A study on demographic and clinical profile of children with extra hepatic portal venous obstruction and with special reference to thrombophilic factors

Authors

  • Sushanta Kumar Jena Department of Hepatology, SCB Medical College, Cuttack, Odisha, India
  • Minakshi Mohanty Department of Community Medicine, SCB Medical College, Cuttack, Odisha, India
  • Umesh Chandra Patra Department of Hepatology, SCB Medical College, Cuttack, Odisha, India
  • Sanatan Behera Department of Hepatology, SCB Medical College, Cuttack, Odisha, India

DOI:

https://doi.org/10.18203/2394-6040.ijcmph20170468

Keywords:

Extrahepatic portal venous obstruction, Thrombophilia

Abstract

Background: Extra-hepatic portal vein obstruction (EHPVO) due to portal vein thrombosis is an important cause of portal hypertension in several region including India. The cause of thrombosis in these patients remains unclear. Objective of the study was to study the demographic features, etiology, clinical, laboratory findings with special reference to thrombophilic factors like protein C, protein S and antithrombin III deficiency in children with EHPVO.

Methods: The prospective analysis of 62 patients of EHPVO (<14 years of age) was done in the Department of Hepatology, SCB medical College, Cuttack. After detailed history, clinical examination, Ultrasound abdomen /color Doppler and Upper GI endoscopy, the subjects were analyzed for any deficiency of thrombophilic factors like protein C, protein S and antithrombin III.

Results: A total of 62 patients (37 Male, 25 Female) with mean age of 8.3+3.1 years were studied. Growth retardation was present in the form of wasting (alone) 20.9%, stunting (alone) 25.8% and both wasting and stunting was found in 9.8% cases. History of neonatal, umbilical sepsis and umbilical vein catheterization was found in 15.9% and 10.2% of cases respectively. Haemorrhage from oesophageal varices was prevalent symptoms in 85.9% patients. Splenomegaly was found in 91.9% patients and ascites in 9.4% patients. 47 patients studied for protein C, S and antithromibin III. 14 patients were found to have thrombophilia: protein C deficiency in 9, protein S deficiency in 8, Antithrombin III deficiency in 6.

Conclusions: The etiology of EHPVO in the majority of patients remain still unclear. It is commonly associated impaired somatic growth. The risk of EHPVO increases in the presence of thrombophilia, resulting from deficiency of naturally occurring anticoagulant proteins like Protein C, Protein S and Antithrombin III. 

Author Biography

Sushanta Kumar Jena, Department of Hepatology, SCB Medical College, Cuttack, Odisha, India

Department of Hepatology

Assistant Professor

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Published

2017-02-22

How to Cite

Jena, S. K., Mohanty, M., Patra, U. C., & Behera, S. (2017). A study on demographic and clinical profile of children with extra hepatic portal venous obstruction and with special reference to thrombophilic factors. International Journal Of Community Medicine And Public Health, 4(3), 640–645. https://doi.org/10.18203/2394-6040.ijcmph20170468

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Original Research Articles