Effect of iron folic acid in combination with or without acsorbic acid on hematological and biochemical parameters in pregnant women
DOI:
https://doi.org/10.18203/2394-6040.ijcmph20162548Keywords:
Pregnant women, Iron folic acid, Ascorbic acid, SupplementationAbstract
Background: Iron deficiency anemia is major public health problem especially in pregnant women. Addition of Ascorbic acid may improve the effects of iron folic acid supplementation. The present study aimed at assessing the effect of supplementation of iron folic acid with and without ascorbic acid on hematological parameters of pregnant women.
Methods: This case-control study was conducted at Mahila Chikitsalaya, SMS Medical College Hospital, Jaipur. Two hundred pregnant women in the age group of 18-40 years were selected and divided into control (n=100) and experimental group (n=100) randomly. General profile of the subjects was elicited using a pre coded pre tested questionnaire. Women in control group were supplemented with Iron Folic Acid (IFA) and experimental group with IFA+Vitamin C 500mg (Ceilen tablet) for two months. Hematological and biochemical parameters were analyzed at baseline and after the supplementation period of two months.
Results: Average age of the subjects in control and experimental groups was 24.18±3.77 and 23.23±2.96 years respectively. Post intervention change in experimental Vs Control group was observed-Hb 18.04% Vs 5.49%, HCT 3.90% Vs 1.89%, MCV 1.97% Vs 0.88%, MCH 6.56% Vs 1.85%, RBC 5.39% Vs 3.68%, Trasnferrin Saturation 12.44% Vs 7.0%, Serum Iron 6.92% Vs 2.70% and TIBC -4.84% Vs 3.67% respectively.
Conclusions: Subjects in experimental group showed significantly higher change in hematological parameters compared to control group.References
Mahomed K. Iron and Folate Supplementation in pregnancy. Cochrane Database Syst. Rev. 2007;3 CD001135.
Quillan JP, Kwong A, Passmore P. An epidemiological investigation of pre-eclampsia and elevated blood pressure among Kampuchean refugee women at Sakaco Holding Center, Thailand. J Trop Med Hyg. 1983;86(5):185-91.
Spinillo A, Capuzzo E, Piazzi G, Nicola S, Colonna L and Iasci A. Maternal high-risk factors and serverity of growth deficit in small for gestational age infants. Early Hum. Dev. 1994;38:35-43.
Sapre S, Joshi V. 3 E's for safe motherhood. J Obstet Gyn Fam. Wel. 1996;2:7-11.
Cuervo LG, Mahomed K. Treatment for iron deficiency anaemia in pregnancy (Cochrane review). Issue 4 The Cochrane library. Chichester, UK: John Wiley and Sons, Ltd (Level 1). 2003;8(1):92.
World Health Organization/United Nations University/UNICEF. Iron deficiency anaemia, assessment, Prevention and Control: a guide for programme managers. Geneva: WHO, 2001.
Barrett FR, Whittaker PG, Williams JG. Absorption of non haem iron from food during pregnancy. BMJ. 1994;309:79.
FAO/WHO Requirements of vitamin A, iron, folate and vitamin B12. Report of a Joint FAO / WHO Expert Consultation. Rome: FAO (FAO Food and Nutrition Series No. 23). 1988.
Baynes RD, Skikine B. Iron absorption: In: Brock, JH, Halliday JW, Pipard MJ, Powell LW (eds). Iron metabolism in Health and Disease, London, UK: WB Saunders. 1994:151-87.
World Health Organization, Hook worm infection and Anaemia in girls and women. Report of WHO informal consultation Geneva. WHO,1994.
Schultink WJ, Angeles AI, Sastroamidjojo R, Gross R, Kayadi D. Weekly micronutrient supplementation to build iron stores in female Indonesian adolescents. Am J Clin Nutr. 1997;66(1):177-83.
Lynch SR. Ascorbic acid and iron nutrition, ASDCJ Dent Child. 1981;48:61-3.
Stookey LL. Ferrozine - a new spectrophotometric reagent for iron Anal chem. 1970;42:779-81.
Itano M. Serum Iron Survey. Am J Clin Pathol. 1978;70:516-22.
Artiss JD, Vinogradev S, Zak B. Spectrophotometric study of sensitive reagents for serum iron. Clin Biochem. 1981;14:311-5.
Tietz textbook of clinical chemistry and molecular diagnostic. 4th ed. Burtis CA, Aswood ER, Bruns DE. WB Saunders Co; 2005.
Mazza J. Manual of Clinical Hematology, Philadelphia: Lippincott Williams and Wilkins, 2002:129.
Varley's Practical Clinical Bio-Chemistry. 6th ed. Alan H, Gowenlock, CBS Publishers and Distributors Pvt. Ltd. 1988:927.
Cook JD, Finch CA. Assessing iron status of a population. Am J Clin Nutr. 1979;32:2115-9.
Puolakka, J, Janne O, Pakarinen A, Vihko R. Serum ferritin as a measure of stores during and after normal pregnancy with and without iron supplements. Acta Obstet Gynecol Scand supple. 1980;95:43-51.
International Nutritional Anaemia Consultative Group (INAC). Iron deficiency in women. Washington D.C. Nutrition Foundation. 1985;21-36.
Chard T, Lilford RJ. How useful is a test? J stud Ed. Progress in Obstetrics and Gynaecology. 1986;6:3-15.
Warren GT. Comparison of tests for diagnosis of iron depletion in pregnancy. American Journal of Obstetrics and Gynaecology. 1988;159 :1132-4.
Earl R, Woteki EM. Eds. Iron deficiency anaemia recommended guidelines for the prevention, detection and managements among US children and women of child bearing age. Washington DC. National Academy Press, 1993.
Gillespie S. Malnutrition in South East Asia. A regional profile, Rosa Publication no. 5, UNICEF. Regional office for South Asia Nov. 1997:92-3.
Mehnaz S. Afzal S. Khalil S, Khan Z. Impact of iron, folate and vitamin supplementation on the prevalence of Iron Deficiency Anemia in Non-pregnant females of periurban Areas of Aligarh. Indian Journal of community Medicine. 2006;31(3):201-3.
Sharma A, Prasad K, Rao VK. Identification of an appropriate strategy of control anaemia in adolescent girl of poor communities. Indian Pediatrics. 2000;37: 261-7.
Joseph B and Ramesh N. Weekly dose of iron-folate supplementation with vitamin c in the work place can prevent anemia in women employees. Pak J Med Sci. 2013;29(1):47-52.
Shu EN, Ogbodo SO. Role of ascorbic acid in the prevention of iron deficiency anaemia in pregnancy. Biochemical Research. 2005;16(1):40-4.
