Potent future antimalarials from Indian indigenous plants: a systematic review

Savitha Krishnaswamy


Malaria has a global impact due to development of resistance against the frontline anti-malarial drugs which include artemisinin and its derivatives. According to the ancient Indian system of medicine, the Ayurveda, several Indian indigenous plants have been used for treating various ailments. The use of Indian indigenous plants for treatment of malaria is proving to be quite effective and also offers as a cheaper alternative. The purpose of this review is to obtain knowledge about the different Indian indigenous plants that have antimalarial and antiplasmodial biological activities. Literature suggests that many indigenous Indian plants have shown good antiplasmodial and antimalarial activity with effects like decrease in anaemia, weight loss and pyrexia. Hence the Indian indigenous plants have a vast scope to be used as potent future antimalarials.


Malaria, Indian indigenous plants, Ayurveda, Reverse pharmacology

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Drug resistance in malaria. 2001. Available at: Accessed on 2 February 2018.

Savithramma N, Rao ML and Suhrulatha D. Screening of Medicinal Plants for Secondary Metabolites. Middle-East J Scienti Res. 2011;8(3):579-84.

Sen S, Chakraborty R. Revival, modernization and integration of Indian traditional herbal medicine in clinical practice: Importance, challenges and future. J Tradit Complement Med. 2017;7(2):234–44.

Shankar R, Deb S, Sharma BK. Antimalarial plants of northeast India: An overview. J Ayurveda Integr Med. 2012;3(1):10–16.

Kaushik NK, Bagavan A, Rahuman AA, Zahir AA, Kamaraj C, Elango G, et al. Evaluation of antiplasmodial activity of medicinal plants from North Indian Buchpora and South Indian Eastern Ghats. Malaria J. 2015. Available at: Accessed on 16 January 2018.

Godse CS, Tathed PS, Talwalkar SS, Vaidya RA, Amonkar AJ, Vaidya AB, et al. Antiparasitic and disease-modifying activity of Nyctanthes arbor-tristis Linn. in malaria: An exploratory clinical study. J Ayurveda Integr Med. 2016;7(4):238-48.

Kumar S, Yadav M, Yadav A, Rohilla P, Yadav JP. Antiplasmodial potential and quantification of aloin and aloe-emodin in Aloe vera collected from different climatic regions of India. BMC Complement Altern Med. 2017;17:369.

Bhat GP, Surolia N. In vitro antimalarial activity of extracts of three plants used in the traditional medicine of India. Am J Trop Med Hyg. 2001;65(4):304–8.

Patwardhan B, Mashelkar RA. Traditional medicine-inspired approaches to drug discovery: can Ayurveda show the way forward? Drug Discovery Today. 2009. Available at: http://www. Accessed 25 January 2018.