Clinical profile of ocular surface tumours at a tertiary care centre

Anju Kochar, Arif Khan, Nabab Ali Khan


Background: Corneal and conjunctival squamous lesions are uncommon but important because of their potential for causing ocular and even systemic morbidity and mortality. The ocular surface tumors can be congenital or acquired and show a broad spectrum ranging from non-neoplastic benign tumours and others demonstrate premalignant or malignant tumours such as Squamous cell carcinoma, Malignant Melanoma or Kaposi Sarcoma. The types and frequency of conjunctival tumours differ with demographic features such as age and race, systemic immune status, and chronic exposures, along with specific location within the conjunctiva. Objectives of this study was to study ocular surface neoplasm in terms of demographics, histopathological and clinical presentation.

Methods: This histopathological, prospective biopsy specimen series comprised of 107 patients of either sex and all age groups presenting with conjunctival lesion either benign or malignant. The study was carried out from December, 2017 to December, 2019 in the Department of Ophthalmology, S. P. Medical College and Associated Group of Hospitals, Bikaner in collaboration with Pathology Department. All enrolled cases of conjunctival lesion were screened by consecutive sampling after obtaining written consent.

Results: 39.25% patients had nevus followed by ocular surface squamous neoplasia (OSSN) (20.56 %). Various ocular surface neoplasia with respect to mean age, age group, occupation was statistically highly significant (p<0.05) whereas gender was statistically non-significant. On histopathological examination most common benign ocular surface neoplasia was nevus and most common malignant tumor was ocular squamous surface neoplasia (OSSN).

Conclusions: A large variety of conjunctival lesions may appear in the eye with variable presentation, most common benign ocular surface neoplasia was nevus and most common malignant tumor was ocular squamous surface neoplasia.



Nevus, Ocular surface tumor, OSSN

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Punja GM, Bharathi M, Shashidhar HB. A 10-year retrospective study of histopathological spectrum of conjunctival lesions in a tertiary care centre from south India. Indian J Path Oncol. 2019;6(3):365-7.

Yang J, Foster CS. Squamous cell carcinoma of the conjunctiva. Int Ophthalmol Clin. 1997;37:73-85.

Gupta S, Sinha R, Sharma N, Titiyal JS. Ocular surface squamous neoplasia. DJO. 2012;23:89-96.

Gichuhi S, Macharia E, Kabiru J, Zindamoyen AM, Rono H, Ollando E, et al. Clinical presentation of ocular surface squamous neoplasia in Kenya. JAMA Ophthalmol. 2015;133:1305-13.

Napora C, Cohen EJ, Genvert GI, Presson AC, Arentsen JJ, Eagle RC, et al. Factors associated with conjunctival intraepithelial neoplasia: a case control study. Ophthalmic Surg. 1990;21:27-30.

Shields CL, Chien JL, Surakiatchanukul T. Conjunctival tumors: review of clinical features, risks, biomarkers, and outcomes. Asia Pac J Ophthalmol. 2017;6(2):109-20.

Gichuhi S, Ohnuma S, Sagoo MS, Burton MJ. Pathophysiology of ocular surface squamous neoplasia. Exp Eye Res. 2014;129:172-82.

Honavar SG, Manjandavida FP. Tumours of the ocular surface: a review. Indian J Ophthalmol. 2015;63:187-203.

Shields JA, Shields CL, Potter P. Surgical management of conjunctival tumors. Arch Ophthalmol. 1997;115:808-15.

Tabin G, Levin S, Snibson G, Loughnan M, Taylor H. Late recurrences and the necessity for long-term follow-up in corneal and conjunctival intraepithelial neoplasia. Ophthalmol. 1997;104:485-92.

Nanji AA, Moon CS, Galor A, Sein J, Oellers P, Karp CL, et al. Surgical versus medical treatment of ocular surface squamous neoplasia: a comparison of recurrences and complications. Ophthalmol. 2014;121:994-1000.

Taylor HR. Ultraviolet radiation and the eye: an epidemiologic study. Trans Am Ophthalmol Soc. 1989;87:802-53.

Mondal SK, Nag DR, Bandyopadhyay R, Adhikari A, Mukhopadhyay S. Conjunctival biopsies and ophthalmic lesions: A histopathologic study in eastern India. J Res Med Sci. 2012;17(12):1176-9.

Elshazly LH. A clinicopathologic study of excised conjunctival lesions. Middle East Afr J Ophthalmol. 2011;18:48-54.

Vinutha BV, Niveditha H, Divya K, Kothari M. Clinical profile of conjunctival lesions: a prospective study. Int J Sci Stud. 2016;3(12):55-8.

Ceylan OM, Uysal Y. Clinical and histopathological analysis of conjunctival tumors. Gülhane Tıp Derg. 2010;52:248-51.

Navahi AR, Ashraf MJ, Seirfar N, Koohestani S, Abedi E. Conjunctival lesions; a histopathologic review in Fars Province, Iran. J Ophthalmic Vis Res. 2015;10:98-101.

Tahir R, Dhiman R, Vanathi M, Pushker N, Tandon R, Devi S. Clinicodemographic profile and treatment outcome in patients of ocular surface squamous neoplasia. Indian J Ophthalmol. 2017;65:936-41.