Published: 2019-12-25

Effect of treatment on the quality of life of cervical cancer patients: a prospective study from a tertiary care centre of West Bengal

Manisha Sarkar


Background: Cervical cancer is one of many health care ironies. Better survival rates demand better quality of life (QoL). The aim of present study was to determine the change in QoL of cervical cancer patients due to treatment.

Methods: An observational prospective study was conducted from July 2017 to June 2018 among 80 new cervical cancer patients without any prior history of treatment for cervical cancer, attending radiotherapy department of a tertiary care centre of West Bengal using a semi-structured schedule and European Organization for Research and Treatment of Cancer (EORTC) quality of life questionnaire (QLQ). Information was collected on socio-demographic and clinical aspects and QoL domains. Those with history of surgery for cervical cancer, advanced stage of disease were excluded. EORTC QLQ was administered at baseline and one month after completion of treatment. Data was analysed by percentage, means±standard deviation, range and Wilcoxon signed rank test etc. using SPSS-16.

Results: Only 60 patients could be analysed as 10 patients died and 10 lost to follow-up. After treatment there was a significant improvement in global health, physical, emotional and cognitive functioning as well as decrease in symptoms like fatigue, pain, insomnia, appetite loss and constipation along with worsening of financial difficulties. There was significant improvement in body image, decrease in problems of symptom experience, peripheral neuropathy and menopausal symptoms after treatment.

Conclusions: The cervical cancer patients show an overall improvement in their QoL in most of the domains after one month of treatment except worsening of financial difficulties. 


Cervical cancer, Quality of life, EORTC QLQ C-30, EORTC QLQ CX-24, EORTC

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IARC. Lyon: GLOBOCAN 2018. Population fact sheets; 2018. Available from: today/data/factsheets/populations/356-india-fact-sheets.pdf. Accessed on 02 November 2019.

Kumar S, Rana ML, Verma K, Singh N, Sharma AK, Maria AK, et al. PrediQt-Cx: Post treatment health related quality of life prediction model for cervical cancer patients. PLoS One. 2014;9(2):e89851.

Osoba D, Rodrigues G, Myles J, Zee B, Pater J. Interpreting the significance of changes in health-related quality of life scores. J Clin Oncol. 1998;16(1):139-44.

EORTC QLQ-C30. EORTC - the EORTC Groups Websites. Available from: eortc-qlq-c30. Accessed on 02 November 2019.

EORTC. Why do we need modules? EORTC - the EORTC Groups Websites. Available from: Accessed on 02 November 2019.

EORTC. Quality of life FAQ. Available from: Accessed on 02 November 2019.

Greimel ER, Kuljanic Vlasic K, Waldenstrom A-C, Duric VM, Jensen PT, Singer S, et al. The European Organization for Research and Treatment of Cancer (EORTC) Quality-of-Life questionnaire cervical cancer module. Cancer. 2006;107(8):1812–22. Available from: cncr.22217. Accessed on 02 November 2019.

Singh S. Causes for Miserable Quality Of Life of Northern Indian Female Cervical Cancer Patient Population. World J Pharmacy Pharm Sci. 2014;3(8):568–80.

Pradhan S, Sarkar S, Lakshminarayanan S. Quality of Life in Cervical Cancer Patients on Follow-Up Care in a Regional Cancer Centre in South India. 2015;4(1):139–50.

Satwe S, Salunkhe J, Satave V. Quality of Life (QOL) of Women with Radiation Therapy. IjsrNet. 2014;3(3):14–8. Available from: archive/v3i3/MDIwMTM5NjY=.pdf. Accessed on 02 November 2019.

Lachi PK, Malik M, Adavikolanu KR, Syedakram Kothwal S, Deepajoseph M, Syed FA, et al. Quality of life in patients of carcinoma cervix treated with chemoradiotherapy: A prospective study. 2013 ASCO Annual Meeting; J Clin Oncol. 2013;suppl:abstr-e16545. Available from: http:// Accessed on 02 November 2019.

Ljuca D, Marosevic G. Quality of life in patients with cervical cancer FIGO IIb stage after concomitant chemoradiotherapy. Radiol Oncol. 2009;43(4):293–8.

Fang P, Tan KS, Grover S, McFadien MK, Troxel AB, Lin L. Psychosocial encounters correlates with higher patient-reported functional quality of life in gynecological cancer patients receiving radio-therapy. Radiat Oncol. 2015;10(1):1–8.