

Issue

Vol. 7 No. 10 (2020): October 2020

Section

Review Articles